Immune response to acetaldehyde-human serum albumin adduct among healthy subjects related to alcohol intake

Romanazzi, Valeria; Schilirò, Tiziana; Carraro, Elisabetta; Gilli, Giorgio

doi:10.1016/j.etap.2013.05.002

Cited by 10 publications

(8 citation statements)

References 30 publications

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“…For instance, we discovered increased activity and migration of several cell types related to the innate immune response in male AUD patients. This increase might relate to an augmented response upon the presence of pathogens and inflammation, and studies have related an increased inflammatory response to AUD [ 55 , 56 ], which might be related to a decrease in the production of tumor necrosis factor-α. However, the innate immune response may be depressed in female AUD patients, making them more vulnerable to infections.…”

Section: Discussionmentioning

confidence: 99%

Unveiling Sex-Based Differences in the Effects of Alcohol Abuse: A Comprehensive Functional Meta-Analysis of Transcriptomic Studies

Ferrer

Pascual

Hidalgo

et al. 2020

Genes

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The abuse of alcohol, one of the most popular psychoactive substances, can cause several pathological and psychological consequences, including alcohol use disorder (AUD). An impaired ability to stop or control alcohol intake despite adverse health or social consequences characterize AUD. While AUDs predominantly occur in men, growing evidence suggests the existence of distinct cognitive and biological consequences of alcohol dependence in women. The molecular and physiological mechanisms participating in these differential effects remain unknown. Transcriptomic technology permits the detection of the biological mechanisms responsible for such sex-based differences, which supports the subsequent development of novel personalized therapeutics to treat AUD. We conducted a systematic review and meta-analysis of transcriptomics studies regarding alcohol dependence in humans with representation from both sexes. For each study, we processed and analyzed transcriptomic data to obtain a functional profile of pathways and biological functions and then integrated the resulting data by meta-analysis to characterize any sex-based transcriptomic differences associated with AUD. Global results of the transcriptomic analysis revealed the association of decreased tissue regeneration, embryo malformations, altered intracellular transport, and increased rate of RNA and protein replacement with female AUD patients. Meanwhile, our analysis indicated that increased inflammatory response and blood pressure and a reduction in DNA repair capabilities are associated with male AUD patients. In summary, our functional meta-analysis of transcriptomic studies provides evidence for differential biological mechanisms of AUD patients of differing sex.

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Section: Discussionmentioning

confidence: 99%

Unveiling Sex-Based Differences in the Effects of Alcohol Abuse: A Comprehensive Functional Meta-Analysis of Transcriptomic Studies

Ferrer

Pascual

Hidalgo

et al. 2020

Genes

View full text Add to dashboard Cite

show abstract

“…For instance, we discovered increased activity and migration of several cell types related to the innate immune response in male AUD patients. This increase might relate to an augmented response upon the presence of pathogens and inflammation, and studies have related an increased inflammatory response to AUD [50,51], which might be related to a decrease in the production of tumor necrosis factor-alpha. However, the inna te immune response may be depressed in female AUD patients, making them more vulnerable to infections.…”

Section: Discussionmentioning

confidence: 99%

Unveiling sex-based differences in the effects of alcohol abuse: a comprehensive functional meta-analysis of transcriptomic studies

Ferrer

Pascual

Hidalgo

et al. 2020

Preprint

View full text Add to dashboard Cite

The abuse of alcohol, one of the most popular psychoactive substances, can cause several pathological and psychological consequences, including alcohol use disorder (AUD). An impaired ability to stop or control alcohol intake despite adverse health or social consequences characterize AUD. While AUDs predominantly occur in men, growing evidence suggests the existence of distinct cognitive and biological consequences of alcohol dependence in women. The molecular and physiological mechanisms participating in these differential effects remain unknown. Transcriptomic technology permits the detection of the biological mechanisms responsible for such sex-based differences, which supports the subsequent development of novel personalized therapeutics to treat AUD. We conducted a systematic review and meta-analysis of transcriptomics studies regarding alcohol dependence in humans with representation from both sexes. For each study, we processed and analyzed transcriptomic data to obtain a functional profile of pathways and biological functions and then integrated the resulting data by meta-analysis to characterize any sex-based transcriptomic differences associated with AUD. Global results of the transcriptomic analysis revealed the association of decreased tissue regeneration, embryo malformations, altered intracellular transport, and increased rate of RNA and protein replacement with female AUD patients. Meanwhile, our analysis indicated that increased inflammatory response and blood pressure and a reduction in DNA repair capabilities associated with male AUD patients. In summary, our functional meta-analysis of transcriptomic studies provides evidence for differential biological mechanisms that AUD patients of differing sex.

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“…Further adduct creation intensifies the process of creating antibodies as well as the inflammation and oxidative stress, which causes hepatocyte necrosis and deepens the process of liver fibrosis [22]. An example might be the occurrence of acetaldehyde adducts with plasma albumin [28] or erythrocytes [29], which may be employed as markers of excessive alcohol consumption. The quantitative marking of adducts with collagen may also reflect the degree of liver damage though these adducts may lead to damage to that organ [30].…”

Section: Oddziaływanie Na Wątrobę Adduktów Aldehydu Octowego Z Innymimentioning

confidence: 99%

“…Dalsze tworzenie adduktów nasila proces wytwarzania przeciwciał oraz stan zapalny i stres oksydacyjny, co powoduje martwicę hepatocytów i tym samym pogłębia proces włóknienia wątroby [22]. Przykładem może być powstawanie adduktów aldehydu octowego z albuminami surowicy [28] czy erytrocytów [29], które mogą być wykorzystywane jako markery nadmiernego spożywania etanolu. Ilościowe oznaczanie adduktów z kolagenem również może odzwierciedlać stopień uszkodzenia wątroby, choć te addukty mogą powodować uszkodzenia tego narządu [30].…”

Section: Oddziaływanie Na Wątrobę Adduktów Aldehydu Octowego Z Innymiunclassified

The effect of the products of ethanol metabolism on the liver – a review

Kołota¹

2018

ain

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The consequences of consuming excessive amounts of alcoholic beverages are currently an important problem for many societies, not only in the context of treatment of alcohol dependence, but also the health effects of alcohol abuse. Long-term consumption of alcoholic beverages is associated with increased risk of hypertension, ischemic heart disease, also mouth and throat, stomach, liver or large intestine cancer. Due to almost 90% of consumed alcohol being broken down in the liver by oxidative pathways, this organ is particularly vulnerable to the effects of alcohol metabolism. The consequences of alcohol metabolism in the liver is the formation of byproducts, namely acetaldehyde and interaction between acetaldehyde and proteins, lipoproteins, DNA, also formation of reactive oxygen species and markers of inflammation, which can intensify immunological and inflammatory reactions and oxidative stress, thus contributing to the damage of hepatocytes,

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Immune response to acetaldehyde-human serum albumin adduct among healthy subjects related to alcohol intake

Cited by 10 publications

References 30 publications

Unveiling Sex-Based Differences in the Effects of Alcohol Abuse: A Comprehensive Functional Meta-Analysis of Transcriptomic Studies

Unveiling Sex-Based Differences in the Effects of Alcohol Abuse: A Comprehensive Functional Meta-Analysis of Transcriptomic Studies

Unveiling sex-based differences in the effects of alcohol abuse: a comprehensive functional meta-analysis of transcriptomic studies

The effect of the products of ethanol metabolism on the liver – a review

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