Immune enhancing effects of Lactobacillus acidophilus on Newcastle disease vaccination in chickens

Gharajalar, Sahar Nouri; Mirzai, Parisa; Nofouzi, Katayoon; Madadi, Mohammad Sadegh

doi:10.1016/j.cimid.2020.101520

Cited by 13 publications

(8 citation statements)

References 10 publications

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“…Inducing faster vaccine protection is very useful for the body because it will shorten the time between vaccination and exposure, especially during the pandemic or epidemic outbreaks ( 51 ). Previous studies have shown that lactic acid bacteria increased the IgG antibody ( 52 ) and the SIgA antibody ( 53 ), which is consistent with our research. Similarly, Khattab et al.…”

Section: Discussionsupporting

confidence: 93%

Nano selenium-enriched probiotic Lactobacillus enhances alum adjuvanticity and promotes antigen-specific systemic and mucosal immunity

Liu

Sun²,

Sun³

et al. 2023

Front. Immunol.

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Nano selenium-enriched probiotics have been identified to improve immune responses, such as alleviating inflammation, antioxidant function, treatment of tumors, anticancer activity, and regulating intestinal flora. However, so far, there is little information on improving the immune effect of the vaccine. Here, we prepared nano selenium-enriched Levilactobacillus brevis 23017 (SeL) and heat-inactivated nano selenium-enriched L. brevis 23017 (HiSeL) and evaluated their immune enhancing functions on the alum-adjuvanted, inactivated Clostridium perfringens type A vaccine in mouse and rabbit models, respectively. We found that SeL enhanced immune responses of the vaccine by inducing a more rapid antibody production, eliciting higher immunoglobulin G (IgG) antibody titers, improving secretory immunoglobulin A (SIgA) antibody level and cellular immune response, and regulating Th1/Th2 immune response, thus helping to induce better protective efficacy after challenge. Moreover, we confirmed that the immunoenhancement effects are related to regulating oxidative stress, cytokine secretion, and selenoprotein expression. Meanwhile, similar effects were observed in HiSeL. In addition, they show enhanced humoral immune response at 1/2 and 1/4 standard vaccine doses, which confirms their prominent immune enhancement effect. Finally, the effect of improving vaccine immune responses was further confirmed in rabbits, which shows that SeL stimulates the production of IgG antibodies, generates α toxin–neutralizing antibodies rapidly, and reduces the pathological damage to intestine tissue. Our study demonstrates that nano selenium-enriched probiotics improve the immune effect of the alum adjuvants vaccine and highlight its potential usage in remedying the disadvantages of alum adjuvants.

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Section: Discussionsupporting

confidence: 93%

Nano selenium-enriched probiotic Lactobacillus enhances alum adjuvanticity and promotes antigen-specific systemic and mucosal immunity

Liu

Sun²,

Sun³

et al. 2023

Front. Immunol.

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“…As a matter of fact, very recently, it has been shown that a range of probiotic bacteria increases the efficacy of vaccinations in chickens treated with a vaccine specific for Newcastle disease [ 26 ] or avian influenza H9N2 [ 27 , 28 ]. In this case, adjuvant effects have been detected by using either bacteria cells [ 9 ] or spores [ 27 ].…”

Section: Animal Vaccinationsmentioning

confidence: 99%

Probiotics as Adjuvants in Vaccine Strategy: Is There More Room for Improvement?

Peroni

Morelli

2021

Vaccines

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Background. It has been recognized that microbiota plays a key role in shaping immune system maturation and activity. Since probiotic administration influences the microbiota composition and acts as a biological response modifier, the efficacy of an adjuvant for boosting vaccine-specific immunity is investigated. Methods. A review of the literature was performed, starting from the mechanisms to laboratory and clinical evidence. Results. The mechanisms, and in vitro and animal models provide biological plausibility for microbiota use. Probiotics have been investigated as adjuvants in farm conditions and as models to understand their potential in human vaccinations with promising results. In human studies, although probiotics were effective in ameliorating seroconversion to vaccines for influenza, rotavirus and other micro-organisms, the results for clinical use are still controversial, especially in particular settings, such as during the last trimester of pregnancy. Conclusion. Although this topic remains controversial, the use of probiotics as adjuvant factors in vaccination represents a strategic key for different applications. The available data are deeply influenced by heterogeneity among studies in terms of strains, timing and duration of administration, and patients. Although these do not allow us to draw definitive conclusions, probiotics as adjuvants in vaccination should be considered in future studies, especially in the elderly and in children, where vaccine effectiveness and duration of immunization really matter.

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“…Thus, Bron et al [83], after analyzing the available data on the adjuvant activity of three strains of lactobacilli, noted a role in improving vaccination efficacy in compounds such as lipoteichoic acid in Lactiplantibacillus plantarum, the GG (also known as LGG) proteins p40 and p75 secreted by Lacticaseibacillus rhamnosus, and surface layer protein A (SlpA) in L. acidophilus strain NCFM. Earlier results in poultry have also shown that a number of probiotic bacteria increase efficacy against Newcastle disease [84] and avian influenza [85].…”

Section: Discussionmentioning

confidence: 93%

Bioactive Feed Additive for the Prevention of Clostridial Disease in High-Yielding Dairy Cattle

et al. 2023

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The purpose of this research is to develop and test a new approach to prevent clostridial disease in cattle, based on the use of a new compound biologically active feed additive (BFA). Some properties of the separate components of BFA are characterized. The research showed that a strain of the bacterium Bacillus amyloliquefaciens159 has an expressed antagonism to toxin-producing strains of C. perfringens. When using the test strains of C. perfringens from the ATCC collection (13124 as type A, 10543 as type C, 12916 as type F), the anticlostridial activity of the tested strains varied, with size range of 14.0 ± 0.95–15.0 ± 1.28 mm of delayed growth zones. The bactericidal properties of lauric acid and the sorption properties of diatomaceous earth, included in BFA, were confirmed. The experiment was conducted on Holstein cows at the beginning of lactation (control, C (n = 15) vs. experimental E48 (n = 15), E80 (n = 15) and E112 (n = 15), 48, 80 and 112 g/head/day BFA, respectively. All cows were vaccinated with “Coglavax” (vaccine against bovine and sheep clostridial disease, Ceva-Phylaxia VeterinaryBiologicals, Hungary), reinjected two weeks before the experiment. At the end of the experiment (3.5 months after the vaccination and 3 months after the start of BFA feeding according to the scheme of the experiment), the immune response in the control and Group E48 to C. perfringens β-toxin remained at the initial level, while the response in Group E80 and Group E112 became higher under the influence of BFA feeding. Cows fed BFA saw a guaranteed improvement in non-specific resistance. The increase in serum lysozyme concentration in cows of Groups E was 1.01–2.91 mkg/mL vs. control (p < 0.001). TP, GLB, ALB/GLB vs. Groups C and E48 (p < 0.001); this stabilized and normalized while feeding Group E80 and E112 animals with BFA. They also had improved nitrogen, fat, mineral metabolism, as indicated by significant increase in ALB (p < 0.05), UREA (p < 0.01), CHOL (p < 0.01), and CHL (p < 0.01) vs. Groups C and E48. Consumption of BFA increased the amount of anti-oxidants in the blood (highest TAWSA values in Group E80 14.45 mg/g, p = 0.002). Serum TBA–AP/ CP ratio was directly related to TBA–AP (r = 0.87, p < 0.001), and decreased in Group E80. The milk productivity increased under the action of BFA; the average daily milk yield of the cows from the experimental groups for the period of the experiment (d0-d98) was 1.24–1.66 kg higher than that of the control. At the same time, Group E112 cows had a significant increase in milk yield (by 5.1%, p = 0.03 vs. Control). Thus, feeding BFA to dairy cows was found to improve resistance, prevent toxicoses and increase milk production of cattle, which can serve as an additional strategy for bioprotection of cattle against infection.

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Immune enhancing effects of Lactobacillus acidophilus on Newcastle disease vaccination in chickens

Cited by 13 publications

References 10 publications

Nano selenium-enriched probiotic Lactobacillus enhances alum adjuvanticity and promotes antigen-specific systemic and mucosal immunity

Nano selenium-enriched probiotic Lactobacillus enhances alum adjuvanticity and promotes antigen-specific systemic and mucosal immunity

Probiotics as Adjuvants in Vaccine Strategy: Is There More Room for Improvement?

Bioactive Feed Additive for the Prevention of Clostridial Disease in High-Yielding Dairy Cattle

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