Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity

Navarro, Rocío; Compte, Marta; Álvarez‐Vallina, Luís; Sanz, Laura

doi:10.3389/fimmu.2016.00480

Cited by 127 publications

(105 citation statements)

References 109 publications

(114 reference statements)

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“…Human lung PDGFR-␤ϩ pericytes express proinflammatory chemokines in response to stimulation by PAMPs and DAMPs in vitro. Pericytes are increasingly being recognized as cells important in immunomodulation and tissue repair (30,43). Isolated pericytes from rodent lungs, as well as human and mouse brain, kidney and placenta, elaborate a number of chemokines and cell adhesion molecules in response to stimulation by PAMPs and DAMPs (14 -16, 24, 26, 28, 33, 42).…”

Section: L996mentioning

confidence: 99%

Characterization of human PDGFR-β-positive pericytes from IPF and non-IPF lungs

Wilson

Stephenson

Higuero

et al. 2018

American Journal of Physiology-Lung Cellular and Molecular Phys

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Pericytes are key regulators of the microvasculature through their close interactions with the endothelium. However, pericytes play additional roles in tissue homeostasis and repair, in part by transitioning into myofibroblasts. Accumulation of myofibroblasts is a hallmark of fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). To understand the contribution and role of pericytes in human lung fibrosis, we isolated these cells from non-IPF control and IPF lung tissues based on expression of platelet-derived growth factor receptor-β (PDGFR-β), a common marker of pericytes. When cultured in a specialized growth medium, PDGFR-β+ cells retain the morphology and marker profile typical of pericytes. We found that IPF pericytes migrated more rapidly and invaded a basement membrane matrix more readily than control pericytes. Exposure of cells to transforming growth factor-β, a major fibrosis-inducing cytokine, increased expression of α-smooth muscle actin and extracellular matrix genes in both control and IPF pericytes. Given that pericytes are uniquely positioned in vivo to respond to danger signals of both systemic and tissue origin, we stimulated human lung pericytes with agonists having pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs). Both control and IPF lung pericytes increased expression of proinflammatory chemokines in response to specific PAMPs and DAMPs released from necrotic cells. Our results suggest that control and IPF lung pericytes are poised to react to tissue damage, as well as microbial and fibrotic stimuli. However, IPF pericytes are primed for migration and matrix invasion, features that may contribute to the function of these cells in lung fibrosis.

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Section: L996mentioning

confidence: 99%

Characterization of human PDGFR-β-positive pericytes from IPF and non-IPF lungs

Wilson

Stephenson

Higuero

et al. 2018

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…Ebert and C.M.B. Rouget [73] and were named by K.W. Zimmermann describing their contractile nature in 1923 [74].…”

Section: In Vivo Function Of Pericyte-mscmentioning

confidence: 99%

Stem cells in the treatment of diabetes mellitus — Focus on mesenchymal stem cells

et al. 2019

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“…In tumor tissue, pericytes highly express αSMA, although it is often absent in quiescent pericytes in non-tumoral tissue. Recent experimental studies revealed that pericytes can actively modulate the magnitude of immune responses and may prevent lymphocyte extravasation and activation in tumor tissue [9].…”

Section: Angiogenic Vascular Cellsmentioning

confidence: 99%

Significance of Tumor Microenvironment Scoring and Immune Biomarkers in Patient Stratification and Cancer Outcomes

Alsibai¹,

Meseure²

2018

Histopathology - An Update

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Tumors appear as heterogeneous tissues that consist of tumor cells surrounding by a tumor microenvironment (TME). TME is a complex network composed of extracellular matrix (ECM), stromal cells, and immune/inflammatory cells that drive cancer cells fate from invasion to intravasation and metastasis. The stromal-inflammatory interface represents a dynamic space, in which exchange of numerous molecular information is associated with the transition into tumorigenic microenvironment. Recruitment, activation, and reprogramming of stromal and immune/inflammatory cells in the extracellular space are the consequences of a reciprocal interaction between TME and cancer cells. Recent data suggest that cancer development is influenced by TME and controlled by the host's immune system, underlying the importance of TME components and immune biomarkers in the determination of prognosis and response to therapy. The immune classification has prognostic value and may be a useful supplement to the histopathological, molecular, and TNM classifications. Nevertheless, the complexity of quantitative immunohistochemistry and the variable assay protocols, stromal and immune cell types analyzed underscore the need to harmonize the quantified methods. It is therefore important to incorporate TME and immune scoring in determinations of cancer prognosis and to make sure they become a routine part of the histopathological diagnostic and prognostic assessment of patients.

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Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity

Cited by 127 publications

References 109 publications

Characterization of human PDGFR-β-positive pericytes from IPF and non-IPF lungs

Characterization of human PDGFR-β-positive pericytes from IPF and non-IPF lungs

Stem cells in the treatment of diabetes mellitus — Focus on mesenchymal stem cells

Significance of Tumor Microenvironment Scoring and Immune Biomarkers in Patient Stratification and Cancer Outcomes

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