2018
DOI: 10.1016/j.jneuroim.2018.01.005
|View full text |Cite
|
Sign up to set email alerts
|

Immune-related miRNA expression patterns in peripheral blood mononuclear cells differ in multiple sclerosis relapse and remission

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
40
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 50 publications
(41 citation statements)
references
References 62 publications
1
40
0
Order By: Relevance
“…Because exosomes were shown to contribute to intercellular communication by transporting signals into the target cells either close to or distant from the cells of exosome origin [12,16], we investigated the effect of RA-exosomes on Treg differentiation and found that RA-exosomes could inhibit Treg differentiation in vitro. Because miRNA has been shown to play an important role in the differentiation and function of immune cells [18][19][20][21][22][23], we next analyzed miRNA expression profiles in RA-exosomes as compared with those in HC-exosomes by microarray analysis. The results showed remarkable differences in miRNA profiles between RA-exosomes and HC-exosomes.…”
Section: Discussionmentioning
confidence: 99%
“…Because exosomes were shown to contribute to intercellular communication by transporting signals into the target cells either close to or distant from the cells of exosome origin [12,16], we investigated the effect of RA-exosomes on Treg differentiation and found that RA-exosomes could inhibit Treg differentiation in vitro. Because miRNA has been shown to play an important role in the differentiation and function of immune cells [18][19][20][21][22][23], we next analyzed miRNA expression profiles in RA-exosomes as compared with those in HC-exosomes by microarray analysis. The results showed remarkable differences in miRNA profiles between RA-exosomes and HC-exosomes.…”
Section: Discussionmentioning
confidence: 99%
“…[160][161][162][163]168 Also, cigarette smoking could downregulate miR-21-5p in SPMS, more specifically in the relapse phases (Tables 1 and 2). 115,139,193 This miRNA could target numerous MS risk genes, including SLC2A4RG, MALT1, STAT3, TAGAP, DDAH1, and IL12A, as indicated by the GWS and IMSGC studies (Table 3). [160][161][162][163]166,167 Notably, maternal tobacco smoking could induce miR-223 upregulation in the blood, which subsequently affected Treg counts and functionality (Table 1).…”
Section: Data Extractionmentioning
confidence: 96%
“…[160][161][162][163] miR-126 was recently found to be significantly upregulated in RRMS cases. 139,242 miR-181c could promote Th17 differentiation, induce autoimmunity, and mediate EAE and was upregulated in the peripheral blood and the CSF of MS patients. 22,159,243 Furthermore, cigarette smoking could cause a global decrease in miRNAs profiles in alveolar MØ.…”
Section: Data Extractionmentioning
confidence: 99%
“…This result confirms previous studies on the impact of miRNAs on the transcriptional network in MS pathogenesis. 23,[28][29][30][31] Our research demonstrates for the first time that the CSF profile of remitting MS (Rem) is more closely related to the profile of controls than relapsing MS (Rel) because (1) the SiPas target analysis scores were the lowest (if not absent) for the miRNAs differentially expressed between Rem vs SC (Rem/SC), whereas the scores were the highest for the ones between Rel/Rem and (2) that no common SiPas specifically stood out for the dysregulated miRNAs in Rel and Rem compared with controls. At the mRNA level, it is worth noting that, unlike most of the genes regulated by miRNAs from all groups, PLAGL2 and LMNB2 were specifically clustered to the Rel/Rem and Rem/SC subgroups.…”
Section: Csf-predominant Mirna Dysregulation and Mirna Species Newly mentioning
confidence: 99%