Immune Privilege Revisited: The Roles of Neuronal MHC Class I Molecules in Brain Development and Plasticity

Ribic, Adema

doi:10.5772/47123

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Roles For Mhc-i In Brain Development and Synaptic Plasticity1

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2014

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“…It is well established that developing neurons express MHC-I (Shatz, 2009 ). A phenomenon implicated in development and maintenance of neuronal circuitry in the visual system (for review see Higenell and Ruthazer, 2010 ), the hippocampus, the cerebellum and the cortex (Ribic, 2012 ). Major histocompatibility complex I expression by developing neurons may be involved in retrograde signaling that regulates synaptic structure (Goddard et al, 2007 ).…”

Section: Roles For Mhc-i In Brain Development and Synaptic Plasticitymentioning

confidence: 99%

Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinsonâ€™s and other brain diseases

Cebrián¹,

Loike²,

Sulzer³

2014

Front. Neuroanat.

106

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Neuronal expression of major histocompatibility complex I (MHC-I) has been implicated in developmental synaptic plasticity and axonal regeneration in the central nervous system (CNS), but recent findings demonstrate that constitutive neuronal MHC-I can also be involved in neurodegenerative diseases by playing a neuroinflammtory role. Recent reports demonstrate its expression in vitro and in human postmortem samples and support a role in neurodegeneration involving proinflammatory cytokines, activated microglia and increased cytosolic oxidative stress. Major histocompatibility complex I may be important for both normal development and pathogenesis of some CNS diseases including Parkinson's.

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Section: Roles For Mhc-i In Brain Development and Synaptic Plasticitymentioning

confidence: 99%

Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinsonâ€™s and other brain diseases

Cebrián¹,

Loike²,

Sulzer³

2014

Front. Neuroanat.

106

View full text Add to dashboard Cite

show abstract

Immune Privilege Revisited: The Roles of Neuronal MHC Class I Molecules in Brain Development and Plasticity

Cited by 1 publication

References 34 publications

Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinsonâ€™s and other brain diseases

Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinsonâ€™s and other brain diseases

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