Immune-mediated necrotising myopathy linked to statin use

Statinassoziierte Muskelsymptome und Statinmyopathie

“…Im Muskel-MRT kann ein Muskelödem (▶ Abb. 2) oder auch nur eine Muskelatrophie mit bindegewebigem Ersatz zu finden sein [64].…”

Statin-associated immune-mediated necrotizing myopathy: a retrospective analysis of individual case safety reports from VigiBase

“…Patients with IMNM experience myalgia with symmetrical and proximal weakness. Laboratory tests may reveal substantially elevated (>2000 U/L in approximately 90% of cases; normal range <171 U/L) creatine kinase (CK) concentrations [5,8]. Myopathy might be progressive, even after the discontinuation of statin therapy [5], and represents the main clinical feature which leads to suspicion of an autoimmune myopathy.…”