2024
DOI: 10.1038/s41541-024-00905-0
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Immune escape of avian oncogenic Marek’s disease herpesvirus and antagonistic host immune responses

Zhi-Jian Zhu,
Man Teng,
Yu Liu
et al.

Abstract: Marek’s disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek’s disease (MD), which is one of the most important immunosuppressive and rapid-onset neoplastic diseases in poultry. The onset of MD lymphomas and other clinical diseases can be efficiently prevented by vaccination; these vaccines are heralded as the first demonstration of a successful vaccination strategy against a cancer. However, the persistent evolution of epidemic MDV strains towards greater virulence has … Show more

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