Immune Infertility and New Approaches to Treatment

Second Pregnancies Among Immunologically Infertile Women: A Preliminary Report

“…Various methods of therapy have been described and developed, but it seems that the method devised by Shulman et al [4] is the most successful at this time.…”

“…Highdose corticosteroid therapy, as advocated by Shulman et al [4], is an effective treatment for infertility caused by sperm antibodies in both the male and female [l, 3, 4, 71. This study reports the results of two immunologically infertile females who were successfully treated with high dosages of corticosteroids and who conceived on two different occasions during therapy.…”

The Impact ofIn VitroFertilization on Male Infertility

“…Although the presence of such antibodies is especially prevalent in patients who have undergone vasectomy reversal, this condition may also be found to be increased in the general infertile male population. 9 A variety of techniques have been used in the treatment of antisperm antibodies, including high-dose oral corticosteroids of various concentrations and durations; sperm processing, 10 such as sperm washing [11][12][13] ; and modified methods of semen collection, such as ejaculation directly into buffered medium. Although the results of these techniques have been variable, no modality used to date has resulted in a consistently high degree of success.…”

Sperm Cervical Mucus Contact Test and Immunobead Test for Sperm Antibodies

“…The IBT was performed as devised and described by Clarke et al [3,41 and Shulman et al [12]. A 4 % solution of human serum albumin (HSA) was prepared.…”