Immune/Neural approach to characterize salivary gland neoplasms (SGN)

Monção, Carlos Rafael Lima; Santos, Emanuele; Prates, Thiago Silva; Paula, Alfredo Maurício Batista de; Cardoso, Cláudio Marcelo; Farias, Lucyana Conceição; Santos, Sérgio Henrique Sousa; D’Angelo, Marcos Flávio Silveira Vasconcelos; Guimarães, André Luiz Sena

doi:10.1016/j.asoc.2019.105877

Cited by 4 publications

(3 citation statements)

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“…EMT‐related genes have been extensively studied in OSCC and are associated with tumor progression and metastasis (Chen et al, 2017; Vallina et al, 2021). In OSCC, the process of glucose homeostasis, hypoxia, and angiogenesis is directly linked to OSCC's poor prognosis (da Rocha et al, 2019; de Carvalho Fraga et al, 2014; de Souza et al, 2020a; Fraga et al, 2012; Monção et al, 2020; Santos et al, 2021). OSCC cells can adapt in a hypoxic environment and shift to anaerobic metabolism (Fraga et al, 2012; Guimaraes et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Usually, patients with OSCC present with one or more risk factors for cancer development (Farias et al, 2010; Pinheiro et al, 2014). However, in some cases, no classical risk factors are present at OSCC diagnosis (de Souza et al, 2020; Monção et al, 2020). Although specific clinical characteristics have been identified (de Carvalho Fraga et al, 2014; Fonseca‐Silva et al, 2012; Santos et al, 2021), including lifestyle and human papillomavirus (HPV) status (Fonseca‐Silva et al, 2012; Marques‐Silva et al, 2012), it remains unclear what exactly initiates carcinogenesis or what facilitates intrinsic carcinogenesis, also known as non‐habit‐related carcinogenesis (de Souza et al, 2020b; Monção et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…However, in some cases, no classical risk factors are present at OSCC diagnosis (de Souza et al, 2020; Monção et al, 2020). Although specific clinical characteristics have been identified (de Carvalho Fraga et al, 2014; Fonseca‐Silva et al, 2012; Santos et al, 2021), including lifestyle and human papillomavirus (HPV) status (Fonseca‐Silva et al, 2012; Marques‐Silva et al, 2012), it remains unclear what exactly initiates carcinogenesis or what facilitates intrinsic carcinogenesis, also known as non‐habit‐related carcinogenesis (de Souza et al, 2020b; Monção et al, 2020). Some studies have reported that, generally, these cases are clinically more complex to treat, raising the hypothesis that this type of cancer develops through different routes of carcinogenesis (de Carvalho Fraga et al, 2014; De Paula et al, 2009; de Souza et al, 2020a; Farias et al, 2010; Fraga et al, 2012; Marques‐Silva et al, 2012; Santos et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Identification of potential biomarkers and survival analysis for oral squamous cell carcinoma: A transcriptomic study

et al. 2022

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ObjectiveOral squamous cell carcinoma (OSCC) is one of the most common neoplasms worldwide. The current study aimed to identify potential biomarkers associated with OSCC survival.Materials and MethodsDifferentially expressed genes (DEGs) in atypical OSCC cases were identified using two public datasets: The Cancer Genome Atlas and the Gene Expression Omnibus database. Receiver operating characteristic (ROC) analysis was performed to identify the cutoff, and the candidate DEGs related to survival. Kaplan–Meier and Cox regression analysis using the categorized genes were employed to identify genes that impact the overall survival in OSCC.ResultsA total of 263 OSCC samples and 105 healthy tissues were used to identify 295 upregulated and 131 downregulated genes expressed only in non‐smokers. ROC analyses identified 25 candidate genes associated with death. Survival analyses demonstrated that the following DEGs, namely CSTA, FGFR2, MMP19, OLR1, PCSK1, RAMP2, and CGB5, are potential OSCC prognostic factors.ConclusionWe found that CSTA, FGFR2, MMP19, OLR1, PCSK1, RAMP2, and CGB5 are associated with a low survival rate in OSCC. However, further studies are needed to validate our findings and facilitate the development of these factors as potential biomarkers for OSCC survival.

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