Immune-enhancing effects of postbiotic produced by Bacillus velezensis Kh2-2 isolated from Korea Foods

Mi, Xiao-jie; Tran, Thi Hoa; Park, Hye-Ryung; Xu, Xing; Subramaniyam, Sathiyamoorthy; Choi, Han Sol; Kim, Jin A; Koh, Sung-Cheol; Kim, Yeon Ju

doi:10.1016/j.foodres.2021.110911

Cited by 20 publications

(8 citation statements)

References 59 publications

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“…Given this, the possible benefits of the use of postbiotics and paraprobiotics were raised, which led to increased interest in their development and applications. Therefore, there has been increased research on postbiotics and paraprobiotics, as well as commercial and medical interest, which have become an alternative for the development of functional foods with many advantages about live probiotics (e.g., ease of storage and increased shelf life) [ 35 ]. Table 3 presents some recent applications of paraprobiotics and postbiotics with beneficial results for human health.…”

Section: Resultsmentioning

confidence: 99%

Paraprobiotics and Postbiotics—Current State of Scientific Research and Future Trends toward the Development of Functional Foods

Monteiro

Schnorr

Pasquali

2023

Foods

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The potential of paraprobiotics and postbiotics to be used as beneficial agents for human health has caused an effort by the scientific community to gather information about the bioactivity of these compounds and production methods. Understanding the evolution of scientific research in this area of study is important to understand the future perspectives and the main bottlenecks of scientific and technological development involving these compounds. In this scenario, this review work used a bibliometric analysis tool intending to improve the scientific documentation, bringing information and communicating the results to the scientific community through the quantitative analysis of the current literature, available in one of the main databases, the Web of Science, also providing recent information on the evolution and future perspectives in the field of paraprobiotic and postbiotic development. The results of this study showed that the main studies discuss the bioactivity of these compounds. Concerning the development of functional foods, there is a need for extensive research on production methods and the interaction of these compounds with food. However, it concluded that much still needs to be studied to prove the claims of bioactivity, especially when used for the development of functional foods.

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Section: Resultsmentioning

confidence: 99%

Paraprobiotics and Postbiotics—Current State of Scientific Research and Future Trends toward the Development of Functional Foods

Monteiro

Schnorr

Pasquali

2023

Foods

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“…® Soil DNA Kit (Omega Biotek, Norcross, GA, USA) following the manufacturer’s protocol. The sequencing procedure was identical to that followed in our previous study ( 5 ).…”

Section: Methodsmentioning

confidence: 99%

“…Probiotics are known to provide numerous benefits to human health as living microorganisms. Particularly, they are recognized for their crucial features such as immune system enhancement, prevention of gastrointestinal infections, and protection against oxidative stress ( 5 ). However, along with these benefits, probiotics may induce side effects in specific population groups, and issues related to their viability, stability, and sensitivity to storage conditions are also associated ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Paraprobiotic derived from Bacillus velezensis GV1 improves immune response and gut microbiota composition in cyclophosphamide-treated immunosuppressed mice

Lee,

Tran,

et al. 2024

Front. Immunol.

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Paraprobiotics that benefit human health have the capacity to modulate innate and adaptive immune systems. In this study, we prepared the paraprobiotic from Bacillus velezensis GV1 using the heat-killing method and investigated its effects on immunity and gut microbiota in vitro and in vivo. The morphology of inactivated strain GV1 was observed using scanning electron microscopy. Treatment with GV1 promoted nitric oxide production and augmented cytokine (IL-6, IL-1β, and TNF-α) expression and secretion in RAW 264.7 macrophages. Moreover, the strain GV1 could alleviate cyclophosphamide monohydrate (CTX)-induced immunosuppression by reversing spleen damage and restoring the immune organ index, as well as by increasing the expression of immune-related cytokines (TNF-α, IL-1β, IFN-γ, and IL-2) in the spleen and thymus, respectively. Furthermore, GV1 treatment dramatically healed the CTX-damaged colon and regulated gut microbiota by increasing the relative abundance of beneficial bacterial families (Lactobacillaceae, Akkermansiaceae, and Coriobacteriaceae) and decreasing that of harmful bacterial families (Desulfovibrionaceae, Erysipelotrichaceae, and Staphylococcaceae). Thus, the heat-killed GV1 can be considered a potential immunoregulatory agent for use as a functional food or immune-enhancing medicine.

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“…This probably results by correcting the gut microbiome, improving intestinal barrier integrity, modulating local & systemic immune response, regulating immune cells functions, reducing inflammation, and inhibiting the growth of pathogens (Zakostelska et al, 2011;Russo et al, 2019). Mi et al (2022) observed the immune enhancing effect of cell lysate from Bacillus velezensis (Kh 2-2) derived from Korean fermented food Squid Jeotgal through in vivo, in vitro, and ex vivo studies. The lysate was reported to increase the cytokine production, promote specific and nonspecific immune responses and activate macrophages.…”

Section: Bacterial Lysatesmentioning

confidence: 99%

Postbiotics: From emerging concept to application

Aggarwal

Sabharwal

Kaushik

et al. 2022

Front. Sustain. Food Syst.

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The microbiome innovation has resulted in an umbrella term, postbiotics, which refers to non-viable microbial cells, metabolic byproducts and their microbial components released after lysis. Postbiotics, modulate immune response, gene expression, inhibit pathogen binding, maintain intestinal barriers, help in controlling carcinogenesis and pathogen infections. Postbiotics have antimicrobial, antioxidant, and immunomodulatory properties with favorable physiological, immunological, neuro-hormonal, regulatory and metabolic reactions. Consumption of postbiotics relieves symptoms of various diseases and viral infections such as SARS-CoV-2. Postbiotics can act as alternatives for pre-probiotic specially in immunosuppressed patients, children and premature neonates. Postbiotics are used to preserve and enhance nutritional properties of food, elimination of biofilms and skin conditioning in cosmetics. Postbiotics have numerous advantages over live bacteria with no risk of bacterial translocation from the gut to blood, acquisition of antibiotic resistance genes. The process of extraction, standardization, transport, and storage of postbiotic is more natural. Bioengineering techniques such as fermentation technology, high pressure etc., may be used for the synthesis of different postbiotics. Safety assessment and quality assurance of postbiotic is important as they may induce stomach discomfort, sepsis and/or toxic shock. Postbiotics are still in their infancy compared to pre- and pro- biotics but future research in this field may contribute to improved physiological functions and host health. The current review comprehensively summarizes new frontiers of research in postbiotics.

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Immune-enhancing effects of postbiotic produced by Bacillus velezensis Kh2-2 isolated from Korea Foods

Cited by 20 publications

References 59 publications

Paraprobiotics and Postbiotics—Current State of Scientific Research and Future Trends toward the Development of Functional Foods

Paraprobiotics and Postbiotics—Current State of Scientific Research and Future Trends toward the Development of Functional Foods

Paraprobiotic derived from Bacillus velezensis GV1 improves immune response and gut microbiota composition in cyclophosphamide-treated immunosuppressed mice

Postbiotics: From emerging concept to application

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