Immune-instructive materials as new tools for immunotherapy

Fisher, Len; Kämmerling, Lisa; Alexander, Morgan R.; Ghaemmaghami, Amir M.

doi:10.1016/j.copbio.2021.11.005

Cited by 13 publications

(13 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…[123] Macrophages play an essential role in the inflammatory and tissue repair process and the ability to modulate changes in their phenotype facilitates the design of immune-instructive materials. [124] Although the extent of biomimicry and resolution, that is required to regenerate a fully functional tissue, remains unknown, a balance between architectural guidance through scaffolds and self-assembly of cellular building blocks is desirable. Depending on the target tissue's complexity of matrix components and its self-healing potential, cells can self-produce and self-organize the matrix.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

The Synergy of Biomimetic Design Strategies for Tissue Constructs

Haag

Dalton

Bloemen

2022

Adv Funct Materials

View full text Add to dashboard Cite

The regeneration and repair of complex structures, interfaces, and mechanical properties present in natural tissues remains a challenge. To move beyond simplified tissue engineered constructs, nature is a source of inspiration for complex, hierarchical scaffold designs. Recent advances in additive manufacturing allow for increasingly complex fabrication of architectures that better mimic the multiscale structure-function relationship found in natural tissues. In this review, scaffold-based and scaffold-free approaches and the synergistic use of fabrication technologies (two things make a third) to produce more biomimetic implants are described. Recent advanced scaffold designs such as auxetic mechanical metamaterials and induced fibrillar alignment are highlighted. Next, the pre-programmed assembly of spheroids, tissue strands, and other modular building blocks without the need for permanent exogenous scaffold support are discussed. Furthermore, the application of hybridized manufacturing processes to fabricate hierarchical functional constructs is outlined for the osteochondral unit, vascular grafts, and peripheral nerves.

show abstract

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

The Synergy of Biomimetic Design Strategies for Tissue Constructs

Haag

Dalton

Bloemen

2022

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…Despite the clinical success in cancer immunotherapy, there are still challenges hindering their wide applications, such as standardized preparation, antigen pulsing, and suitable administration route. 47 2.1.5 Regulatory T cell therapy. Regulatory T cells (Treg cells) are a small portion of immune cells responsible for maintaining homeostasis by suppressing immune overactivation.…”

Section: Cell Therapiesmentioning

confidence: 99%

“…46 Like other adoptive therapies, DC-based therapeutics also suffer from difficulties in expansion, insufficient targeting abilities, and poor cell persistence, which may be solved by integrating biomaterials into DCs to improve their viability, proliferation, and functionality. 47 Recently, many researchers have attempted to employ various biomaterials, such as scaffolds, polymeric particles, or hydrogels, to promote the viabilities and abilities of DCs. Srinivasan et al reported a multicomponent immunomodulatory scaffold prepared by incorporating glutaraldehyde-crosslinked gelatin microparticles into an agarose matrix.…”

Section: Biomaterial-assisted Cell Therapiesmentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in biomaterial-assisted cell therapy

Chen

Pal

2022

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Materials Design Innovations in Optimizing Cellular Behavior on Melt Electrowritten (MEW) Scaffolds

Devlin,

Allenby,

Ren

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

The field of melt electrowriting (MEW) has seen significant progress, bringing innovative advancements to the fabrication of biomaterial scaffolds, and creating new possibilities for applications in tissue engineering and beyond. Multidisciplinary collaboration across materials science, computational modeling, AI, bioprinting, microfluidics, and dynamic culture systems offers promising new opportunities to gain deeper insights into complex biological systems. As the focus shifts towards personalized medicine and reduced reliance on animal models, the multidisciplinary approach becomes indispensable. This review provides a concise overview of current strategies and innovations in controlling and optimizing cellular responses to MEW scaffolds, highlighting the potential of scaffold material, MEW architecture, and computational modeling tools to accelerate the development of efficient biomimetic systems. Innovations in material science and the incorporation of biologics into MEW scaffolds have shown great potential in adding biomimetic complexity to engineered biological systems. These techniques pave the way for exciting possibilities for tissue modeling and regeneration, personalized drug screening, and cell therapies.

show abstract

Immune-instructive materials as new tools for immunotherapy

Cited by 13 publications

References 56 publications

The Synergy of Biomimetic Design Strategies for Tissue Constructs

The Synergy of Biomimetic Design Strategies for Tissue Constructs

Recent advances in biomaterial-assisted cell therapy

Materials Design Innovations in Optimizing Cellular Behavior on Melt Electrowritten (MEW) Scaffolds

Contact Info

Product

Resources

About