Immune Factors, Immune Cells and Inflammatory Diseases

Ward, Alister C.

doi:10.3390/ijms25042417

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Possible Anti-inflammatory Mechanism Of Apoa-i1

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2024

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“…The inflammatory response is primarily determined on the function and activity of immune cells ( 36 ). Monocytes are an important component of the defense system of body, which play a crucial role in the immune system, and can induce a specific immune response in lymphocytes through antigen presentation ( 37 ).…”

Section: Possible Anti-inflammatory Mechanism Of Apoa-imentioning

confidence: 99%

Anti-inflammatory mechanism of Apolipoprotein A-I

Tao,

Wang

et al. 2024

Front. Immunol.

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Apolipoprotein A-I(ApoA-I) is a member of blood apolipoproteins, it is the main component of High density lipoprotein(HDL). ApoA-I undergoes a series of complex processes from its generation to its composition as spherical HDL. It not only has a cholesterol reversal transport function, but also has a function in modulating the inflammatory response. ApoA-I exerts its anti-inflammatory effects mainly by regulating the functions of immune cells, such as monocytes/macrophages, dendritic cells, neutrophils, and T lymphocytes. It also modulates the function of vascular endothelial cells and adipocytes. Additionally, ApoA-I directly exerts anti-inflammatory effects against pathogenic microorganisms or their products. Intensive research on ApoA-I will hopefully lead to better diagnosis and treatment of inflammatory diseases.

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Section: Possible Anti-inflammatory Mechanism Of Apoa-imentioning

confidence: 99%