Immune History Modifies Disease Severity to HPAI H5N1 Clade 2.3.4.4b Viral Challenge
Pamela H. Brigleb,
Bridgett Sharp,
Ericka Kirkpatrick Roubidoux
et al.
Abstract:The most recent outbreak of highly pathogenic avian H5 influenza (HPAI) virus in cattle is now widespread across the U.S. with spillover events happening to other mammals, including humans. Several human cases have been reported with clinical signs ranging from conjunctivitis to respiratory illness. However, most of those infected report mild to moderate symptoms, while previously reported HPAI H5Nx infections in humans have had mortality rates upwards of 50%. We recently reported that mice with pre-existing i… Show more
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