Immune Response to Campylobacter Pyloridis in Patients With Peptic Ulceration

Kaldor, J.; Tee, Wee; McCarthy, P; Watson, Jan; Dwyer, Brian

doi:10.1016/s0140-6736(85)91687-3

Cited by 71 publications

(23 citation statements)

References 1 publication

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“…Their use is recommended for long-term follow-up after therapy aimed at eradication [50], [52][53][54][55][56], Sero logical detection of IgG or IgA antibodies against II. pylori has proved to be a useful tool in the diagnosis of H. pylori infection.…”

Section: Imon-invasive Techniquesmentioning

confidence: 99%

“…pylori has proved to be a useful tool in the diagnosis of H. pylori infection. Differ ent methods of antibody detection have been developed, including complement fixation tests [57], passive haemagglutination assays [58], enzyme-linked immunosorbent assays (ELISA) [52,59], and immunoblot techniques [60,61]. Detection o f//, pylori by means ofin situ DNA hybridization is a sophisticated method not yet available to most investiga tors [62], Currently, the IgG ELISA is the most common technique.…”

Section: Imon-invasive Techniquesmentioning

confidence: 99%

See 1 more Smart Citation

A Review of Diagnostic Techniques for <i>Helicobacter pylori </i>Infection

Loffeld¹,

Stobberingh²,

Arends

1993

Dig Dis

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The description of Helicobacter pylori and an understanding of its pathogenetic significance has been one of the major breakthroughs in gastroenterology in the past decade. Because of the possible implications, a correct diagnosis of the infection is mandatory. Diagnostic techniques can be divided into invasive and non-invasive methods. The first require upper gastrointestinal endoscopy with a biopsy taken from the stomach. These biopsy specimens can be studied for the presence of H. pylori using several histological staining techniques, or culture. In addition, urease tests are possible. The non-invasive techniques do not require endoscopy. They comprise testing for the presence of antibodies against H. pylori in the patient’s serum, or breath tests with ¹³C- or ¹⁴C-labelled urea. In experienced hands every test has good sensitivity and specificity, and the test to be applied depends on local preference and experience.

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Section: Imon-invasive Techniquesmentioning

confidence: 99%

Section: Imon-invasive Techniquesmentioning

confidence: 99%

A Review of Diagnostic Techniques for <i>Helicobacter pylori </i>Infection

Loffeld¹,

Stobberingh²,

Arends

1993

Dig Dis

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“…The other arguments for the pathogenicity of this bacterial species are (i) an increase in antibody levels against C. pyloridis antigens in patients with C. pyloridis (2,6,11) and (ii) the development of the disease after an experimental inoculation with C. pyloridis of a volunteer (10). Further proof of this association could be generated from a clinical trial with antibiotics versus placebo.…”

mentioning

confidence: 99%

Susceptibility of Campylobacter pyloridis to 20 antimicrobial agents

Lambert¹,

Mégraud²,

Gerbaud³

et al. 1986

Antimicrob Agents Chemother

106

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“…Other evidence supporting a causative role for the organism in gastritis is that serum (7,37,55,57,58,108,132) and local (108,135) antibodies are produced by the host and the bacteria appear to attract and be ingested by polymorphonuclear leukocytes (S. Shousha, T. B. Bull, and R. A. Parkins, Letter, Lancet ii: 101,1984).…”

Section: Gastritismentioning

confidence: 99%

“…Further confirmation can be obtained, if desired, by using a system to detect preformed enzymes (84,87 (17) and a solution with a high concentration of urea and a pH indicator (46). One of the most widely used methods is a gel pellet containing urea and pH indicator (CLO-test; Delta West, Ltd., Canning Vale, Western Australia) (8,81 (7,15,37,55,57,58,92,108,131,132). Although several different immunological techniques have been used, the majority of workers have utilized an enzyme-linked immunosorbent assay.…”

Section: Laboratory Diagnosismentioning

confidence: 99%

Campylobacter pylori and gastroduodenal disease

Buck

1990

Clin Microbiol Rev

139

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Campylobacter pylori is a newly described, spiral-shaped, gram-negative bacillus that is oxidase positive, catalase positive, and urease positive and grows slowly in culture. Although observed in human tissue at the beginning of the century, it was not cultured until 1982. Because there are significant morphological and genetic differences between this organism and other species of Campylobacter, it will probably be reclassified in a new genus. Current information indicates that the organism primarily resides in the stomach tissue of humans and nonhuman primates and may occasionally spread to the esophagus or other parts of the alimentary tract under appropriate conditions. Significant evidence has accumulated in the last several years to show that it causes gastritis, and there is mounting evidence that it may participate in the development of duodenal ulcers. It may also be associated with gastric ulcers and nonulcer dyspepsia. It can be detected in patients by culture of biopsy specimens or histological staining of biopsy tissue. Indirect evidence for the presence of the organism can be obtained by detection of urease in a tissue biopsy specimen, by urea breath tests, or by detection of specific antibody. It may not be necessary to implement these procedures for routine use, however, until the role of the organism can be defined better. Ultimately, the discovery of this organism may lead to radical changes in the diagnosis and treatment of gastric disease.

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Immune Response to Campylobacter Pyloridis in Patients With Peptic Ulceration

Cited by 71 publications

References 1 publication

A Review of Diagnostic Techniques for <i>Helicobacter pylori </i>Infection

A Review of Diagnostic Techniques for <i>Helicobacter pylori </i>Infection

Susceptibility of Campylobacter pyloridis to 20 antimicrobial agents

Campylobacter pylori and gastroduodenal disease

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