Immune disruptions and night shift work in hospital healthcare professionals: The intricate effects of social jet-lag and sleep debt

Faraut, Brice; Cordina‐Duverger, Emilie; Aristizabal, Guillen; Drogou, Catherine; Gauriau, Caroline; Sauvet, Fabien; Lévi, Francis; Léger, Damien; Guénel, Pascal

doi:10.3389/fimmu.2022.939829

Cited by 12 publications

(9 citation statements)

References 70 publications

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“…For instance, in breast cancer patients, aberrant circadian cortisol rhythm was found to be associated with both sleep disruption and suppressed activity of NK cells, ultimately concurring to poorer overall survival [136,156]. Modern wearable biosensors allow for unintrusive assessment of circadian and sleep cycles, whose alterations have also been associated with immune disruption in night workers [157,158]. Thus, digital solutions are allegedly going to be paramount in optimization of ICI ToD administration.…”

Section: Discussionmentioning

confidence: 99%

Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?

Karaboué,

Innominato,

Wreglesworth

et al. 2024

Br J Cancer

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Background Tolerability and antitumour efficacy of chemotherapy and radiation therapy can vary largely according to their time of administration along the 24-h time scale, due to the moderation of their molecular and cellular mechanisms by circadian rhythms. Recent clinical data have highlighted a striking role of dosing time for cancer immunotherapy, thus calling for a critical evaluation. Methods Here, we review the clinical data and we analyse the mechanisms through which circadian rhythms can influence outcomes on ICI therapies. We examine how circadian rhythm disorders can affect tumour immune microenvironment, as a main mechanism linking the circadian clock to the 24-h cycles in ICIs antitumour efficacy. Results Real-life data from 18 retrospective studies have revealed that early time-of-day (ToD) infusion of immune checkpoint inhibitors (ICIs) could enhance progression-free and/or overall survival up to fourfold compared to late ToD dosing. The studies involved a total of 3250 patients with metastatic melanoma, lung, kidney, bladder, oesophageal, stomach or liver cancer from 9 countries. Such large and consistent differences in ToD effects on outcomes could only result from a previously ignored robust chronobiological mechanism. The circadian timing system coordinates cellular, tissue and whole-body physiology along the 24-h timescale. Circadian rhythms are generated at the cellular level by a molecular clock system that involves 15 specific clock genes. The disruption of circadian rhythms can trigger or accelerate carcinogenesis, and contribute to cancer treatment failure, possibly through tumour immune evasion resulting from immunosuppressive tumour microenvironment. Conclusions and perspective Such emerging understanding of circadian rhythms regulation of antitumour immunity now calls for randomised clinical trials of ICIs timing to establish recommendations for personalised chrono-immunotherapies with current and forthcoming drugs.

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Section: Discussionmentioning

confidence: 99%

Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?

Karaboué,

Innominato,

Wreglesworth

et al. 2024

Br J Cancer

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“…The inflammatory factor could be assessed by biological analyses of e.g. cortisol in the saliva (8, 51). Because we have not gathered such measurements, we can only argue that both minor cognitive dysfunction and inflammation effects are extremely likely for our participants as a group.…”

Section: Discussionmentioning

confidence: 99%

“…Sleep deprivation is known to trigger an immune response leading to inflammation. A cortisol increment can be observed after a single night of sleep deprivation (8, 53, 54), so is plausible in our protocol that included two nights of mild sleep deprivation. In terms of mechanisms, sleep restriction and deprivation disturb the normal secretion of hormones like cortisol or testosterone, and is associated with increased rates of interleukin-6 and CRP as assessed on salivary samples in normal subjects.…”

Section: Discussionmentioning

confidence: 99%

“…In the last decade or so, insufficient sleep in adults with sleep debt has become an increasing prominent public health issue, with one third of the adult population sleeping less than six hours per night (1)(2)(3). This chronic sleep debt in adults is associated with an increased risk of chronic disease such as obesity, type 2 diabetes, cardiovascular diseases, inflammation, addictions, accidents and cancer (4)(5)(6)(7)(8). Short sleep duration and sleep debt also increase the risk of developing multiple comorbidities (9).…”

Section: Introductionmentioning

confidence: 99%

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Sleep deprivation detected by voice analysis

Thoret

Andrillon

Gauriau

et al. 2022

Preprint

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Using our voice represent an exquisitely intricate act, recruiting a host of cognitive and motor functions. As such, the voice is bound to reflect many aspects of the internal state of the speaker: personality, infections, stress, emotions. Here, we investigate whether sleep deprivation in otherwise normal and healthy persons can be detected through machine-learning analysis of vocal recordings. In contrast to previous approaches, we use fully generic acoustic features, derived from auditory-inspired models of sound processing, together with recently-developed machine learning interpretation techniques. Our results show that sleep deprivation can be accurately detected from generic acoustic features of vocal recordings. Two main different types of features were impacted by sleep deprivation: one related to speech rhythms, the other related to the timbre of the voice. We speculate that these features reflect two distinct physiological processes: the cognitive control of speech production and an inflammatory effect of the vocal apparatus. Crucially, the relative balance of these two effects varied widely for each individual, suggesting that the voice may be used as a "sleep stethoscope" to better understand the variety of idiosyncratic responses to sleep deprivation. Moreover, the method we outline is fully general and could be applied to the future investigation of any type of vocal biomarkers using machine-learning techniques.

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“…Evidence suggests that circadian disruption is involved in MAFLD ( Mukherji et al, 2020 ; Saran et al, 2020 ). The two most common causes of circadian disruption in today’s 7/24 society are jet lag and shift work, and jet lag is considered analogous to shift work ( Walker et al, 2020 ; Faraut et al, 2022 ), but few controlled studies have addressed the effects of chronic jet lag (CJ) on MAFLD, and its mechanisms remain incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

Chronic jet lag alters gut microbiome and mycobiome and promotes the progression of MAFLD in HFHFD-fed mice

Zheng,

Xiang,

Shi

et al. 2023

Front. Microbiol.

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Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide. Circadian disruptors, such as chronic jet lag (CJ), may be new risk factors for MAFLD development. However, the roles of CJ on MAFLD are insufficiently understood, with mechanisms remaining elusive. Studies suggest a link between gut microbiome dysbiosis and MAFLD, but most of the studies are mainly focused on gut bacteria, ignoring other components of gut microbes, such as gut fungi (mycobiome), and few studies have addressed the rhythm of the gut fungi. This study explored the effects of CJ on MAFLD and its related microbiotic and mycobiotic mechanisms in mice fed a high fat and high fructose diet (HFHFD). Forty-eight C57BL6J male mice were divided into four groups: mice on a normal diet exposed to a normal circadian cycle (ND-NC), mice on a normal diet subjected to CJ (ND-CJ), mice on a HFHFD exposed to a normal circadian cycle (HFHFD-NC), and mice on a HFHFD subjected to CJ (HFHFD-CJ). After 16 weeks, the composition and rhythm of microbiota and mycobiome in colon contents were compared among groups. The results showed that CJ exacerbated hepatic steatohepatitis in the HFHFD-fed mice. Compared with HFHFD-NC mice, HFHFD-CJ mice had increases in Aspergillus, Blumeria and lower abundances of Akkermansia, Lactococcus, Prevotella, Clostridium, Bifidobacterium, Wickerhamomyces, and Saccharomycopsis genera. The fungi-bacterial interaction network became more complex after HFHFD and/or CJ interventions. The study revealed that CJ altered the composition and structure of the gut bacteria and fungi, disrupted the rhythmic oscillation of the gut microbiota and mycobiome, affected interactions among the gut microbiome, and promoted the progression of MAFLD in HFHFD mice.

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Immune disruptions and night shift work in hospital healthcare professionals: The intricate effects of social jet-lag and sleep debt

Cited by 12 publications

References 70 publications

Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?

Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?

Sleep deprivation detected by voice analysis

Chronic jet lag alters gut microbiome and mycobiome and promotes the progression of MAFLD in HFHFD-fed mice

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