Immune hemolytic anemia—selected topics

Hoffman, Philip C.

doi:10.1182/asheducation-2009.1.80

Cited by 63 publications

(23 citation statements)

References 54 publications

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“…In fact up-to-date no experience was reported in case of PLS after LT. It is likely thatas our experience with the drug evolves, it will be used atan earlier point in therapy, before more toxic immunosuppressives, rather than only in refractory cases [19, 20]. …”

Section: Treatment For Plsmentioning

confidence: 99%

Passenger Lymphocyte Syndrome and Liver Transplantation

Audet

Panaro

Piardi

et al. 2008

Clinical and Developmental Immunology

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The authors reviewed the passenger lymphocyte syndrome (PLS) that has appeared after transplantation. The definition, mechanism, serological, clinical features, and treatment for PLS after solid organ transplantation, especially liver transplantation, are described. The PLS refers to the clinical phenomenon of alloimmune hemolysis resulting from the adoptive transfer of viable lymphocytes from donor during solid organ or hematopoietic stem cell transplant. Sometimes, it is very severe and may cause “unexplained” hemolysis during the postoperative period. The authors reviewed literature about the PLS in liver transplantation.

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Section: Treatment For Plsmentioning

confidence: 99%

Passenger Lymphocyte Syndrome and Liver Transplantation

Audet

Panaro

Piardi

et al. 2008

Clinical and Developmental Immunology

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“…Research in the past several years has increasingly suggested that autoimmune diseases may be risk factors for VTE occurrence [4]. These have included studies that have reported a higher risk of VTE associated with autoimmune hemolytic anemia (AIHA), immune thrombocytopenic purpura (ITP), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE), as well as several other autoimmune diseases [5–11].…”

Section: Introductionmentioning

confidence: 99%

Risk of venous thromboembolism among hospitalizations of adults with selected autoimmune diseases

Yusuf

Hooper

Beckman

et al. 2014

J Thromb Thrombolysis

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Previous research has suggested autoimmune diseases are risk factors for developing venous thromboembolism (VTE). We assessed whether having diagnoses of selected autoimmune diseases associated with anti-phospholipid antibodies—autoimmune hemolytic anemia (AIHA), immune thrombocytopenic purpura (ITP), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE)—were associated with having a VTE diagnosis among US adult hospitalizations. A cross-sectional study was conducted using the 2010 Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality. VTE and autoimmune diseases were identified using International Classification of Diseases, Ninth Revision, Clinical Modification coded diagnoses information. The percentages of hospitalizations with a VTE diagnosis among all non-maternal adult hospitalizations without any of the four autoimmune diseases of interest and among those with AIHA, ITP, RA, and SLE diagnoses were 2.28, 4.46, 3.35, 2.65 and 2.77 %, respectively. The adjusted odds ratios (OR) for having a diagnosis of VTE among non-maternal adult hospitalizations with diagnoses of AIHA, ITP, RA, and SLE were 1.25 [95 % confidence interval (CI) 1.05–1.49], 1.20 (95 % CI 1.07–1.34), 1.17 (95 % CI 1.13–1.21), and 1.23 (95 % CI 1.15–1.32), respectively, when compared to those without the corresponding conditions. The adjusted OR for a diagnosis of VTE associated with a diagnosis of any of the four autoimmune diseases was 1.20 (95 % CI 1.16–1.24). The presence of a diagnosis of AIHA, ITP, RA, and SLE was associated with an increased likelihood of having a VTE diagnosis among the group of all non-maternal adult hospitalizations.

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“…(33-35) However, its use is indicated only when the use of corticosteroids fails or there are absolute contraindications to its use and in cases where there is disease relapse after splenectomy (Recommendation: Grade C; Evidence: level III). (36,37) …”

Section: "Off-label" Indications For Ig Usementioning

confidence: 99%

Clinical applications of immunoglobulin

Novaretti

Dinardo

2011

Rev. Bras. Hematol. Hemoter.

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Human immunoglobulin is the most used blood product in the clinical practice. Immunoglobulin applications have increased quickly since the elucidation of its immunomodulatory and antiinflammatory properties which turned this blood product into a precious tool in the treatment of numerous diseases that present with humoral immune deficiency or that cause immune system dysfunction. Currently, the approved indications for Ig are: primary immunodeficiencies, secondary immunodeficiencies (multiple myeloma or chronic lymphoid leukemia), Kawasaki syndrome, immune thrombocytopenic purpura, Guillain Barré syndrome, graft-versus-host disease following bone marrow transplantation and repeat infections in HIV children. On the other hand, there are numerous "off-label" indications of immunoglobulin, which represent 20-60% of all clinical applications of this drug. It is important to study all these indications and, above all, the scientific evidence for its use, in order to provide patients with a new therapeutic option without burdening the health system. This review results from a wide selection of papers identified in the Pubmed and Lilacs scientific electronic databases. A group of descriptors were used from human immunoglobulin to the names of each disease that immunoglobulin is clinically applied. Our main objective is to list the numerous indications of immunoglobulin, both authorized and "off-label" and to analyze these indications in the light of the most recent scientific evidence.

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Immune hemolytic anemia—selected topics

Cited by 63 publications

References 54 publications

Passenger Lymphocyte Syndrome and Liver Transplantation

Passenger Lymphocyte Syndrome and Liver Transplantation

Risk of venous thromboembolism among hospitalizations of adults with selected autoimmune diseases

Clinical applications of immunoglobulin

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