Immune response in families of children with acute lymphoblastic leukaemia

Evans, D. I. K.

doi:10.1136/adc.48.6.441

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…The results in ALL mothers did not confirm the raised IgM reported by Sutton et al (1969) and Chandra (1972), the raised IgG reported by Chandra (1972) and Hann et al (1975) or the raised IgA reported by Hann et al (1975). Evans (1973) similarly failed to find these differences.…”

Section: Discussionmentioning

confidence: 77%

“…As it is impossible to distinguish between immunodeficiency of genetic origin and that resulting from the leukaemia or its treatment in the patients themselves, attempts have been made to uncover predisposing genetic immunodeficiency by studying the patients' relatives. Results of leucocyte counts, immunoglobulin estimations and lymphocyte transformation tests in the parents of children with leukaemia have shown no consistent differences from controls (Sutton et al, 1969;Chandra, 1972;Evans, 1973;Hann et al, 1975), but these measures are very crude indicators of immune function.…”

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confidence: 99%

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Family studies in acute leukaemia in childhood: a possible association with autoimmune disease

Till¹,

Rapson²,

Smith³

1979

Br J Cancer

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Summary.-Medical histories of themselves and their first-degree relatives were obtained from parents of 82 leukaemic children (54 acute lymphoblastic (ALL), 28 acute myeloblastic (AML)) and from control couples matched for age. The possibility of a primary familial immunological abnormality as an aetiological factor in childhood leukaemia was suggested by finding some infections significantly more frequently reported in parents than in controls, but more strongly supported by the finding of a significantly (P<0-02) increased prevalence of disorders associated with autoimmunity (but not of other conditions such as peptic ulceration, infective hepatitis, tuberculosis or malignancy) amongst members of ALL families compared to those of controls. Analogy with Down's syndrome and the strain of NZB mice, in which diminished T-cell function is associated with autoimmune disease and lymphoid neoplasia, is discussed.Varicella and herpes zoster occurred respectively in 2 ALL mothers during their pregnancies involving the patients and in none of the other 388 pregnancies here reported. This supports previous evidence that antenatal varicella infections may be of aetiological importance in some cases of ALL.

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Section: Discussionmentioning

confidence: 77%

mentioning

confidence: 99%

Family studies in acute leukaemia in childhood: a possible association with autoimmune disease

Till¹,

Rapson²,

Smith³

1979

Br J Cancer

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“…aiid defective polyiiiorph bacterial killing in both patients (Gregory et al, 1972) and their parents (Thompson, 1972). The oiily other inimuiiological study in fathers failed to detect abnormality either in tlieiii or in the mothers of a sinall series (Evans, 1973). We have previously interpreted the maternal abnormalities as suggestive of chronic virus infection, which could either be vertically transmitted via the ovum or cross the placental barrier to affect the foetus in utero.…”

Section: Discussionmentioning

confidence: 88%

Leukaemia in Children and. their Grandparents: Studies of Immune Function in Six Families

et al. 1975

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Seven of 500 children with acute leukaemia seen over a 15-year period were known to have a close relative with leukaemia or lymphoma. In each case the affected relative was a grandparent of the child, six of the seven being paternal grandparents. Investigation of thses six families showed that the fathers, who had two affected first-degree relatives, had lower lymphocyte counts and higher serum IgA concentrations than paired controls. Atopy, repeated infections and rheumatic disease were common amongst the parents and their sibs. The findings suggest a possible immunodeficiency basis for leukaemia in these families and perhaps also for acute lymphoblastic leukaemia of childhood in general. In the only family in which three generations, including both leukaemic patients, were available for HL-A typing, the affected grandson had not inherited either of his affected grandmother's haplotypes.

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Abnormal lymphocyte function in childhood leukemia

Zusman

Nesbit

1979

Med. Pediatr. Oncol.

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(1 0 f 3% lymphocytes, 88 f 4% lymphoblasts and 18 k 28% T cells) had a significantly lower response to PHA on these days (13,609 * 5,568 cpm).Six of the ten high-WBC patients had a delayed peak response on the sixth or seventh day of culture. This abnormal response to PHA is similar to that which has been described in patients with chronic lymphatic leukemia and is at least partially due to the dilution of a normal lymphocyte population by the proliferation of a population of non-PHA-responsive lymphoblasts.The remaining four high-WBC patients had flat PHA dose-and time-response curves and a poorer clinical course. Two of them had T-cell leukemia. The absence of response to PHA in these children may characterize a group of patients with acute lymphoblastic leukemia who are immunodeficient at the time of diagnosis and may reflect the presence of a unique population of lymphoblasts with suppressor activity.Sixteen patients with a WBC < 20,000/ cu mm (5 1 f 5% lymphocytes, 28 f 7%

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Immune response in families of children with acute lymphoblastic leukaemia

Cited by 5 publications

References 17 publications

Family studies in acute leukaemia in childhood: a possible association with autoimmune disease

Family studies in acute leukaemia in childhood: a possible association with autoimmune disease

Leukaemia in Children and. their Grandparents: Studies of Immune Function in Six Families

Abnormal lymphocyte function in childhood leukemia

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