Immune-inflammatory markers in remission after a first-episode psychosis in young patients

Zozulya, S A; Tikhonov, D. V.; Каледа, В Г; Klyushnik, T. P.

doi:10.17116/jnevro202112106159

Cited by 12 publications

(4 citation statements)

References 14 publications

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“…Thus, group 2, where psychosis developed in patients more than two months after COVID-19, showed increases in blood activity of both LE (p < 0.05) and its inhibitor α1-PI (p < 0.001). Increases in the activity of acute-phase proteins, of which α1-PI is a representative, as well as the proteolytic enzyme LE, which refl ects an increase in neutrophil degranulation activity, characterize "typical" infl ammation aimed at restoring disturbed homeostasis and are consistent with the results of our previous studies [20,21]. The increase in α1-PI activity may refl ect an acute-phase response caused by a previous COVID-19 infection, which ological infl ammatory process common to the pathogenesis of both infection-related and endogenous mental illness.…”

supporting

confidence: 88%

“…Thus, the overall results indicate that endogenous psychosis developing longer after coronavirus infection is associated with a "typical" infl ammatory reaction, with increases in the acute phase protein activities and neutrophil degranulation activity, which are associated with the development of depressive-delusional states in patients with predominance of the manifestations of positive affectivity (anxiety, melancholy) and the developed nature of delusional disorders. In terms of the levels of the infl ammatory mediators studied here, immune profi les did not differ from those previously identifi ed in other cohorts of patients with endogenous psychoses [20,21].…”

supporting

confidence: 43%

“…Our own studies have shown that LE activity refl ects the activity of the ongoing pathological process in the brain in endogenous psychoses, and this has repeatedly been confi rmed by the fi nding of correlations between the severity of patients' clinical condition and enzyme activity [20,21].…”

mentioning

confidence: 78%

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Clinical-Immunological Correlates in Post-COVID-19 Endogenous Psychoses

Zozulya

Сизов

Олейчик

et al. 2023

Neurosci Behav Physi

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Objectives. To carry out a clinical and immunological study of the potential impact of coronavirus infection on the course of endogenous psychoses. Materials and methods. A total of 33 female patients aged 16-48 years with depressive-delusional states (F20.01, F21, F31) developing after coronavirus infections took part; group 1 consisted of 15 people who developed depressive-delusional states 1-2 months after COVID-19; group 2 consisted of 18 people with similar psychoses developing at later time points (2-6 months). The severity of psychopathological symptoms was assessed using the PANSS and HDRS-21 scales. The activity of infl ammatory markers leukocyte elastase (LE) and α1-proteinase inhibitor (α1-PI) was determined in patients' blood. Absolute neutrophil and lymphocyte contents and their ratio (the neutrophil:lymphocyte index) were also evaluated. Standard values for indicators from healthy donors corresponding to patients in terms of age and sex were used as control values. Results. Endogenous psychosis developing at longer intervals after coronavirus infection (group 2) was found to be associated with "typical" infl ammatory reactions, with increases in the activity of acute-phase proteins (α1-PI: 43.0 (35.6-49.7) IU/ml, p = 0.001) and neutrophil degranulation activity (LE -254.8 (238.0-271.0) nmol/min•ml, p < 0.001), which was associated with the development of depressive-delusional states with dominance of manifestations of positive affectivity (anxiety, melancholy) and the extended nature of delusional disorders, which were mostly incongruent to affect. Conversely, development of endogenous psychosis during the fi rst two months after COVID-19 (group 1) was characterized by a spectrum of infl ammatory biomarkers with a decrease in neutrophil count ((2.6 ± 0.9)•10 9 /liter, p < 0.05) and low LE activity (196 (172-209.4) nmol/min•ml, p < 0.001). This immunological profi le was associated with predominance of manifestations of negative affectivity (apathy, asthenia, adynamia) in the structure of depressive-delusional states and the relatively undeveloped nature of delusional disorders, which were predominantly congruent to affect. Conclusions. The clinical and biological correlates found here presumptively indicate that experience of COVID-19 infection has a modulatory effect on neuroinfl ammation and the structure of endogenous psychosis.

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supporting

confidence: 88%

supporting

confidence: 43%

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Clinical-Immunological Correlates in Post-COVID-19 Endogenous Psychoses

Zozulya

Сизов

Олейчик

et al. 2023

Neurosci Behav Physi

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“…Research by Kliushnik, T. et al indicated that antibodies to MBP may be related to the diagnosis of schizophrenia [ 21 , 22 ], and associated with the severity of clinical symptoms [ 23 ]. The different dynamics of immune markers, including autoantibodies to MBP, correspond to different features of clinical remission after first-episode psychosis in young patients [ 24 ]. Among antigen-binding antibodies there are antibodies that can catalytically modify the antigen.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Antipsychotic Treatment on the Activity of Abzymes Targeting Myelin and Levels of Inflammation Markers in Patients with Schizophrenia

et al. 2023

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Catalytic antibodies, or abzymes, are capable of not only binding but also hydrolyzing various proteins. Previously, an increase in the level of myelin basic protein (MBP)-hydrolyzing activity of antibodies was shown in patients with a number of neurological and mental disorders, including schizophrenia. Furthermore, antipsychotic therapy is known to induce a change in cytokine levels in patients with schizophrenia, which affects regulation of the immune response and inflammatory status. This study investigated the influence of typical and atypical antipsychotics on catalytic antibody activity and the 10 major pro- and anti-inflammatory serum cytokine levels. The study included 40 patients with schizophrenia: 15 treated with first-generation antipsychotics and 25 treated with atypical antipsychotics for 6 weeks. It was found that treatment with atypical antipsychotics changed the levels of some pro-inflammatory cytokines. Antipsychotic therapy also caused a significant decrease in MBP-hydrolyzing activity in patients with schizophrenia (p = 0.0002), and associations of catalytic activity with interleukins were observed.

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Dynamics of Postpsychotic Depression in Adolescence

Каледа

Tikhonov

2023

Neurosci Behav Physi

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Immune-inflammatory markers in remission after a first-episode psychosis in young patients

Cited by 12 publications

References 14 publications

Clinical-Immunological Correlates in Post-COVID-19 Endogenous Psychoses

Clinical-Immunological Correlates in Post-COVID-19 Endogenous Psychoses

The Influence of Antipsychotic Treatment on the Activity of Abzymes Targeting Myelin and Levels of Inflammation Markers in Patients with Schizophrenia

Dynamics of Postpsychotic Depression in Adolescence

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