Immune Function and Immunizations in Dialyzed Children

Chua, Annabelle N.; Neu, Alicia M.

doi:10.1007/978-1-4614-0721-8_28

Cited by 1 publication

(2 citation statements)

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“…Among SOT patients, the induction and maintenance of antibodies upon vaccination might be reduced due to the immunosuppressive treatment they take to avoid graft rejection [ 32 ]. In COPD and CKD patients, vaccine immunology can be impaired by disrupted innate and adaptive immune responses caused by chronic inflammation of the airways and uremic state, respectively [ 33 , 34 , 35 ]. For HIV patients, reduced vaccine immune response is mostly seen in those with a low CD4-cell count, a detectable viral load and in those not using anti-retroviral therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Vaccination is the best available tool to prevent infectious diseases, even when vaccine immunity is reduced due to age, disease or treatment. It still has the benefit of reducing the likelihood of acquiring severe disease, such as pertussis infection requiring hospitalization or resulting in post-tussive vomiting [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. Since patients with chronic disease are often followed by a specialist, an appropriate recommendation by the treating specialist may convince them to get their vaccine with their general practitioner.…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients

et al. 2021

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Patients with chronic diseases are at increased risk of complications following infection. It remains, however, unknown to what extend they are protected against vaccine-preventable diseases. We assessed seroprevalence of antibodies against diphtheria, tetanus and pertussis to evaluate whether current vaccination programs in Belgium are adequate. Antibody titers were assessed with a bead-based multiplex assay in serum of 1052 adults with chronic diseases. We included patients with diabetes mellitus type 1 (DM1) (n = 172), DM2 (n = 77), chronic kidney disease (n = 130), chronic obstructive pulmonary disease (COPD) (n = 170), heart failure (n = 77), HIV (n = 196) and solid organ transplant (SOT) recipients (n = 230). Factors associated with seroprevalence were analysed with multiple logistic regression. We found seroprotective titers in 29% for diphtheria (≥0.1 IU/mL), in 83% for tetanus (≥0.1 IU/mL) and 22% had antibodies against pertussis (≥5 IU/mL). Seroprotection rates were higher (p < 0.001) when vaccinated within the last ten years. Furthermore, diphtheria seroprotection decreased with age (p < 0.001). Tetanus seroprotection was less reached in women (p < 0.001) and older age groups (p < 0.001). For pertussis, women had more often a titer suggestive of a recent infection or vaccination (≥100 IU/mL, p < 0.01). We conclude that except for tetanus, the vast majority of at-risk patients remains susceptible to vaccine-preventable diseases such as diphtheria and pertussis.

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