2022
DOI: 10.2196/29892
|View full text |Cite
|
Sign up to set email alerts
|

Immune-Mediated Mechanisms in Patients Testing Positive for SARS-CoV-2: Protocol for a Multianalysis Study

Abstract: Background The novel coronavirus has a high mortality rate (over 1% for patients older than 50 years). This can only be partially ascribed to other comorbidities. A possible explanation is a factor that assures a prompt response to SARS-CoV-2 in younger people, independent from the novelty of the virus itself. A factor is believed to stimulate the immune system and provide immunity against more antigens. The only external stimulation received by healthy people is vaccination (eg, the diphtheria, te… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2022
2022
2022
2022

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 34 publications
0
1
0
Order By: Relevance
“…Moreover, while the number of naïve T cells may be sufficient to sustain the vaccination effects, even with a new antigen, it could be that defects in the innate immune system may hamper the effective immune response to the vaccine. However, recent experimental data supporting the notion that inflammaging may be an adaptive process in conjunction with what is called "trained innate immunity" highlights the possibility that the innate immune system could also effectively prime the adaptive immune response in older individuals [80,[145][146][147]. These new discoveries suggest that better cooperation among the innate and adaptive immune response is possible in older subjects.…”
Section: New Evidence From Experimental Data On Vaccine Response In O...mentioning
confidence: 99%
“…Moreover, while the number of naïve T cells may be sufficient to sustain the vaccination effects, even with a new antigen, it could be that defects in the innate immune system may hamper the effective immune response to the vaccine. However, recent experimental data supporting the notion that inflammaging may be an adaptive process in conjunction with what is called "trained innate immunity" highlights the possibility that the innate immune system could also effectively prime the adaptive immune response in older individuals [80,[145][146][147]. These new discoveries suggest that better cooperation among the innate and adaptive immune response is possible in older subjects.…”
Section: New Evidence From Experimental Data On Vaccine Response In O...mentioning
confidence: 99%