Immune response of the elderly to rabies vaccines

Mastroeni, I; Vescia, N; Mg, Pompa; Cattaruzza, Maria Sofia; Marini, Giancarlo; Fara, Gaetano Maria

doi:10.1016/0264-410x(94)90310-7

Cited by 35 publications

(16 citation statements)

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“…see refs. (439,440). However, the confounding effects of underlying disease make studies of age-related changes in the response to vaccination even more fraught with difficulty than for the cytokine secretion data (see section 4.4).…”

Section: Vaccination (See Also Section 41)mentioning

confidence: 99%

T cells and aging (update February 1999)

Pawelec

1999

Front Biosci

113

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T cell immunosenescence 218effects of dysregulated immune responses in the elderly by supplementation or other approaches may result in an enhancement of their quality of life, and significant reductions in the cost of medical care in old age. FACTORS CONTRIBUTING TO IMMUNO-SENESCENCE HematopoiesisDysregulated hematopoiesis is seen in elderly individuals, raising the possibility that this could contribute to altered immune function in the aged. Hematopoiesis in man may be compromised because of a severely reduced capacity to produce colony stimulating factors (44) and increased production of pro-inflammatory factors such as IL 6 (45), because lower numbers of progenitor cells are present in the BM (46) and because of an age-related decline in proliferative potential of putative haematopoietic stem cells (HSC) (47). In mice, the repopulating potential of murine fetal liver-derived HSC is higher than that of adult BM-derived stem cells (48), suggesting possible aging of the HSC themselves. Normal cells with shorter telomeres possess less remaining replicative capacity than those with longer telomeres (see section 5.2). Accordingly, HSC from adult BM were found to have shorter telomeres than fetal liver-derived or umbilical cord-derived stem cells, consistent with aging of HSC (49). Telomere lengths decreased on culture despite low level expression of telomerase in these cells (50,51), although the rate of basepair loss per population doubling of cells in culture was lower during the first two weeks, when telomerase was upregulated, than in the next two, when it was downregulated (52). The telomerase expressed is therefore functionally active but may not be able to completely maintain telomere length in aging HSC cells. True embryonic stem cells (ESC), on the other hand, which may really be immortal, do retain high levels of telomerase activity (53). On the other hand, ESC from telomerase-knockout mice show gradual telomere shortening over many population doublings (PD) resulting in slowing and eventual cessation of growth (54). Certain animals which do not downregulate telomerase manifest a permanent growth phase and little or no senescence (55,56).

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Section: Vaccination (See Also Section 41)mentioning

confidence: 99%

T cells and aging (update February 1999)

Pawelec

1999

Front Biosci

113

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“…Studies in humans and animal models have demonstrated aging-associated defects in selected inductive and effector T cell functions, most notably, decreased reactivity to Ag, impaired delayed hypersensitivity response to recall Ag, and diminished T cell-dependent Ab response after vaccination (1)(2)(3). However, the notion that the aging-associated "decline" in immune response is the cause of diminished protective immunity and poor clinical outcome in the elderly is not supported by available evidence.…”

mentioning

confidence: 99%

“…Ligands of chemokine receptors also affect their function. CCR5-using chemokines (RANTES, macrophage-inflammatory protein (MIP) 3 -1␣, MIP-1␤) can block M-tropic HIV strains, whereas the CXCR4 ligand stromal cell-derived factor (SDF)-1 blocks T-tropic strains by down-regulating the receptor (14). The clinical courses of these T cell chemokine-dependent diseases are different in the elderly compared with younger individuals (17,18).…”

mentioning

confidence: 99%

T Cell Chemokine Receptor Expression in Aging

Chen

Yin

et al. 2003

The Journal of Immunology

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Changes in chemokine receptor expression are important in determining T cell migration and the subsequent immune response. To better understand the contribution of the chemokine system in immune senescence we determined the effect of aging on CD4+ T cell chemokine receptor function using microarray, RNase protection assays, Western blot, and in vitro chemokine transmigration assays. Freshly isolated CD4+ cells from aged (20–22 mo) mice were found to express a higher level of CCR1, 2, 4, 5, 6, and 8 and CXCR2–5, and a lower level of CCR7 and 9 than those from young (3–4 mo) animals. Caloric restriction partially or completely restored the aging effects on CCR1, 7, and 8 and CXCR2, 4, and 5. The aging-associated differences in chemokine receptor expression cannot be adequately explained by the age-associated shift in the naive/memory or Th1/Th2 profile. CD4+ cells from aged animals have increased chemotactic response to stromal cell-derived factor-1 and macrophage-inflammatory protein-1α, suggesting that the observed chemokine receptor changes have important functional consequences. We propose that the aging-associated changes in T cell chemokine receptor expression may contribute to the different clinical outcome in T cell chemokine receptor-dependent diseases in the elderly.

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“…3 Their case is a 73-year-old man. This point should be considered as a confounding factor which can inversely affect antibody response to rabies vaccination.…”

Section: Please Scroll Down For Articlementioning

confidence: 98%

Immune response following postexposure rabies prophylaxis

Gözdaş

2015

Human Vaccines & Immunotherapeutics

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Immune response of the elderly to rabies vaccines

Cited by 35 publications

References 1 publication

T cells and aging (update February 1999)

T cells and aging (update February 1999)

T Cell Chemokine Receptor Expression in Aging

Immune response following postexposure rabies prophylaxis

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