Immune Microenvironment Signatures as Biomarkers to Predict Early Recurrence of Stage Ia-b Lung Cancer

Wang, Qiang; Zhou, Danting; Wu, Fang; Liang, Qingchun; He, Qiongzhi; Peng, Muyun; Yao, Tianyu; Hu, Yan; Qian, Banglun; Tang, Jingqun; Wang, Xiang; Li, Wenliang; Yu, Fenglei; Chen, Chen

doi:10.3389/fonc.2021.680287

Cited by 20 publications

(18 citation statements)

References 54 publications

(63 reference statements)

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“…In contrast, the density of memory B cells was higher in the control group. Further investigation revealed that Treg cells were substantially associated with lung cancer recurrence and that SLFN13 was one of the immune-related predictors of lung cancer recurrence ( 49 ). This research on SLFN family members promoting cancer appears to be related to another function of the family; i.e., they can regulate immune function and T cells to maintain a resting state ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

Schlafen family is a prognostic biomarker and corresponds with immune infiltration in gastric cancer

Chen

Liang

et al. 2022

Front. Immunol.

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The Schlafen (SLFN) gene family plays an important role in immune cell differentiation and immune regulation. Previous studies have found that the increased SLFN5 expression in patients with intestinal metaplasia correlates with gastric cancer (GC) progression. However, no investigation has been conducted on the SLFN family in GC. Therefore, we systematically explore the expression and prognostic value of SLFN family members in patients with GC, elucidating their possible biological function and its correlation with tumor immune cells infiltration. TCGA database results indicated that the SLFN5, SLFN11, SLFN12, SLFN12L, and SLFN13 expression was significantly higher in GC. The UALCAN and KM plotter databases indicated that enhanced the SLFN family expression was associated with lymph node metastasis, tumor stage, and tumor grade and predicted an adverse prognosis. cBioportal database revealed that the SLFN family had a high frequency of genetic alterations in GC (about 12%), including mutations and amplification. The GeneMANIA and STRING databases identified 20 interacting genes and 16 interacting proteins that act as potential targets of the SLFN family. SLFN5, SLFN11, SLFN12, SLFN12L, and SLFN14 may be implicated in the immunological response, according to Gene Set Enrichment Analysis (GSEA) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Additionally, Timer and TISIDB databases indicate that SLFN5, SLFN11, SLFN12, SLFN12L, and SLFN14 are involved in the immune response. Furthermore, Timer, TCGA, and TISIDB databases suggested that the SLFN5, SLFN11, SLFN12, SLFN12L, and SLFN14 expression in GC is highly linked with immune cell infiltration levels, immune checkpoint, and the many immune cell marker sets expression. We isolated three samples of peripheral blood mononuclear cell (PBMC) and activated T cells; the results showed the expression of SLFN family members decreased significantly when T cell active. In conclusion, the SLFN family of proteins may act as a prognostic indicator of GC and is associated with immune cell infiltration and immune checkpoint expression in GC. Additionally, it may be involved in tumor immune evasion by regulating T cell activation.

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Section: Discussionmentioning

confidence: 99%

Schlafen family is a prognostic biomarker and corresponds with immune infiltration in gastric cancer

Chen

Liang

et al. 2022

Front. Immunol.

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“…A previous study has shown that TPRG1 was up-regulated in patients with inflammation-related diseases, and TPRG1 stimulated inflammatory responses [ 8 ]. Moreover, TPRG1 was considered as an immune-related gene, and correlated with tumor recurrence of stage Ia-b lung cancer [ 9 ]. Our results showed that the expression levels of TNF-α, IL-6, and IL-1β were enhanced in E. coli- induced cystitis rat, and knockdown of TPRG1 suppressed the inflammatory response in E. coli- induced cystitis rat through down-regulation of TNF-α, IL-6, and IL-1β.…”

Section: Discussionmentioning

confidence: 99%

“…TPRG1 was associated with inflammatory pathways and stimulates inflammatory responses [ 8 ]. TPRG1, as an immune-related gene, was correlated with tumor recurrence of stage Ia-b lung cancer [ 9 ]. Moreover, microarray analysis showed that TPRG1 was up-regulated in bladder mucosa isolated from cystitis glandularis patients [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

TPRG1 contributes to inflammation and cell proliferation of cystitis glandularis through regulating NF-кB/COX2/PGE2 axis

Hong¹,

Piao²,

Sun³

et al. 2022

Bosn J of Basic Med Sci

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Cystitis glandularis is characterized by chronic inflammation and hyperproliferation of bladder mucosa, and contributes to progression of bladder adenocarcinoma. TPRG1 (Tumor Protein P63 Regulated 1) is related to cellular inﬂammatory response, and dysregulation of TPRG1 in tumor tissues is associated with tumor early recurrence. The effect of TPRG1 on cystitis glandularis was investigated in this study. Firstly, bladder specimen were isolated from patients with cystitis glandularis and E. coli-induced cystitis rat. Expression of TPRG1 was found to be up-regulated in the bladder specimen. Moreover, adeno-associated virus (AAV)-mediated silence of TPRG1 was delivered into rat, and data from hematoxylin and eosin (H & E) staining showed that injection with AAV-shTPRG1 ameliorated E. coli-induced histological changes in bladder tissues of rats, and suppressed the inflammatory response. Secondly, TPRG1 was also increased in primary cystitis glandularis cells. Knockdown of TPRG1 decreased cell proliferation of primary cystitis glandularis cells, and suppressed the migration. Thirdly, cyclooxygenase-2 (COX-2) was up-regulated in the bladder specimen isolated from patients with cystitis glandularis and E. coli-induced cystitis rat. Injection with AAV-shTPRG1 reduced protein expression of COX-2, p65 and prostaglandin E2 (PGE2) in the bladder specimen. Lastly, interference of COX-2 attenuated TPRG1 over-expression-induced increase of cell proliferation and migration in the primary cystitis glandularis cells. In conclusion, TPRG1 promoted inflammation and cell proliferation of cystitis glandularis through activation of NF-кB/COX2/PGE2 axis.

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“…Emerging evidence suggests that the degree of immune cell infiltration correlates with prognosis in many types of cancer [ 3 ]. Immune-related genes (IRGs) have been reported to correlate with the progression, recurrence, and metastasis of lung cancer, suggesting that IRGs have acceptable prognostic values for disease outcomes [ 4 , 5 , 6 ]. Macrophages resident in the TME referred to as tumor-associated macrophages (TAMs), are the main immune cells found in the tumor microenvironment and can affect tumor progression and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Identifying M1-like macrophage related genes for prognosis prediction in lung adenocarcinoma based on a gene co-expression network

Wang

Yan

Yang

et al. 2023

Heliyon

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Immune Microenvironment Signatures as Biomarkers to Predict Early Recurrence of Stage Ia-b Lung Cancer

Cited by 20 publications

References 54 publications

Schlafen family is a prognostic biomarker and corresponds with immune infiltration in gastric cancer

Schlafen family is a prognostic biomarker and corresponds with immune infiltration in gastric cancer

TPRG1 contributes to inflammation and cell proliferation of cystitis glandularis through regulating NF-кB/COX2/PGE2 axis

Identifying M1-like macrophage related genes for prognosis prediction in lung adenocarcinoma based on a gene co-expression network

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