Immune-mediated audiovestibular disorders in the paediatric population: A review

Ågrup, Charlotte

doi:10.1080/14992020802282268

Cited by 19 publications

(12 citation statements)

References 49 publications

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“…The prevalence of autoimmune hearing loss increases with age and, in the pediatric population, is highest in late adolescence. 36 Autoimmune labyrinthitis appears similar to infectious forms of labyrinthitis on MR imaging and will demonstrate intense labyrinthine enhancement acutely on postcontrast T1WIs (Fig 7). 28 The imaging abnormalities often resolve with steroid treatment but may occasionally progress to fibrosing or ossifying labyrinthitis.…”

Section: Autoimmune Labyrinthitismentioning

confidence: 99%

Pediatric Sensorineural Hearing Loss, Part 2: Syndromic and Acquired Causes

Huang¹,

Zdanski²,

Castillo³

2011

AJNR Am J Neuroradiol

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SUMMARY:This article is the second in a 2-part series reviewing neuroimaging in childhood SNHL. Previously, we discussed the clinical work-up of children with hearing impairment, the classification of inner ear malformations, and congenital nonsyndromic causes of hearing loss. Here, we review and illustrate the most common syndromic hereditary and acquired causes of childhood SNHL, with an emphasis on entities that demonstrate inner ear abnormalities on cross-sectional imaging. Syndromes discussed include BOR syndrome, CHARGE syndrome, Pendred syndrome, Waardenburg syndrome, and X-linked hearing loss with stapes gusher. We conclude the article with a review of acquired causes of childhood SNHL, including infections, trauma, and neoplasms.ABBREVIATIONS: BOR ϭ branchio-oto-renal; CISS ϭ constructive interference in steady state; IAC ϭ internal auditory canal; NF-2 ϭ neurofibromatosis type II; SCC ϭ semicircular canal; SNHL ϭ sensorineural hearing loss; T1WI ϭ T1-weighted image; T2WI ϭ T2-weighted image T he estimated prevalence of SNHL in patients younger than 18 years of age is 6 per 1000, 1 making it one of the leading causes of childhood disability and a common reason for otolaryngology referrals. Cross-sectional imaging is now routinely performed in these patients because it provides important information about potential etiologies for hearing loss, defines the anatomy of the temporal bone and the central auditory pathway, and identifies additional intracranial abnormalities that may require further work-up. In the first part of our series, we reviewed some of the practical aspects related to imaging children with SNHL, including epidemiology, clinical work-up, and choices of imaging technique; we also discussed the classification of congenital inner ear malformations and congenital nonsyndromic causes of SNHL. In this article, we continue our discussion of neuroimaging for childhood SNHL, focusing on several of the most common syndromic hereditary forms of SNHL as well as acquired causes of hearing loss.

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Section: Autoimmune Labyrinthitismentioning

confidence: 99%

Pediatric Sensorineural Hearing Loss, Part 2: Syndromic and Acquired Causes

Huang¹,

Zdanski²,

Castillo³

2011

AJNR Am J Neuroradiol

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“…Different theories have been proposed to explain the etiology. These include, for example, bacterial, viral, and protozoan infections, vascular occlusion, mechanisms associated with the immune system, ototoxicity drugs (salicylates, aminoglycosides) and traumatic, vascular, neoplastic, and metabolic conditions [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume: Is It a Predictive Parameter in The Diagnosis of Sudden Sensorineural Hearing Loss?

Karli

Alaçam

Ünal

et al. 2013

Indian J Otolaryngol Head Neck Surg

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The mean platelet volume (MPV) is associated with increased platelet reactivity and increased atherothrombosis. High MPV values are a risk factor for thrombotic vascular diseases. Our aim was to investigate whether a relationship exists between sudden sensorineural hearing loss (SSHL) and a high MPV value. The records of 46 patients who were admitted to the ENT (ear nose throat) ward for SSHL and received medical treatment and 46 patients in a control group were retrospectively screened. The correlation among the levels of the MPV, the number of platelets, and SSHL were evaluated in the two groups. The ages, genders, and the platelet count values of the patients showed a normal distribution in both groups. No significant difference was found for the MPV values between the groups. The MPV is not a predictive parameter in the diagnosis of SSHL.

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“…[12][13][14] Second, comparison with a normal control group is needed to confirm the correlation between sudden SNHL and autoantibody expression. First, we used systemic antibodies rather than those specific to the inner ear.…”

Section: Resultsmentioning

confidence: 99%