Immune modulatory effects of probioticStreptococcus thermophiluson human monocytes

Abstract

Ingesting probiotics contributes to the development of a healthy microflora in the gastrointestinal tract with established benefits to human health. Some of these beneficial effects may be through modulating of the immune system and probiotics have become more common in the treatment of many inflammatory and immune disorders. We demonstrate a range of immune modulating effects of Streptococcus thermophilus by human monocytes, including, decreased mRNA expression of IL-1R, IL-18, IFNγR1, IFNαR1, CCL2, CCR5, TLR-1, TLR-2, TLR-4, TLR-5, TLR-6, TLR-8, CD14, CD86, CD4, ITGAM, LYZ, TYK2, IFNR1, IRAK-1, NOD2, MYD88, ITGAM, SLC11A1, and, increased expression of IL-1α, IL-1β, IL-2, IL-6, IL-8, IL-23, IFNγ, TNFα, CSF-2. Routine administration of Streptococcus thermophilus in fermented dairy products, and their consumption may be beneficial to the treatment/management of inflammatory and autoimmune diseases.

Photobiological effect of eugenol‐derived 3‐benzoylcoumarin associated with led lights against MDR microorganisms

“…Another study reports more specifically the effect of using probiotic bacteria as an outlet for the treatment of diseases caused by bacteria that have already shown immunomodulatory effects, improving the immune system's response to bacteria, reducing the use of antibiotics, and may also represent an outlet for antimicrobial resistance [5].…”

Probiotics and gut microbiota: mechanistic insights into gut immune homeostasis through TLR pathway regulation

“…85 Likewise, Dargahi et al (2021) showed that probiotic bacterial DNA acts in an anti-inflammatory manner by introducing regulatory cytokine (IL-10) by Toll-like receptor-9 into dendritic cells. 86 These investigations suggest that probiotic nucleic acid, which acts as the central mediator of TLR9 signalling, can also be an active component mediating the immune response compared with whole bacteria.…”