Immune, endocrine, and behavioral precursors to breast cancer recurrence: a case-control analysis

Thornton, Lisa M.; Andersen, Barbara L.; Carson, William E.

doi:10.1007/s00262-008-0485-6

Cited by 52 publications

(58 citation statements)

References 30 publications

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“…Several lines of evidence support the hypothesis that psychological stress can be a co-factor for the initiation and metastasis of cancer [27,33,39]. Clinical studies also show that stress, depression, and other psychological factors may influence cancer onset and progression [34,40]. Responses to various stress stimulations primarily cause the activation of autonomic nervous system and hypothalamic-pituitaryadrenal axis, resulting in catecholamine secretion from sympathetic neurons and the adrenal medulla [41].…”

Section: Discussionmentioning

confidence: 94%

The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells

Shi¹,

Liú

Duan

et al. 2010

Breast Cancer Res Treat

114

115

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In this study, β2-AR level was found to be up-regulated in MCF-7 cells overexpressing Her2 (MCF-7/Her2). Correlation of β2-AR level with Her2 status was demonstrated in breast cancer tissue samples. Constitutive phosphorylation of ERK, mRNA expression up-regulation of catecholamine-synthesis enzymes, and increased epinephrine release were detected in MCF-7/Her2 cells. β2-AR expression induced by epinephrine and involvement of ERK signaling were validated. The data indicate that Her2 overexpression and excessive phosphorylation of ERK cause epinephrine autocrine release from breast cancer cells, resulting in up-regulation of β2-AR expression. The data also showed that catecholamine prominently stimulated Her2 mRNA expression and promoter activity. The activation and nuclear translocation of STAT3 triggered by isoproterenol were observed. Enhanced binding activities of STAT3 to the Her2 promoter after isoproterenol stimulation were verified. Using STAT3 shRNA and dominant negative STAT3 mutant, the role of STAT3 in isoproterenol-induced Her2 expression was further confirmed. The data support a model where β2-AR and Her2 comprise a positive feedback loop in human breast cancer cells.

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Section: Discussionmentioning

confidence: 94%

The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells

Shi¹,

Liú

Duan

et al. 2010

Breast Cancer Res Treat

114

115

View full text Add to dashboard Cite

show abstract

“…Choi [53] reported a reduction in CD4 T cells during cancer treatment which made patients' recovery difficult. Furthermore, these treatmentrelated effects on the immune system reduced the ability of the body to fight against tumor cells, as well as viruses, by depleting NK cells which play an important role in the body's initial immune response [54]. Therefore, suppressing inflammation and/or improving immune function is a main objective of cancer treatment [28,55].…”

Section: Discussionmentioning

confidence: 99%

Effect of a 12-week walking exercise program on body composition and immune cell count in patients with breast cancer who are undergoing chemotherapy

Kim

Shin

Suk

2015

J. Exerc. Nutr, Biochem.

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Effect of a 12-week walking exercise program on body composition and immune cell count in patients with breast cancer who are undergoing chemotherapy. JENB., Vol. 19, No. 3, pp.255-262, 2015 [Purpose] The purpose of this study was to examine the effect of a 12-week walking exercise program on body composition and immune cell count in patients with breast cancer who are undergoing chemotherapy.[Methods] Twenty patients (age, 47.8 ± 3.12) participated in the study. Body composition (weight, body mass index, muscle weight, body fat mass, and percent body fat) and the cell counts for immune cells (white blood corpuscles, lymphocytes, helper T cells, cytotoxic T cells, natural killer cells, and natural killer T cells) were measured before and after the 12-week walking exercise program. SPSS 17.0 statistical software was used. The two-way repeated ANOVA with post hoc was used to determine the difference between time and interaction.[Results] There were significant reductions in the weight (p < .05), BMI (p < .01), and percent body fat (p < .05) after the 12-week walking exercise program. However, the immune cell counts did not change significantly.[Conclusion] These results indicated that the 12-week walking exercise program had an effect on the balances among weight, BMI and percent body fat in patients with breast cancer.

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“…[18][19][20] Such aberrations of cortisol rhythms are attributable to both the physical stress of having cancer 21 and psychological stress. 22,23 Flattened diurnal salivary cortisol rhythms predict early recurrence 14 and mortality from metastatic breast cancer. 24 Various psychotherapeutic interventions such as cognitive behavioral therapy, social support, and stress management have shown beneficial effects in reducing psychological distress [25][26][27] and HPA axis dysregulation associated with cancer.…”

mentioning

confidence: 99%

“…13,14 Cortisol, a stress hormone and an end-product of the HPA axis, has been reported to be elevated in breast cancer patients both prior to and following treatment. [15][16][17] Both elevated levels of cortisol and flattened high levels or erratic diurnal fluctuations of cortisol have been shown to cause down-regulation P sychological distress and morbidity are common sequelae to diagnosis and treatment in early breast cancer patients, [1][2][3] given that the majority of patients report symptoms of depression, anxiety, social dysfunction, and inability to work.…”

mentioning

confidence: 99%

Effects of a Yoga Program on Cortisol Rhythm and Mood States in Early Breast Cancer Patients Undergoing Adjuvant Radiotherapy: A Randomized Controlled Trial

Vadiraja¹,

et al. 2009

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Objectives. This study compares the effects of an integrated yoga program with brief supportive therapy in breast cancer outpatients undergoing adjuvant radiotherapy at a cancer center. Methods. Eighty-eight stage II and III breast cancer outpatients are randomly assigned to receive yoga (n = 44) or brief supportive therapy (n = 44) prior to radiotherapy treatment. Assessments include diurnal salivary cortisol levels 3 days before and after radiotherapy and self-ratings of anxiety, depression, and stress collected before and after 6 weeks of radiotherapy. Results. Analysis of covariance reveals significant decreases in anxiety ( P < .001), depression ( P = .002), perceived stress ( P < .001), 6 a.m. salivary cortisol ( P = .009), and pooled mean cortisol ( P = .03) in the yoga group compared with controls. There is a significant positive correlation between morning salivary cortisol level and anxiety and depression. Conclusion. Yoga might have a role in managing self-reported psychological distress and modulating circadian patterns of stress hormones in early breast cancer patients undergoing adjuvant radiotherapy.

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Immune, endocrine, and behavioral precursors to breast cancer recurrence: a case-control analysis

Abstract: Patients who would recur showed reliable biobehavioral alterations more than a year prior to their diagnosis. This novel observation may contribute to our understanding of the disease relapse processes.

Cited by 52 publications

References 30 publications

The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells

The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells

Effect of a 12-week walking exercise program on body composition and immune cell count in patients with breast cancer who are undergoing chemotherapy

Effects of a Yoga Program on Cortisol Rhythm and Mood States in Early Breast Cancer Patients Undergoing Adjuvant Radiotherapy: A Randomized Controlled Trial

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