Immune priming with Candida albicans induces a shift in cellular immunity and gene expression of Musca domestica

Li, Zhongxun; Jia, Lina; Jiao, Zhenlong; Guo, Guo; Zhang, Yingchun; Xun, Hui; Shang, Xiaoli; Huang, Li; Wu, Jianwei

doi:10.1016/j.micpath.2022.105597

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…Delivering heat-killed bacteria to our migrant populations bolstered disease resistance in their offspring by enhancing cellular immunity. These data match previous work of immune priming across diverse insect taxa, including beetles, moths, butterflies, bees, flies, mosquitoes, and bugs Sheehan et al 2020;Sułek et al 2021;Li et al 2022;Gálvez et al 2024). Although the precise mechanisms underlying immune priming and their transgenerational effect are not fully understood, it might involve epigenetic alterations, particularly histone modifications, which facilitate heightened gene transcription upon subsequent exposure to pathogens (Sułek et al 2021).…”

Section: Integration Of Insect Immune Priming In Conservation Effortssupporting

confidence: 90%

’Disease-smart’ assisted migration can enhance population fitness and increase resistance to pathogens via immune priming

Ghosh,

Wallace,

Hufbauer

2024

Preprint

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We studied the potential of combining insect immune priming to synergize with introduction of diverse migrant to safeguard small populations from disease outbreaks that might otherwise lead to extinction.Immune priming in insects refers to the stronger immune response insects have against pathogens after prior exposure. This enhanced immunity can be passed on to offspring and holds promise for insect conservation efforts against diseases.We compared the fitness benefits to a small, inbred population of adding migrants that had not been primed to adding immune primed migrants. While both types of migrants enhanced reproduction, as in cases of genetic rescue, only primed migrants improved survival on exposure to a pathogen.Better immunity led to a trade-off with reproduction in the migrants, but not upon outcrossing with the target population, revealing synergies between hybrid vigor and immune priming.Given the demographic constraints and stochasticity that can exacerbate the effects of disease outbreaks in small populations, combining immune priming with assisted migration offers a proactive strategy to mitigate disease impacts.

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Section: Integration Of Insect Immune Priming In Conservation Effortssupporting

confidence: 90%

’Disease-smart’ assisted migration can enhance population fitness and increase resistance to pathogens via immune priming

Ghosh,

Wallace,

Hufbauer

2024

Preprint

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“…The flies used in this study were from populations found in poultry houses the year prior, and therefore would better reflect the population that would be found in a field setting than a colony that has been lab-reared for many years (Bryant and Meffert 1998). House flies do exhibit an immune response when infected with B. bassiana (Mishra et al 2015) so there may be some sort of immune priming at work in this interaction (Roth et al 2018, Li et al 2022). With possible repeated exposure in the field, these field populations may be better primed to survive a B. bassiana infection than a colony with no exposure history (Dubovskiy et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of the adult house fly (Diptera: Muscidae) and 3 of its principal parasitoids (Hymenoptera: Pteromalidae) to the GHA strain of Beauveria bassiana and 4 isolates from field-collected muscid flies

Pagac,

Geden,

Martin

et al. 2023

Journal of Medical Entomology

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House fly (Musca domestica L.) (Diptera: Muscidae) populations can negatively impact poultry layer facilities, posing a risk to human and animal health and egg food safety. House flies quickly develop resistance to traditional chemical control methods; therefore, improved biological control may provide opportunities for improved integrated pest management (IPM) programs. Biological control methods currently used include augmentative releases of pteromalid pupal parasitoids and application of the fungal entomopathogen Beauveria bassiana (Balsamo) Vuillemin. This study used bioassays to compare the impact of different B. bassiana strains on survival of house flies and of 3 species of filth fly parasitoids. The B. bassiana that were compared were 3 new field-collected isolates, an older field-collected isolate (L90), and a common commercially available strain (GHA). Flies and parasitoids were exposed to filter paper treated with 1.5 × 109 spores of each strain and a control. All field-isolated strains induced lower mean survival times in house flies than GHA did. The results for all species of parasitoids demonstrated less difference among the treatment groups and the control than in-house flies. Although there was some effect of B. bassiana exposure on parasitoid mortality, the expected spatial separation of parasitoids from areas of application may offer some protection. Using the most effective tested strains of B. bassiana and filth fly parasitoids jointly could be a biological component of an IPM plan for fly control in poultry facilities.

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“…Many studies indicated that immune priming occurs in many dipteran insects, including D. melanogaster and mosquitoes (Milutinović and Kurtz, 2016). Our previous study has confirmed that housefly larvae have the phenomenon of immune priming (Li et al, 2022). However, whether the housefly possesses TGIP is still unclear.…”

Section: Introductionmentioning

confidence: 91%

Pre-exposure to Candida albicans induce trans-generational immune priming and gene expression of Musca domestica

Jia²,

Yang³

et al. 2022

Front. Microbiol.

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Insects have the phenomenon of immune priming by which they can have enhanced protection against reinfection with the same pathogen, and this immune protection can be passed on to their offspring, which is defined as “trans-generational immune priming (TGIP).” But whether housefly possesses TGIP is still unclear. Therefore, we used the housefly as the insect model and Candida albicans as the pathogen to explore whether the housefly is capable of eliciting TGIP, and RNA sequencing (RNA-seq) was performed to explore the molecular mechanism of TGIP of the housefly. We found that the housefly possesses TGIP, and adults pre-exposed to heat-killed C. albicans could confer protection to itself and its offspring upon reinfection with a lethal dose of C. albicans. RNA-seq results showed that 30 and 154 genes were differentially expressed after adults were primed with heat-killed C. albicans (CA-A) and after offspring larvae were challenged with a lethal dose of C. albicans (CA-CA-G), respectively. Among the differentially expressed genes (DEGs), there were 23 immune genes, including 6 pattern recognition receptors (PRRs), 7 immune effectors, and 10 immunoregulatory molecules. More importantly, multiple DEGs were involved in the Toll signaling pathway and phagosome signaling pathway, suggesting that the Toll signaling pathway and phagocytosis might play important roles in the process of TGIP of housefly to C. albicans. Our results expanded on previous studies and provided parameters for exploring the mechanism of TGIP.

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Immune priming with Candida albicans induces a shift in cellular immunity and gene expression of Musca domestica

Cited by 6 publications

References 44 publications

’Disease-smart’ assisted migration can enhance population fitness and increase resistance to pathogens via immune priming

’Disease-smart’ assisted migration can enhance population fitness and increase resistance to pathogens via immune priming

Susceptibility of the adult house fly (Diptera: Muscidae) and 3 of its principal parasitoids (Hymenoptera: Pteromalidae) to the GHA strain of Beauveria bassiana and 4 isolates from field-collected muscid flies

Pre-exposure to Candida albicans induce trans-generational immune priming and gene expression of Musca domestica

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