Immune-inflammatory pathways and clinical changes in fibromyalgia patients treated with Mindfulness-Based Stress Reduction (MBSR): A randomized, controlled clinical trial

Andrés‐Rodríguez, Laura; Borrás, Xavier; Feliu‐Soler, Albert; Pérez‐Aranda, Adrián; Rozadilla-Sacanell, Antoni; Montero-Marín, Jesús; Maes, Michaël; Luciano, Juan V.

doi:10.1016/j.bbi.2019.02.030

Cited by 62 publications

(67 citation statements)

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“…The regulation of burnout levels has been associated with adherence to mindfulness training and with perseverance, which are considered to be complementary forces (Sallon et al, ). Thus, studies have highlighted the long‐term beneficial effects that these resources have produced in individuals suffering from pathologies such as fibromyalgia (Andrés‐Rodríguez et al, ), cancer (Zhang, Zhao, & Zheng, ), mental disorders (Hedman‐Lagerlöf, Hedman‐Lagerlöf, & Öst, ; Rupp, Jürgens, Doebler andor, & Buhlmann, ), stress (Gawrysiak et al, ) and insomnia (Wang et al, ).…”

Section: Discussionmentioning

confidence: 99%

The effect of mindfulness training on burnout syndrome in nursing: A systematic review and meta‐analysis

Suleiman‐Martos

Gómez‐Urquiza

Aguayo‐Estremera

et al. 2020

Journal of Advanced Nursing

146

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Aim To analyse the effect of mindfulness training on levels of burnout among nurses. Background Burnout syndrome is a common occupational hazard for nursing staff. Mindfulness training has been proposed as a valid intervention for burnout. Design Systematic review and meta‐analysis. Data sources The CINAHL, LILACS, Medline, ProQuest, PsycINFO, Scielo and Scopus databases were consulted, using the search equation ‘Nurs * AND burnout AND mindfulness’. There was no restriction on the year of publication. Review methods Papers were selected for analysis in accordance with the PRISMA guidelines. The meta‐analysis was carried out using Review Manager 5.3 software. Results The sample was of 17 articles including 632 nurses. Mindfulness training reduces levels of burnout, producing lower scores for emotional exhaustion and depersonalization and higher for personal accomplishment. The differences in the means were 1.32 (95% CI: −9.41–6.78), 1.91 (95% CI: −4.50–0.68) and 2.12 (95% CI: −9.91–14.14), respectively, between the intervention and control groups. Conclusion Mindfulness training reduces the emotional burden and hence levels of burnout, among nurses. However, further randomized clinical trials are required.

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Section: Discussionmentioning

confidence: 99%

The effect of mindfulness training on burnout syndrome in nursing: A systematic review and meta‐analysis

Suleiman‐Martos

Gómez‐Urquiza

Aguayo‐Estremera

et al. 2020

Journal of Advanced Nursing

146

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“…51 Nevertheless, there are also studies reporting lowered levels of CXCL8 in patients with fibromyalgia. 52 There is increasing evidence that chemokines are involved in the central regulation of feeding behavior, catabolic processes and weight maintenance. 53,54,55 Moreover, chemokines exert their actions on hypothalamic nuclei, which control feeding behaviors and body weight.…”

Section: Discussionmentioning

confidence: 99%

The Uterine-Chemokine-Brain Axis: Menstrual Cycle-Associated Symptoms (MCAS) are in Part Mediated by CCL2, CCL5, CCL11, CXCL8 and CXCL10

Roomruangwong

Sirivichayakul

Carvalho

et al. 2019

Preprint

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Objective: To examine associations between chemokines and menstrual cycle associated symptoms (MCAS). Methods: Forty-one women completed the Daily Record of Severity of Problems (DRSP) rating scale during 28 consecutive days of the menstrual cycle. MCAS is diagnosed when the total daily DRSP score during the menstrual cycle is > 0.666 percentile. We assayed plasma CCL2, CCL5, CCL11, CXCL8, CXCL10, EGF, IGF-1, and PAI-1 at days 7, 14, 21 and 28 of the menstrual cycle. Results: CCL2, CCL5, CCL11 and EGF are significantly higher in women with MCAS than in those without. Increased CCL2, CXCL10, CXCL8, CCL11 and CCL5 levels are significantly associated with DRSP scores while CCL2 is the most significant predictor explaining 39.6% of the variance. The sum of the neurotoxic chemokines CCL2, CCL11 and CCL5 is significantly associated with the DRSP score and depression, physiosomatic, breast-craving and anxiety symptoms. The impact of chemokines on MCAS symptoms may differ between consecutive weeks of the menstrual cycle with CCL2 being the most important predictor of increased DRSP levels during the first two weeks, and CXCL10 or a combination of CCL2, CCL11 and CCL5 being the best predictors during week 3 and 4, respectively. Discussion: The novel case definition “MCAS” is externally validated by increased levels of uterus-associated chemokines and EGF. Those chemokines are involved in MCAS and are regulated by sex hormones and modulate endometrium functions and brain neuro-immune responses, which may underpin MCAS symptoms. As such, uterine-related chemokines may link the uterus with brain functions via a putative uterine-chemokine-brain axis.

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“…In this scenario, non-pharmacological treatments based on psychoeducation, physical exercise, mindfulness, and cognitive-behavior therapy (CBT) have proven their effectiveness for improving mental health, increasing physical function, decreasing symptoms, and strengthening the acceptance of FM, obtaining small to medium effect sizes [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Furthermore, multicomponent treatments integrating some of these practices have been considered the gold-standard for managing FM [ 6 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Meta-analyses have provided evidence that mindfulness-based interventions (MBIs) are especially effective for improving quality of life and pain compared to usual care and even some active control treatments [ 11 , 12 ]. In addition, MBIs have been shown to be effective in modifying FM-related immune-inflammatory markers [ 13 ]. Specifically, amygdala and insula retraining (AIR), a mind–body approach, has preliminarily demonstrated improvements in physical health, energy, pain, distress, and fatigue in patients with FM and chronic fatigue syndrome (CFS) [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, both structures seem to present morphological [ 22 ] and functional [ 23 , 24 ] abnormalities in patients with FM correlating with pain intensity and other FM symptoms [ 25 ]. At the same time, there is mounting evidence that immune-inflammatory abnormalities in patients with FM (e.g., increased levels of pro-inflammatory cytokine IL-6, decreased levels of anti-inflammatory IL-10) may also contribute to the abnormal processing of pain signals (both the CNS and peripheral nervous system [PNS]), promoting and maintaining FM symptomatology [ 13 ]. Besides, increased levels of brain-derived neurotrophic factor (BDNF) have also been found in FM, with some authors suggesting its potential implication in pain chronification [ 26 ] as it plays a key role in a variety of neuroplasticity processes, including pain modulation, pain transduction, nociception, and hyperalgesia [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Mindfulness-Based Program Plus Amygdala and Insula Retraining (MAIR) for the Treatment of Women with Fibromyalgia: A Pilot Randomized Controlled Trial

Sanabria‐Mazo

Montero-Marín

Feliu‐Soler

et al. 2020

JCM

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The lack of highly effective treatments for fibromyalgia (FM) represents a great challenge for public health. The objective of this parallel, pilot randomized controlled trial (RCT) was two-fold: (1) to analyze the clinical effects of mindfulness plus amygdala and insula retraining (MAIR) compared to a structurally equivalent active control group of relaxation therapy (RT) in the treatment of FM; and (2) to evaluate its impact on immune-inflammatory markers and brain-derived neurotrophic factor (BDNF) in serum. A total of 41 FM patients were randomized into two study arms: MAIR (intervention group) and RT (active control group), both as add-ons of treatment as usual. MAIR demonstrated significantly greater reductions in functional impairment, anxiety, and depression, as well as higher improvements in mindfulness, and self-compassion at post-treatment and follow-up, with moderate to large effect sizes. Significant decreases in pain catastrophizing and psychological inflexibility and improvements in clinical severity and health-related quality of life were found at follow-up, but not at post-treatment, showing large effect sizes. The number needed to treat was three based on the criteria of ≥50% Fibromyalgia Impact Questionnaire (FIQ) reduction post-treatment. Compared to RT, the MAIR showed significant decreases in BDNF. No effect of MAIR was observed in immune-inflammatory biomarkers (i.e., TNF-α, IL-6, IL-10, and hs-CRP). In conclusion, these results suggest that MAIR, as an adjuvant of treatment-as-usual (TAU), appears to be effective for the management of FM symptoms and for reducing BDNF levels in serum.

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Immune-inflammatory pathways and clinical changes in fibromyalgia patients treated with Mindfulness-Based Stress Reduction (MBSR): A randomized, controlled clinical trial

Cited by 62 publications

References 63 publications

The effect of mindfulness training on burnout syndrome in nursing: A systematic review and meta‐analysis

The effect of mindfulness training on burnout syndrome in nursing: A systematic review and meta‐analysis

The Uterine-Chemokine-Brain Axis: Menstrual Cycle-Associated Symptoms (MCAS) are in Part Mediated by CCL2, CCL5, CCL11, CXCL8 and CXCL10

Mindfulness-Based Program Plus Amygdala and Insula Retraining (MAIR) for the Treatment of Women with Fibromyalgia: A Pilot Randomized Controlled Trial

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