Immune‐enhancing effects of Astragalus polysaccharides and Ganoderma lucidum polysaccharides on Vibrio harveyi flgJ DNA vaccine in grouper

Abstract

Pearl gentian grouper (♀Epinephelus fuscoguttatus × ♂E. lanceolatus) is a marine fish with high nutritional value. At present, it has become one of the important reared species in aquaculture of China for its tender meat and high unsaturated fatty acids content. However, with the continuous improvement of intensive cultivation of marine aquaculture in recent years, outbreaks of vibriosis are more and more frequent and cause serious economic loss (Chen et al., 2019; Deng et al., 2020). Vibrio harveyi, the main causative agent of vibriosis, caused high mortality in pearl gentian grouper culture industry in China. In the past decades, antibiotics were used to control V. harveyi because of their good antibacterial efficiency. However, antibiotics abuse leads to the rapid increasing of drug-resistant bacterial strains and the emergence of drug residues (Wei et al., 2020a(Wei et al., , 2020b. In recent years, vaccines were found to be effective against pathogens challenge in fish. The inactivated vaccine, attenuated live vaccine, subunit vaccine and DNA vaccine have been used to control bacteria and virus infection in aquaculture. However, due to different vaccination administration rates or antigen types, poor antigen

The Mechanisms of Polysaccharides from Tonic Chinese Herbal Medicine on the Enhancement Immune Function: A Review

“…PSPC and PSPW [25] can both increase acid phosphatase activity. APS and GLP (a polysaccharide from Ganoderma lucidum) could upregulate the lysozyme activity of pearl gentian grouper, and the combined effect was better [98].…”