Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading

Apinun, Jirun; Sengprasert, Panjana; Yuktanandana, Pongsak; Ngarmukos, Srihatach; Tanavalee, Aree; Reantragoon, Rangsima

doi:10.1155/2016/9525724

Cited by 31 publications

(32 citation statements)

References 39 publications

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“…In a report by Penatti et al (2017), they have reported a higher CD4/CD8 T cell ratio in the peripheral blood of patients with OA as compared to healthy donors; however, the CD8 T cell frequencies seemed to be higher in the SF of patients with OA as compared to the peripheral blood which corroborates with our results as well . Similar results were reported in another study where an increased proportion of CD8+ T cells within the synovial tissue was found as compared to proportions in the circulating peripheral blood . We also observed a decreased infiltration of CD8+ T cells as the disease progressed to advanced stage.…”

Section: Discussionsupporting

confidence: 92%

Chronic inflammation during osteoarthritis is associated with an increased expression of CD161 during advanced stage

et al. 2019

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Increasing evidence suggests a role of inflammation during the pathogenesis of osteoarthritis (OA). The local and systemic inflammation was studied in 33 patients of different KL grades, grade2 (n = 11), grade3 (n = 6) and grade4 (n = 16). The levels of cytokines, adipokines and matrix metalloproteinases (MMPs) were measured in serum and synovial fluid (SF) by flow cytometry and ELISA, respectively. The frequency of T cells and CD161 expression was measured by flow cytometry. The levels of IL‐1β, IL‐6 and IL‐10 were significantly higher in sera and SF of patients with OA as compared to healthy control's serum. Higher levels of MMP9 and leptin and lower levels of adiponectin were observed in SF as compared to serum. The MMP9 in SF and MMP13 levels in serum and SF decreased in KL grade 4 cases. In these patients, higher levels of leptin and lower levels of adiponectin were observed in SF versus patients of lower grades. There was increased infiltration of CD8+ T cells in SF of OA cases with decreased frequency in grade 4 cases. The expression of CD161 on T cells was significantly higher in SF than peripheral blood with significant upregulation in grade 4 patients. The CD161 expression had significant positive correlation with IL‐17 in the serum of patients. The ROC curves of CD161 expression significantly distinguished grade 2 and grade 4 patients. Collectively, an elevated CD161 expression on T cells in circulation and synovial compartment clearly distinguished lower and higher grade patients warranting studies to assess its role as a contributing factor towards OA progression.

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Section: Discussionsupporting

confidence: 92%

Chronic inflammation during osteoarthritis is associated with an increased expression of CD161 during advanced stage

et al. 2019

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“…Of all these pathological manifestations, fibrosis may be the most typical characteristic of the IFP in OA patients [1]. Histological analyses indicate that the extent of fibrosis in the IFP was higher than that in the SAT [24]. Histological changes, such as IFP fibrosis, may not only be involved in molecular OA processes by changing cytokines production [1,23], but they may also alter the IFP biomechanical properties, thus modifying its ability to absorb gravitational forces exerting on the knee joint, and promoting and perpetuating joint damage [1].…”

Section: Involvement Of Ifp In Koa Pathogenesismentioning

confidence: 99%

“…The immune response is activated following the damage of cartilage. The role of immune responses has been demonstrated in the pathogenesis of OA [24], during which both innate and adaptative immunity may play important roles [36].…”

Section: Immunophenotype Of Immune Cellsmentioning

confidence: 99%

Infrapatellar Fat Pad and Knee Osteoarthritis

et al. 2020

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Osteoarthritis is the most prevalent arthritis typically characterized by degradation of cartilage. However, its pathogenesis is not fully understood. Currently, osteoarthritis is best considered a disease of the whole "joint organ". Infrapatellar fat pad (IFP), an adipose tissue near synovium, is now attaching importance to researchers for its inflammatory phenotype. In this narrative review, a large body of evidence has been gathered for the involvement of IFP in the development of knee osteoarthritis. Additionally, the underlying mechanisms of how IFP can be involved in this process have been proposed. However, further investigations are needed to better understand its precise role in this process and its underlying mechanism, and beyond that, to develop new strategies to slow down the degenerative process and explore an effective and timely diagnosis of the disease.

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“…Alteration of both conventional and nonconventional Th subsets suggests a role of T cells in OA onset and progression [ 118 ]. A recent paper indicated that in infrapatellar fat pad there is an increase of infiltrating CD8+ T cells that correlates with the radiological score [ 119 ]. B cells, plasma cells, natural killer cells, dendritic cells, and granulocytes are also occasionally present.…”

Section: Low-grade Inflammation In Oamentioning

confidence: 99%

Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low‐Grade Inflammation in Osteoarthritis

Minguzzi

Cetrullo

D’Adamo

et al. 2018

Oxidative Medicine and Cellular Longevity

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The prevalence of Osteoarthritis (OA) is increasing because of the progressive aging and unhealthy lifestyle. These risk factors trigger OA by removing constraints that keep the tightly regulated low turnover of the extracellular matrix (ECM) of articular cartilage, the correct chondrocyte phenotype, and the functionality of major homeostatic mechanisms, such as mitophagy, that allows for the clearance of dysfunctional mitochondria, preventing increased production of reactive oxygen species, oxidative stress, and senescence. After OA onset, the presence of ECM degradation products is perceived as a “danger” signal by the chondrocytes and the synovial macrophages that release alarmins with autocrine/paracrine effects on the same cells. Alarmins trigger innate immunity in the joint, with important systemic crosstalks that explain the beneficial effects of dietary interventions and improved lifestyle. Alarmins also boost low-grade inflammation: the release of inflammatory molecules and chemokines sustained by continuous triggering of NF-κB within an altered cellular setting that allows its higher transcriptional activity. Chemokines exert pleiotropic functions in OA, including the recruitment of inflammatory cells and the induction of ECM remodeling. Some chemokines have been successfully targeted to attenuate structural damage or pain in OA animal models. This represents a promising strategy for the future management of human OA.

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Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading

Cited by 31 publications

References 39 publications

Chronic inflammation during osteoarthritis is associated with an increased expression of CD161 during advanced stage

Chronic inflammation during osteoarthritis is associated with an increased expression of CD161 during advanced stage

Infrapatellar Fat Pad and Knee Osteoarthritis

Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low‐Grade Inflammation in Osteoarthritis

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