Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID
Clovis Palmer,
Chrysostomos Perdios,
Mohamed Abdel-Mohsen
et al.
Abstract:Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are major manifestations of the post-acute sequelae of SARS-CoV-2 (PASC). Our understanding of lasting glucometabolic disruptions after acute COVID-19 remains unclear due to the lack of animal models for metabolic PASC. Here, we report a non-human primate model of metabolic PASC using SARS-CoV-2 infected African green monkeys (AGMs). Using this model, we have identified a dysregulated chemokine signature and hypersensitive T cell p… Show more
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