Immune modulation by mesenchymal stem cells

Jiang, Wei; Xu, Jianyong

doi:10.1111/cpr.12712

Cited by 452 publications

(366 citation statements)

References 245 publications

(563 reference statements)

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“…In the past decades, glucocorticoids, cyclophosphamide, calcineurin inhibitors (cyclosporine A and tacrolimus), mycophenolate mofetil, rituximab, tripterygium wilfordii, etc., have been used in the treatment of lupus nephritis and were also mentioned in the KDIGO 2012 guidelines [38]. MSC has been reported to be a good agent for the treatment of some autoimmune diseases in the past decades [3,39,40]. MSC treatment resulted in lower levels of ds-DNA, ANA, Scr, BUN, proteinuria, and renal sclerosis score, and MSC treatment could get a higher level of albumin.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of mesenchymal stem cells in animal models of lupus nephritis: a meta-analysis

Zhou

Liao

et al. 2020

Stem Cell Res Ther

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Background: Lupus nephritis is usually manifested by proteinuria, active urinary sediment, hypertension, and renal failure and is a serious complication with more than 50% occurrence in systemic lupus erythematosus patients. Mesenchymal stem cells (MSC) present remarkable immunomodulatory ability, and these cells are potential therapeutic agents for autoimmune disorders. In clinical trials, the effectiveness of MSC in the treatment of lupus nephritis is still controversial. A meta-analysis was performed to assess whether MSC can achieve good efficacy in the treatment of lupus nephritis in mice. Methods: A comprehensive literature search was performed in Cochrane Library, ISI Web of Science, PubMed, and EMBASE from inception to Oct 1, 2019. Two authors independently extracted the data, which were pooled and calculated using RevMan 5.3. Results: A total of 28 studies met the inclusion criteria. MSC treatment resulted in lower levels of ds-DNA (OR = −

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Section: Discussionmentioning

confidence: 99%

Efficacy of mesenchymal stem cells in animal models of lupus nephritis: a meta-analysis

Zhou

Liao

et al. 2020

Stem Cell Res Ther

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“…Mesenchymal stem cells (MSCs) are widely investigated because of their therapeutic potentials. In addition to their abilities to differentiate into multiple cell types, they could orchestrate the immune responses and modulate the tissue microenvironment, resulting in tissue regeneration [1][2][3][4][5][6]. Their supportive roles in regulating hematopoietic stem cell (HSC) homeostasis also highlight their therapeutic applications in HSC transplantations [7,8].…”

Section: Introductionmentioning

confidence: 99%

Chemical-defined medium supporting the expansion of human mesenchymal stem cells

Lian

Chen

et al. 2020

Stem Cell Res Ther

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Objectives: Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting the isolation and expansion of human MSCs has not been developed yet. Materials and methods: Here, we developed the full chemical-defined medium, NBVbe medium, via RNA sequencing, bioinformatic analysis, and growth factor screening. Results: The NBVbe medium contains N2B27 medium with the BSA (bovine serum albumin) replaced by the recombinant human albumin, bFGF (basic fibroblast growth factor), vitamin C, and EGF (epidermal growth factor). The NBVbe medium could support the isolation and expansion of human MSCs from the umbilical cords. Conclusions: The full chemical-defined medium supporting the isolation and expansion of human MSCs has been developed. This would be helpful for further optimization of the MSC medium, their clinical applications, and molecular characterization.

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“…In vivo, Ding et al (20) and Park et al (22) found that periodontal stem cells are bene cial for the treatment of a variety of in ammatory and immune diseases. Previous studies have demonstrated that the anti-in ammatory and immunosuppressive effects of MSCs depend on several different pathways, including direct cell contact and secretion of soluble factors (23,24), such as transforming growth factor-β (TGF-β), prostaglandin E2 (PGE2), hepatocyte growth factor (HGF), indoleamine 2, 3-dioxygenase (IDO), nitric oxide (NO), and interleukin-6 (IL-6). PDLSCs can inhibit the proliferation of allogeneic T lymphocytes, which is the result of the combined effect of direct cell contact and secretion of soluble factors (18,21).…”

Section: Introductionmentioning

confidence: 99%

The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells

Zhang

Wang

et al. 2020

Preprint

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Abstract Background: Periodontal ligament stem cells (PDLSCs) have many applications in the field of cytotherapy, tissue engineering, and regenerative medicine. However, the effect of age on the biological and immunological characteristics of PDLSCs remains unclear. Methods: In this study, we compared PDLSCs isolated from young and adult individuals. PDLSCs proliferation was analyzed by Cell Counting Kit-8 (CCK-8) and 5-ethynyl-2'-deoxyuridine (EdU) staining, and apoptosis level was detected by Annexin V-PE/7-ADD staining. PDLSCs osteogenic/adipogenic/chondrogenic differentiation potentials were assessed by alkaline phosphatase (ALP), Alizarin Red, Oil Red O, Alcian Blue staining and related quantitative analysis. PDLSCs immunosuppressive capacity was determined by EdU and Annexin V-PE/7-ADD staining. To explore its underlying mechanism, microarray, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), and western blot analyses were performed to detect differentially expressed genes and proteins in PDLSCs. Results: Our results demonstrated that with aging, the proliferation and osteogenic/adipogenic/chondrogenic differentiation potential of PDLSCs decreased, whereas apoptosis of PDLSCs increased. Moreover, the immunosuppressive ability of PDLSCs decreased with aging. Compared with PDLSCs from young subjects, analysis of mRNA expression revealed an upregulation of CCND3 and RC3H2, and a downregulation of Runx2, ALP, COL1A1, PPARγ2, CXCL12, FKBP1A, FKBP1B, NCSTN, P2RX7, PPP3CB, RIPK2, SLC11A1, and TP53 in those from adult individuals. Furthermore, protein expression levels of Runx2, ALP, COL1A1, and PPARγ2 in the adult group was decreased, whereas that of CCND3 increased. Conclusions: Taken together, aging influences biological and immunological characteristics of PDLSCs, and thus it is more appropriate to utilized PDLSCs from young individuals for tissue regeneration, post-aging treatment, and allotransplantation.

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Immune modulation by mesenchymal stem cells

Cited by 452 publications

References 245 publications

Efficacy of mesenchymal stem cells in animal models of lupus nephritis: a meta-analysis

Efficacy of mesenchymal stem cells in animal models of lupus nephritis: a meta-analysis

Chemical-defined medium supporting the expansion of human mesenchymal stem cells

The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells

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