Immune response of non-pathogenic Gram(+) and Gram(−) bacteria in inductive sites of the intestinal mucosaStudy of the pathway of signaling involved

Dogi, Cecilia Ana; Weill, Federico S.; Perdigón, Gabriela

doi:10.1016/j.imbio.2009.01.005

Cited by 22 publications

(19 citation statements)

References 29 publications

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“…However, pretreatment with Hsp65 LL had no effect on any of the T-cell subsets tested. Some studies have shown that generation of Treg cells is triggered by ingestion of probiotic bacteria (Dogi et al, 2010;Jang et al, 2012). Jang and collaborators (2012) showed that the previous administration of Lactobacillus rhamnosus and/or Bifidobacterium longum, in experimental models of OVA-induced food allergy and asthma, was able to increase the frequency of CD4 + CD25 + T cells in the spleen and mLN from allergic animals when compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Previous Ingestion ofLactococcus lactisby Ethanol-Treated Mice Preserves Antigen Presentation Hierarchy in the Gut and Oral Tolerance Susceptibility

Perez

Gomes-Santos

Miyoshi

et al. 2015

Alcohol Clin Exp Res

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Section: Discussionmentioning

confidence: 99%

Previous Ingestion ofLactococcus lactisby Ethanol-Treated Mice Preserves Antigen Presentation Hierarchy in the Gut and Oral Tolerance Susceptibility

Perez

Gomes-Santos

Miyoshi

et al. 2015

Alcohol Clin Exp Res

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“…TLR-2 and TLR-4 activation by probiotic microorganisms are recognized as particularly important receptors mediating the direct influence of probiotic and commensal bacteria on inflammatory signaling pathways [12,49]; TLR-9 also is identified as an important receptor for mediating the anti-inflammatory effect of certain probiotic strains [12,50].…”

Section: Direct Effects: 1) Act As Ligands For Innate Immune System Rmentioning

confidence: 99%

Probiotics as regulators of inflammation: A review

Lescheid¹

2014

FFHD

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A substantial and increasing body of clinical evidence supports the role of specific strains and mixtures of probiotics in the prevention and treatment of certain diseases. Several general mechanisms of action have been proposed, including supporting repair of hyperpermeable epithelial barriers, interfering with infection by pathogens, and restoring a healthful balance of commensal microbes to affect metabolism. Emerging evidence supports an additional role of probiotics as important modulators of immune system responses, including inflammation, at mucosal surfaces. In particular, by preventing or repairing ‘leaky’ epithelial barriers, probiotics can indirectly affect the inflammatory response by negating the source of pro-inflammatory stimuli associated with low-grade endotoxemia. They also enhance production of short chain fatty acids with anti-inflammatory properties (e.g. butyrate) as well as increase synthesis of antimicrobial peptides that influence inflammation resolution pathways in the mucosa. Furthermore, probiotics and some of their secreted metabolic products can act as ligands for innate immune system receptors, directly influencing key pro-inflammatory pathways. They also stimulate the differentiation and activity of important immune cells (e.g., dendritic cells, T cells), and subsequently increase production of important regulatory cytokines, including interleukin-10 (IL-10) and transforming growth factor-beta (TGF-b). Finally, there are limited but increasing animal studies and clinical trials demonstrating probiotics do affect common biomarkers of inflammation, including C-reactive protein, as well as signs and symptoms of the associated diseases suggesting they can have therapeutic benefit in the treatment of chronic inflammatory disease.Keywords: probiotics, inflammation, endotoxemia, epithelial, cytokines, immune, butyrate, antimicrobial peptides

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“…Some strains not only modulate mucosal immune functions upon oral administration (e.g., lipoteichoic acid in wild-type Lactobacillus strains, L. plantarum NCIMB8826 and Gram-positive strains) but also have immunostimulatory properties and provide a strategy to influence cytokine expression and immune responses (Dogi, Weill, & Perdigó n, 2010;Grangette et al, 2005;Maassen et al, 2000). Some enhance the Th1 response through the release of pro-inflammatory cytokines such as IL-1b, TNF-a, IL-12 and IL-18, whereas others are anti-inflammatory cytokines such as IL-10 and TGF-b (Hessle, Andersson, & Wold, 2000;Matsuguchi et al, 2003;Miettinen et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effects of deadLactobacilluson murine splenocytes and macrophages

Chiang

Liu

Tseng

et al. 2012

Food and Agricultural Immunology

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To elucidate the immunomodulation effects of dead lactobacilli, whole cells and gastrointestinal enzymatic hydrolysates of supernatants and precipitates from Lactobacillus paracasei subsp. paracasei NTU 101 and L. plantarum NTU 102 on RAW264.7 macrophages and splenocytes were investigated. Increased NO, COX-2 expression, IL-10 and IL-12 were observed in high-dose precipitates and whole cells of both strains after 24-h stimulation. All of the hydrolysates and whole cells from both strains induced lower pro-inflammatory cytokines (IL-1b and IL-6) than LPS. The supernatants activated cell division to the S phase or promoted advance to the G2/M phase. Regardless of the Lactobacillus strains, higher levels of TNF-a, IL-6, IL-10 and IL-12 in splenocytes were induced by the precipitates. Supernatant of NTU 101 increased the amounts of IFN-g than precipitate in splenocytes. It shows that hydrolysates of NTU 101 induce the proliferations of macrophage and splenocyte and the release of IL-10 and IL-12 cytokines to modulate the innate and adaptive immune systems and inflammatory response.

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Immune response of non-pathogenic Gram(+) and Gram(−) bacteria in inductive sites of the intestinal mucosaStudy of the pathway of signaling involved

Cited by 22 publications

References 29 publications

Previous Ingestion ofLactococcus lactisby Ethanol-Treated Mice Preserves Antigen Presentation Hierarchy in the Gut and Oral Tolerance Susceptibility

Previous Ingestion ofLactococcus lactisby Ethanol-Treated Mice Preserves Antigen Presentation Hierarchy in the Gut and Oral Tolerance Susceptibility

Probiotics as regulators of inflammation: A review

Immunomodulatory effects of deadLactobacilluson murine splenocytes and macrophages

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