Immune response to BCG-Moreau (Rio de Janeiro) strain. Spectrum of delayed hypersensitivity in genetically defined mice

Mortatti, Rodnei C.

doi:10.1016/0378-1097(89)90277-2

Cited by 1 publication

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References 9 publications

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“…Development of delayed-type hypersensitivity (DTH) to mycobacterial antigens differs among the mouse strains and relates to the H-2 loci: C57BL/6 (H-2 b ) as a high responder, BALB/c (H-2 d ) as an intermediate responder and C3H/HeN (H-2 k ) as a low responder. 24,25 Therefore, the difference in induction of hypersensitivity by TDM seems to reflect the difference in the development of DTH.…”

Section: Discussionmentioning

confidence: 99%

Induction of hypersensitivity to endotoxin lethality in mice by treatment with trehalose 6,6′-dimycolate but not with 2,3,6,6′-tetraacyl trehalose 2′-sulfate

Watanabe

Hasunuma

Horikoshi

et al. 1999

Journal of Endotoxin Research

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The mechanism by which priming with trehalose 6,6′-dimycolate (TDM, cord factor) induced hypersensitivity to endotoxin lethality was investigated. C57BL/6 and BALB/c mice primed with TDM succumbed to endotoxin shock, but BALB/c IFN-γ knock-out (IFN-γ —/—) mice showed resistance to LPS lethality. The levels of serum IFN-γ peaked on day 4 after priming with TDM and kept significant levels, indicating that IFN-γ plays a critical role for inducing hypersensitivity to LPS lethality. After challenge with LPS, TDM-primed mice produced higher amounts of serum TNFα and soluble CD14. A sulfolipid (SL, 2,3,6,6′-tetraacyl trehalose 2′-sulfate) did not induce the hypersensitivity and, conversely, suppressed the activity of TDM when administered together. Administration of TDM induced infiltration of mononuclear cells in liver, and apoptosis of cells present in the liver sinus was observed after LPS challenge. These results suggest that the hypersensitivity to LPS lethality is due to overproduction of cytokines and other molecules.

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Section: Discussionmentioning

confidence: 99%

Induction of hypersensitivity to endotoxin lethality in mice by treatment with trehalose 6,6′-dimycolate but not with 2,3,6,6′-tetraacyl trehalose 2′-sulfate

Watanabe

Hasunuma

Horikoshi

et al. 1999

Journal of Endotoxin Research

View full text Add to dashboard Cite

show abstract

Immune response to BCG-Moreau (Rio de Janeiro) strain. Spectrum of delayed hypersensitivity in genetically defined mice

Abstract: response of strains expressing Bcg (r) or (s) trait showed no relationship between the Bcg locus and DTH to mycobacteria. These data suggest DTH is under polygenic control including the major histocompatibility complex but excluding the Bcg locus. 0920-8534/89/$03.50

Cited by 1 publication

References 9 publications

Induction of hypersensitivity to endotoxin lethality in mice by treatment with trehalose 6,6′-dimycolate but not with 2,3,6,6′-tetraacyl trehalose 2′-sulfate

Induction of hypersensitivity to endotoxin lethality in mice by treatment with trehalose 6,6′-dimycolate but not with 2,3,6,6′-tetraacyl trehalose 2′-sulfate

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