Immune-mediated adverse effects of biologicals used in the treatment of rheumatic diseases

Borchers, Andrea T.; Leibushor, Naama; Cheema, Gurtej S.; Naguwa, Stanley M.; Gershwin, M. Eric

doi:10.1016/j.jaut.2011.08.002

Cited by 44 publications

(28 citation statements)

References 211 publications

(229 reference statements)

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“…Like IIS cases, the clinical picture of this type of sarcoidosis included predominantly pulmonary and cutaneous features. Pulmonary involvement was found in 74% patients, and cutaneous involvement in 29% [76].…”

Section: Anti-tnf-associated Sarcoidosismentioning

confidence: 99%

“…The time between initiation of therapy and the onset of signs and symptoms of sarcoidosis in highly variable, with a median duration of approximately 21 months, a range < 1 month to 4 years [76]. Like IIS cases, the clinical picture of this type of sarcoidosis included predominantly pulmonary and cutaneous features.…”

Section: Anti-tnf-associated Sarcoidosismentioning

confidence: 99%

“…The underlying diseases in cases of anti-TNF-associated sarcoidosis include RA, psoriasis/ psoriatic arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, and Crohn's disease [19,76]. The time between initiation of therapy and the onset of signs and symptoms of sarcoidosis in highly variable, with a median duration of approximately 21 months, a range < 1 month to 4 years [76].…”

Section: Anti-tnf-associated Sarcoidosismentioning

confidence: 99%

“…The prognosis of sarcoidosis occurring during TNF blockade is generally favorable since almost all patients showed clinical recovery after anti-TNF discontinuation with or without corticosteroid therapy [75,76]. Therapy with TNF antagonist was discontinued, resulting in spontaneous resolution in some patients, whereas symptoms persisted in others, necessitating corticosteroid treatment (40-50%) [74,75].…”

Section: Anti-tnf-associated Sarcoidosismentioning

confidence: 99%

See 3 more Smart Citations

The Role of Type I IFN and TNF-α in the Pathogenesis of Sarcoidosis

Akahoshi¹

2013

Sarcoidosis

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Section: Anti-tnf-associated Sarcoidosismentioning

confidence: 99%

Section: Anti-tnf-associated Sarcoidosismentioning

confidence: 99%

Section: Anti-tnf-associated Sarcoidosismentioning

confidence: 99%

Section: Anti-tnf-associated Sarcoidosismentioning

confidence: 99%

See 2 more Smart Citations

The Role of Type I IFN and TNF-α in the Pathogenesis of Sarcoidosis

Akahoshi¹

2013

Sarcoidosis

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“…Anti-TNF-α agents are proven efficacious therapies for rheumatoid arthritis, ankylosing spondylitis, and inflammatory bowel disease (Lin et al, 2008;Karampetsou et al, 2010). Anti-TNF-α has the potential to reduce the risk of developing lymphoma, and is an efficacious and relatively safe treatment that has rarely been associated with serious side effects (Hyrich et al, 2004;Franklin et al, 2005;Borchers et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Expression of recombinant human anti-TNF-α scFv-Fc in Arabidopsis thaliana seeds

Yao¹,

Ai²,

Dong³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Recombinant human anti-tumor necrosis factor (TNF)-α scFv-Fc was expressed in TKO mutant Arabidopsis thaliana seeds using plant-specific codons. Immunoblotting using a human IgG1 antibody detected the expression of anti-TNF-α proteins in plants. Results from qRT-PCR analysis demonstrated that the time of harvest significantly affected the protein yield and quality. Our results indicate that the Phaseolus vulgaris β-phaseolin promoter directed anti-TNF-α scFvFc expression in A. thaliana seeds, with a maximum yield obtained at 20-days of development. Although the yield of anti-TNF-α scFvFc protein was not very high, accumulation of recombinant proteins in seeds is an attractive and simple method that can be used to purify biologically active anti-TNF-α scFv-Fc.

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Liver Immunology

Bogdanos

Gao

Gershwin

2013

Comprehensive Physiology

Self Cite

181

130

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The liver is the largest organ in the body and is generally regarded by non-immunologists as not having lymphoid function. However, such is far from accurate. This review highlights the importance of the liver as a lymphoid organ. Firstly, we discuss experimental data surrounding the role of liver as a lymphoid organ. The liver facilitates a tolerance rather than immunoreactivity, which protects the host from antigenic overload of dietary components and drugs derived from the gut and is also instrumental to fetal immune tolerance. Loss of liver tolerance leads to autoaggressive phenomena which if are not controlled by regulatory lymphoid populations may lead to the induction of autoimmune liver diseases. Liver-related lymphoid subpopulations also act as critical antigen-presenting cells. The study of the immunological properties of liver and delineation of the microenvironment of the intrahepatic milieu in normal and diseased livers provides a platform to understand the hierarchy of a series of detrimental events which lead to immune-mediated destruction of the liver and the rejection of liver allografts. The majority of emphasis within this review will be on the normal mononuclear cell composition of the liver. However, within this context, we will discus select, but not all, immune mediated liver disease and attempt to place these data in the context of human autoimmunity.

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Immune-mediated adverse effects of biologicals used in the treatment of rheumatic diseases

Cited by 44 publications

References 211 publications

The Role of Type I IFN and TNF-α in the Pathogenesis of Sarcoidosis

The Role of Type I IFN and TNF-α in the Pathogenesis of Sarcoidosis

Expression of recombinant human anti-TNF-α scFv-Fc in Arabidopsis thaliana seeds

Liver Immunology

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