Immune modulation of the liver metastatic colorectal cancer microenvironment via the oral CAPOX-mediated cGAS-STING pathway

Park, Seong Jin; Kweon, Seho; Moyo, Mudhibadhi Knowledge; Kim, Ha Rin; Choi, Jeong Uk; Lee, Na Kyeong; Maharjan, Ruby; Cho, Young Seok; Park, Jin Woo; Byun, Youngro

doi:10.1016/j.biomaterials.2024.122625

Biomaterials

2024

DOI: 10.1016/j.biomaterials.2024.122625

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Immune modulation of the liver metastatic colorectal cancer microenvironment via the oral CAPOX-mediated cGAS-STING pathway

Seong Jin Park,

Seho Kweon,

Mudhibadhi Knowledge Moyo

et al.

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Cited by 3 publications

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Attractive Pickering emulsion gel loaded with oxaliplatin and lactate dehydrogenase inhibitor increases the anti-tumor effect in hepatocellular carcinoma

Ye,

Zhang,

Shen

et al. 2024

Chinese Chemical Letters

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Attractive Pickering emulsion gel loaded with oxaliplatin and lactate dehydrogenase inhibitor increases the anti-tumor effect in hepatocellular carcinoma

Ye,

Zhang,

Shen

et al. 2024

Chinese Chemical Letters

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Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors

Catanzaro,

Beltrán-Visiedo,

Galluzzi

et al. 2024

Cell Mol Immunol

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While immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the clinical management of various malignancies, a large fraction of patients are refractory to ICIs employed as standalone therapeutics, necessitating the development of combinatorial treatment strategies. Immunogenic cell death (ICD) inducers have attracted considerable interest as combinatorial partners for ICIs, at least in part owing to their ability to initiate a tumor-targeting adaptive immune response. However, compared with either approach alone, combinatorial regimens involving ICD inducers and ICIs have not always shown superior clinical activity. Here, we discuss accumulating evidence on the therapeutic interactions between ICD inducers and immunotherapy with ICIs in oncological settings, identify key factors that may explain discrepancies between preclinical and clinical findings, and propose strategies that address existing challenges to increase the efficacy of these combinations in patients with cancer.

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Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform ‘cold’ tumors into ‘hot’ tumors

Ying,

Chen,

Yang

et al. 2024

Mol Cancer

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Immune modulation of the liver metastatic colorectal cancer microenvironment via the oral CAPOX-mediated cGAS-STING pathway

Cited by 3 publications

References 49 publications

Attractive Pickering emulsion gel loaded with oxaliplatin and lactate dehydrogenase inhibitor increases the anti-tumor effect in hepatocellular carcinoma

Attractive Pickering emulsion gel loaded with oxaliplatin and lactate dehydrogenase inhibitor increases the anti-tumor effect in hepatocellular carcinoma

Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors

Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform ‘cold’ tumors into ‘hot’ tumors

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