Immune infertility in men

Leathersich, Sebastian; Hart, Roger

doi:10.1016/j.fertnstert.2022.02.010

Cited by 15 publications

(11 citation statements)

References 144 publications

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“…IgA predominates at mucosal surfaces and secretions, including seminal plasma and cervical mucus, whereas immunoglobulin G (IgG) predominates in serum. Both might be bound to sperm surface antigens 96 . A study reported that a part of sperm cells bound to HPV DNA with ASAs was more frequently found in the sperm of infertile patients compared to control.…”

Section: Hpv Semen Infection and Asamentioning

confidence: 99%

“…It is widely acknowledged that infertility in humans and other mammals is caused by a subpopulation of ASA that bind to sperm antigens 100 . The most effective treatment for ASA‐related fertility impairment appears to be ICSI, which produces results comparable to those of ASA‐negative patients regarding fertilization rates, clinical pregnancy rates, embryonic development, and live birth rates 96 …”

Section: Hpv Semen Infection and Asamentioning

confidence: 99%

“…100 The most effective treatment for ASA-related fertility impairment appears to be ICSI, which produces results comparable to those of ASA-negative patients regarding fertilization rates, clinical pregnancy rates, embryonic development, and live birth rates. 96…”

Section: Hpv Semen Infection and Asamentioning

confidence: 99%

“…Both might be bound to sperm surface antigens. 96 A study reported that a part of sperm cells bound to HPV DNA with ASAs was more frequently found in the sperm of infertile patients compared to control. When immunostaining was done on the samples and observed under a confocal microscope, a costaining of IgG and IgA was found in ASA + infected samples while it was absent in ASA − samples.…”

Section: Hpv Semen Infection and Asamentioning

confidence: 99%

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The impact of human papilloma virus on human reproductive health and the effect on male infertility: An updated review

Das

Fletcher

et al. 2023

Journal of Medical Virology

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It is believed that human papilloma virus infection (HPV), which is caused by the DNA virus, is the most prominent factor contributing to sexually transmitted disease (STD) in the world, with males having a prevalence rate of 3.5%-45% while that women are 2%-44%. Infertility is a rising problem on a global basis, affecting anywhere from 10% to 30% of couples who have reached reproductive age. This study aims to investigate the existing research on HPV, its connection to male infertility, and how it could be a helpful tool for medical professionals managing HPV in the context of reproductive health care. Infection with HPV has been identified as a risk factor for several spontaneous abortions; however, there is a lack of evidence on how HPV influences individuals undergoing assisted reproductive technology (ART) in terms of live births. The significance of the immune response to HPVinfected male reproductive system cells and its effect on embryos, as well as the oxidative stress generated by high-risk HPV DNA damage and genomic instability, is discussed in this review. Further, the association between male individuals infected with HPV and asthenozoospermia should provide a compelling case for vaccinating young people against HPV.

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Section: Hpv Semen Infection and Asamentioning

confidence: 99%

Section: Hpv Semen Infection and Asamentioning

confidence: 99%

Section: Hpv Semen Infection and Asamentioning

confidence: 99%

Section: Hpv Semen Infection and Asamentioning

confidence: 99%

See 2 more Smart Citations

The impact of human papilloma virus on human reproductive health and the effect on male infertility: An updated review

Das

Fletcher

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…An sonohysterography improves visualisation of the endometrium and uterine pathology A semen analysis, which is performed in a specialised andrology laboratory, can also provide information about antisperm antibodies, which can reduce chances of natural conception. 19 The concentration and motility of sperm are the most important parameters for spontaneous conception, and morphology is least predictive. There is variability in semen parameters, and men with a result outside of the reference range should be retested after at least 2-3 months because of the progression of spermatogenesis.…”

Section: Not Just a Female Problemmentioning

confidence: 99%