Immune-enhancing activity comparison of sulfated ophiopogonpolysaccharide and sulfated jujube polysaccharide

Zhang, Jing; Chen, Jin; Wang, Deyun; Hu, Yuanliang; Zhang, Cunshuai; Qin, Tao; Liu, Cui; Sheng, Xin; Nguyen, The Luong

doi:10.1016/j.ijbiomac.2012.09.025

Cited by 34 publications

(13 citation statements)

References 27 publications

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“…Two fractions of ZSP (ZSP3c and ZSP4b) were believed to be responsible for immunological activity. Zhang et al (2013) purified four polysaccharides through protein removal and column chromatography, followed by addition of chlorosulfonic acid and pyridine under an optimal condition to obtain four sulfated polysaccharides sOPS 80 , sOPS t , sJPS 50 , and sJPS t , for comparison of immuneenhancing activity, with four unmodified polysaccharides as control. The in vivo finding showed that the sulfated polysaccharides could stimulate lymphocyte proliferation more effectively than their corresponding unmodified polysaccharides, with sOPS 80 possessing the highest efficiency.…”

Section: Immunomodulationmentioning

confidence: 99%

Functional components in Zizyphus with emphasis on polysaccharides

Kao

Chen

2014

Polysaccharides

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Zizyphus jujuba (Chinese jujube), mainly distributed in the subtropical regions of Asia, has been cultivated for over 4,000 years and used as food, food additive, flavor, as well as traditional Chinese herb, as it possesses analeptic, palliative, and antibechic functions. The fruit of jujube is quite popular due to high nutritional value and presence of many functional components, in which polysaccharide is the most important one. Polysaccharides, being essential constituents of all living organisms, are naturally occurring polymers of aldoses and ketoses linked together through glycosidic linkages. In recent years, polysaccharides of plant origin have emerged as a vital class of bioactive nature products; however, there is a lack of information regarding analysis and biological activity of jujube polysaccharides. Moreover, the composition of polysaccharides in jujube may vary with different species, growth environment, cultivar variety, and extraction and separation methods, which in turn may affect the overall biological activity. The objective of this manuscript is to review the current status associated with jujube polysaccharide, including nutritional and functional components; methods of extraction, purification, separation, identification, and quantitation; as well as biological activity.

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Section: Immunomodulationmentioning

confidence: 99%

Functional components in Zizyphus with emphasis on polysaccharides

Kao

Chen

2014

Polysaccharides

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“…In the case of impaired immunity, the individual suffers from increased susceptibility to a variety of illnesses (Dietert and Zelikoff, 2010;Morris et al, 2013). As the same with some chronic diseases, prevention is much more effective than treatment in immune suppression, and naturally occurring bioactive compounds derived from foodstuff have made a great Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) ISSN 1673-1581 (Print); ISSN 1862-1783 (Online) www.zju.edu.cn/jzus; www.springerlink.com E-mail: jzus@zju.edu.cn contribution as a result of few side-effects and lower toxicity (Gil and Rueda, 2002;Zhang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…As a result of developments in food research, much work has been done on jujube in recent decades and the nature of the polysaccharides present in jujube has been studied (Li et al, 2007;Zhao et al, 2008). On account of the abundance of polysaccharides in jujube, much attention has been directed to their extensive bioactivities in regard to immunomodulation (Zhang et al, 2013), anti-cancer (Plastina et al, 2012), anti-virus (Yen et al, 2014), and anti-oxidation properties (Shen et al, 2009). Although, jujube fruits can be made into paste, puree, syrup, and preparations to aid digestion and general health, deep-processing jujube products are still rare.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:Background: American ginseng (Panax quinquefolius L.) and Chinese jujube (Zizyphus jujuba Mill.) are commonly used in traditional Chinese medicine to enhance immune function. Objective: The present study aimed to develop one Chinese prescription, Shenzao Cha (SZC), consisting of American ginseng and Chinese jujube, and systematically investigate its immunomodulation in healthy ICR mice. Methods: Normal ICR mice received intragastric administration of SZC (1.3, 2.6, and 5.2 g raw material/kg body weight) once daily for four weeks, while a control group received the same amount of sterile water. Results: SZC significantly increased the spleen and thymus indices and T-lymphocyte proliferation, while the T-lymphocyte proliferation in the 5.2 g/kg group was 1.4-fold higher than that in the control. Further, 1.3 g/kg SZC could markedly improve hemolytic activity by 25.2%, and 2.6 g/kg SZC increased the NK cell activity by 78.6% relative to the control. In addition, the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase), that participated in modulating oxidative stress, were significantly increased in the liver, spleen, thymus, and serum, while the contents of malondialdehyde were dramatically decreased. Conclusions: SZC exhibited potent immunomodulatory effects on innate and adaptive immunity in healthy ICR mice, as well as potential antioxidant activity for prevention of oxidative stress, which was suggested to partly contribute to the immune enhancement.

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“…After standing for 48 h, the physical liquor was filtered once more through two-layered gauze, put through a vacuum-rotary evaporation procedure to remove the ethanol, and concentrated into 125ml. APS were purified firstly through eliminating protein by trichloroacetic acid method, and then the APS was dissolved into 50 mg/ml with distilled water, added into a chromatographic column of DEAE-Cellulose-52 (2.5 cm × 30 cm) and eluted with distilled water [11]. The flow rate was maintained at 1 ml/min.…”

Section: Methodsmentioning

confidence: 99%

“…The carbohydrate concentration (%) of APS[calculated based on glucose (C 6 H 12 O 4 )] was determined by the phenol-sulfuric acid method, and the glucose read in 490 nm [12]. The protein content was determined by the Bradford method, and BSA was used as the standard material [11]. …”

Section: Methodsmentioning

confidence: 99%

Optimization and evaluation of astragalus polysaccharide injectable thermoresponsive in-situ gels

Guo

et al. 2017

PLoS ONE

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The objective of this study was to develop an injectable in situ forming gel system based on Poloxamer for sustained release of Astragalus polysaccharide (APS), thus achieved once or twice administration instead of frequent dosing during long-term treatment. The optimal formulation is 10 g APS, 18 g poloxamer 407, 2 g poloxamer 188, 0.15 g CMC-Na, 0.85 g sodium chloride in 100 ml gel in situ which had a preferable sol-gel transition temperature(T sol-gel) (34.1 ± 0.4°C), and good stability. In vitro release studies, all formulations containing polymer additives had prolonged release time and decreased initial burst to some extent. The optimal formulation containing 0.15% CMC-Na showed a best sustained release profile for about 132 h with the lowest initial burst in vitro about 16.30% in 12 h). In vivo, Male BALB/c mice (18–20 g) were administrated with APS in-situ gel just once, the values of immune organ indices, spleen lymphocyte proliferation, and serum IgM, IgG, IL-2 and IL-6 had significant increase, which was consistent with the mice given daily APS injections (7 times), while the above indices were increased more significantly in which administrated with APS in-situ gel twice. Based on these results, it can be concluded that the Poloxamer depot is a promising carrier for the sustained release of APS with an ideal release behavior.

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Immune-enhancing activity comparison of sulfated ophiopogonpolysaccharide and sulfated jujube polysaccharide

Cited by 34 publications

References 27 publications

Functional components in Zizyphus with emphasis on polysaccharides

Functional components in Zizyphus with emphasis on polysaccharides

Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice

Optimization and evaluation of astragalus polysaccharide injectable thermoresponsive in-situ gels

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