Immune hallmarks of rheumatoid arthritis management: A brief review

Peixoto, Rephany Fonseca; Rodrigues, Carlos Ewerton Maia; Palmeira, Pedro Henrique de Sousa; Santos, Fernando Cézar Comberlang Queiroz Davis dos; Lima, Tatjana Keesen de Souza; Braz, Alessandra de Sousa

doi:10.1016/j.cyto.2022.156007

Cited by 8 publications

(2 citation statements)

References 116 publications

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“…Unfortunately, the pathogenesis of RA has not been fully illustrated, which poses a major challenge to the treatment of RA. At present, nonsteroidal anti-inflammatory drugs (NSAIDs) (Bindu et al, 2020) and disease-modifying anti-rheumatic drugs (DMARDs) (Fonseca Peixoto et al, 2022) are common treatments for RA. However, traditional NSAIDs and DMARDs have significant gastrointestinal, hepatic, and renal toxicity (Min et al, 2022), glucocorticoids can cause side effects such as osteoporosis, hypertension, and hyperglycemia, while biologics can cause autoimmune syndromes .…”

Section: Introductionmentioning

confidence: 99%

Identification of the active compounds and their mechanisms of medicinal and edible Heigen based on UHPLC-Q-Exactive Orbitrap MS and network pharmacology

Zhao

Ding

et al. 2023

Food Sci. Technol

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Heigen is the root and rhizomes of Duhaldea Nervosa Anderberg., a traditional medicine food homology herb used to treat rheumatoid arthritis in China,but the potential active components and the underlying mechanism have not been clarified. In this study, the chemical compounds and the components absorbed into the blood from Heigen were assessed using ultrahigh performance liquid chromatography coupled with quadrupole Orbitrap high-resolution mass spectrometry. 72 chemical constituents were identified in Heigen, 13 blood prototypical constituents, and 9 metabolites were found in serum samples after intragastric administration of Heigen extracts to rats. Then, using network pharmacology and molecule docking, 10 compounds were assumed to be potentially key active compounds against RA, which may be via the multi-component, multi-target and multi-pathway interaction mechanism of Heigen in the treatment of RA, and also provides a pharmacological basis for the treatment of RA.

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Section: Introductionmentioning

confidence: 99%

Identification of the active compounds and their mechanisms of medicinal and edible Heigen based on UHPLC-Q-Exactive Orbitrap MS and network pharmacology

Zhao

Ding

et al. 2023

Food Sci. Technol

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“…El componente principal en la susceptibilidad al desarrollo de AR se encuentra en el complejo mayor de histocompatibilidad (MHC) 7,8,9 . Desde el punto de vista inmunológico, se han descrito diversos anticuerpos asociados a RA y sólo algunos de estos son específicos, entre los que se encuentran el Factor Reumatoídeo (FR) y los anticuerpos dirigidos contra proteínas y/o péptidos citrulinados 10 . Los anticuerpos más citados en diferentes estudios son: Anticuerpos dirigidos contra antígenos de los cartílagos como el colágeno de tipo II y la glicoproteína-39 del cartílago humano; Anticuerpos dirigidos contra enzimas de la ruta glicolítica como la glucosa-6fosfato isomerasa y la creatinina quinasa; Anticuerpos dirigidos contra inmunoglobulinas como el FR; Anticuerpos dirigidos contra proteínas y/o péptidos citrulinados como la filagrina, el fibrinógeno y la vimentina; Anticuerpos antinucleares (ANAs) y Anticuerpos anti-citoplasma de neutrófilos (ANCAs) 11,12,13,14,15,16,17,18 .…”

Section: Introductionunclassified

Dietoterapia en artritis reumatoide: Revisión de la evidencia

Castillo,

Bravo

2023

Rev. chil. nutr.

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Intervenciones dietarias en artritis reumatoideEn los últimos años se han propuesto numerosas intervenciones alimentarias como tratamiento 19,20,21 , ya sea como protocolos dietarios, suplementos y alimentos que tendrían un efecto positivo en marcadores inflamatorios, calidad de vida o discapacidad autopercibida medido por ABSTRACT Rheumatoid arthritis (RA) is a chronic rheumatic disease characterised by progressive joint damage and extra-articular manifestations that can lead to disability. The aetiology of autoimmune diseases, including RA, is complex, involving genetic, hormonal, dietary, and environmental factors. However, the physiological mechanisms by which these agents contribute to pathogenesis have not yet been fully defined. More recent studies suggest an impact of gut microbiome dysbiosis on the pathogenesis of autoimmune diseases in both animal and human models, including rheumatoid arthritis, also suggesting altered intestinal permeability as a possible cause. This modification of the gut microbiome may be related to influential diet patterns in the prevention of this pathology, as well as a proposed complementary treatment to traditional pharmacological treatment, also considering the increased risk for these patients of developing metabolic syndrome and "rheumatoid cachexia", an accumulation of adipose tissue accompanied by a decrease in muscle tissue due to catabolic changes due to chronic inflammation and physical inactivity as a consequence of motor difficulties in RA. With the emergence of recent evidence proposing dietary interventions and eating patterns as adjunctive treatment to drug therapy in the management of RA, the following narrative qualitative review proposes reviewing recent evidence on the effectiveness of various proposed dietary interventions in the treatment of rheumatoid arthritis in terms of pain and disease activity, finding between a high heterogeneity of proposed interventions, those dietary patterns with modulating effect on the gut microbiome as Mediterranean diet and its variations in the context of promoting a healthy lifestyle would be positive as a complementary therapy for this disease.

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FOXA2 inhibits the TLR4/NF-κB signaling pathway and alleviates inflammatory activation of macrophages in rheumatoid arthritis by repressing LY96 transcription

Cao,

Yang

2024

Cytokine

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Immune hallmarks of rheumatoid arthritis management: A brief review

Cited by 8 publications

References 116 publications

Identification of the active compounds and their mechanisms of medicinal and edible Heigen based on UHPLC-Q-Exactive Orbitrap MS and network pharmacology

Identification of the active compounds and their mechanisms of medicinal and edible Heigen based on UHPLC-Q-Exactive Orbitrap MS and network pharmacology

Dietoterapia en artritis reumatoide: Revisión de la evidencia

FOXA2 inhibits the TLR4/NF-κB signaling pathway and alleviates inflammatory activation of macrophages in rheumatoid arthritis by repressing LY96 transcription

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