Immune regulation in neurovascular units after traumatic brain injury

Wang, Zongqi; Chen, Gang

doi:10.1016/j.nbd.2023.106060

Cited by 5 publications

(1 citation statement)

References 142 publications

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“…Regarding respiratory infections, it is supposed that the germ colonizes the respiratory airways and then it can cause infection if the host passes through a state of immunocompromise, its activity being similar to that of an opportunistic pathogen. If treated with the correct antibiotics, the patient usually recovers from this infection [4], but there are also cases reported to have led to death [5,6]. Despite its opportunistic nature, there is limited understanding of its pathogenicity, diagnostic challenges, and optimal treatment strategies, particularly in immunocompromised individuals.…”

Section: Introductionmentioning

confidence: 99%

Uncovering the Unseen: Bordetella hinzii Emerges in a Lung Transplant Recipient

Vulturar,

Pilmis,

Rouzaud

et al. 2024

IJMS

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Bordetella hinzii (B. hinzii), a Gram-negative bacillus commonly associated with respiratory infections in animals, has garnered attention for its sporadic cases in humans, particularly in immunocompromised individuals. Despite its opportunistic nature, there remains limited understanding regarding its pathogenicity, diagnostic challenges, and optimal treatment strategies, especially in the context of immunosuppression. Herein, we present the first documented case of acute bronchitis caused by B. hinzii in an immunocompromised patient following double-lung transplantation. The patient, a former smoker with sarcoidosis stage IV, underwent transplant surgery and subsequently developed a febrile episode, leading to the identification of B. hinzii in broncho-alveolar lavage samples. Antimicrobial susceptibility testing revealed resistance to multiple antibiotics, necessitating tailored treatment adjustments. Our case underscores the importance of heightened awareness among clinicians regarding B. hinzii infections and the imperative for further research to elucidate its epidemiology and optimal management strategies, particularly in immunocompromised populations.

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Section: Introductionmentioning

confidence: 99%

Uncovering the Unseen: Bordetella hinzii Emerges in a Lung Transplant Recipient

Vulturar,

Pilmis,

Rouzaud

et al. 2024

IJMS

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Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions

Wong,

Lee,

Sng

et al. 2023

Neuromol Med

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Vaccines for immunological defense against traumatic brain injury

Lintecum,

Thumsi,

Dunn

et al. 2024

Preprint

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Traumatic brain injury (TBI) and subsequent neurodegeneration is partially driven by chronic inflammation both locally and systemically. Yet, current clinical intervention strategies do not mitigate inflammation sequalae necessitating the development of innovative approaches to reduce inflammation and minimize deleterious effects of TBI. Herein, a subcutaneous formulation based on polymer of alpha-ketoglutarate (paKG) delivering glycolytic inhibitor PFK15 (PFKFB3 inhibitor, a rate limiting step in glycolysis), alpha-ketoglutarate (to fuel Krebs cycle) and peptide antigen from myelin proteolipid protein (PLP139-151) was utilized as the prophylactic immunosuppressive formulation in a mouse model of TBI. In vitro, the paKG(PFK15+PLP) vaccine formulation stimulated proliferation of immunosuppressive regulatory T cells and induced generation of T helper-2 cells. When given subcutaneously in the periphery to two weeks prior to mice sustaining a TBI, the active vaccine formulation increased frequency of immunosuppressive macrophages and dendritic cells in the periphery and the brain at day 7 post-TBI and by 28 days post-TBI enhanced PLP-specific immunosuppressive cells infiltrated the brain. While immunohistology measurements of neuroinflammation were not altered 28 days post-TBI, the vaccine formulation improved motor function and enhanced autophagy mediated genes in a spatial manner in the brain. Overall, these data suggest that the TBI vaccine formulation successfully induced an anti-inflammatory profile and decreased TBI-associated inflammation.

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Immune regulation in neurovascular units after traumatic brain injury

Cited by 5 publications

References 142 publications

Uncovering the Unseen: Bordetella hinzii Emerges in a Lung Transplant Recipient

Uncovering the Unseen: Bordetella hinzii Emerges in a Lung Transplant Recipient

Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions

Vaccines for immunological defense against traumatic brain injury

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