Immune Response in Human Amebiasis: A Protective Response?

Ximénez, Cecilia; Partida, Oswaldo; Nieves, Miriam; Hernández, E.; Morán, Patricia; Valadéz, Alicia; González, Enrique A.; Cerritos, René; Rojas, Liliana

doi:10.1007/978-4-431-55200-0_29

Cited by 2 publications

(2 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Enteric pathogenic protozoa and bacteria are a frequent cause of intestinal disease which, in turn, is an important cause of morbidity and mortality around the world [ 1 ]. Two important etiological agents of intestinal parasitic diseases are the protozoa Giardia intestinalis and Entamoeba histolytica , which have been estimated to affect 280 million and 50 million people worldwide each year, respectively [ 2 , 3 ]. Furthermore, some bacterial strains have been identified as responsible for severe intestinal illness.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of 2H-Indazole Derivatives: Towards Antimicrobial and Anti-Inflammatory Dual Agents

et al. 2017

View full text Add to dashboard Cite

Indazole is considered a very important scaffold in medicinal chemistry. It is commonly found in compounds with diverse biological activities, e.g., antimicrobial and anti-inflammatory agents. Considering that infectious diseases are associated to an inflammatory response, we designed a set of 2H-indazole derivatives by hybridization of cyclic systems commonly found in antimicrobial and anti-inflammatory compounds. The derivatives were synthesized and tested against selected intestinal and vaginal pathogens, including the protozoa Giardia intestinalis, Entamoeba histolytica, and Trichomonas vaginalis; the bacteria Escherichia coli and Salmonella enterica serovar Typhi; and the yeasts Candida albicans and Candida glabrata. Biological evaluations revealed that synthesized compounds have antiprotozoal activity and, in most cases, are more potent than the reference drug metronidazole, e.g., compound 18 is 12.8 times more active than metronidazole against G. intestinalis. Furthermore, two 2,3-diphenyl-2H-indazole derivatives (18 and 23) showed in vitro growth inhibition against Candida albicans and Candida glabrata. In addition to their antimicrobial activity, the anti-inflammatory potential for selected compounds was evaluated in silico and in vitro against human cyclooxygenase-2 (COX-2). The results showed that compounds 18, 21, 23, and 26 display in vitro inhibitory activity against COX-2, whereas docking calculations suggest a similar binding mode as compared to rofecoxib, the crystallographic reference.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of 2H-Indazole Derivatives: Towards Antimicrobial and Anti-Inflammatory Dual Agents

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The circumstances that define the extraintestinal invasive behavior of some E. histolytica strains remain unknown today. However, this seems to be an infrequent event as suggested by the low morbidity rates of amoebic liver abscess and other extraintestinal forms of invasive amoebiasis compared with the prevalence rates of asymptomatic infections and intestinal disease, and fortunately, in the last decade, such complications are uncommon [25,26].…”

Section: The Severe Forms Of Amoebiasismentioning

confidence: 99%

Amoebiasis: Advances in Diagnosis, Treatment, Immunology Features and the Interaction with the Intestinal Ecosystem

Morán

Serrano-Vázquez

Rojas-Velázquez

et al. 2023

IJMS

View full text Add to dashboard Cite

This review of human amoebiasis is based on the most current knowledge of pathogenesis, diagnosis, treatment, and Entamoeba/microbiota interactions. The most relevant findings during this last decade about the Entamoeba parasite and the disease are related to the possibility of culturing trophozoites of different isolates from infected individuals that allowed the characterization of the multiple pathogenic mechanisms of the parasite and the understanding of the host–parasite relationship in the human. Second, the considerable advances in molecular biology and genetics help us to analyze the genome of Entamoeba, their genetic diversity, and the association of specific genotypes with the different amoebic forms of human amoebiasis. Based on this knowledge, culture and/or molecular diagnostic strategies are now available to determine the Entamoeba species and genotype responsible for invasive intestinal or extraintestinal amoebiasis cases. Likewise, the extensive knowledge of the immune response in amoebiasis with the appearance of new technologies made it possible to design diagnostic tools now available worldwide. Finally, the understanding of the interaction between the Entamoeba species and the intestinal microbiota aids the understanding of the ecology of this parasite in the human environment. These relevant findings will be discussed in this review.

show abstract

Immune Response in Human Amebiasis: A Protective Response?

Cited by 2 publications

References 116 publications

Synthesis and Biological Evaluation of 2H-Indazole Derivatives: Towards Antimicrobial and Anti-Inflammatory Dual Agents

Synthesis and Biological Evaluation of 2H-Indazole Derivatives: Towards Antimicrobial and Anti-Inflammatory Dual Agents

Amoebiasis: Advances in Diagnosis, Treatment, Immunology Features and the Interaction with the Intestinal Ecosystem

Contact Info

Product

Resources

About