Immune response to Plasmodium falciparum antigens in Cameroonian primigravidae: evolution after delivery and during second pregnancy

Fiévet, Nadine; Cot, Michel; Ringwald, Pascal; Bickii, Jean; Dubois, Betty Lou; Hesran, Jean-Yves Le; Migot, Florence; Deloron, Philippe

doi:10.1046/j.1365-2249.1997.d01-966.x

Cited by 33 publications

(37 citation statements)

References 21 publications

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“…However, our findings confirm previous reports from Cameroon 11,12,13 and Mozambique 10 showing that levels of IgG antibodies (with the exception of IgG4) against P. falciparum antigen not specifically associated with pregnancy increase with parity. The correlation observed between antibody levels and parity can be explain by the fact that mothers of higher parities were older in age and consequently may produce higher levels of IgG antibodies due to age-dependent immunity.…”

supporting

confidence: 91%

“…Studies have shown that the responses for both non-VSA-PAM 13,14 and VSAPAM [10][11][12][13][14][15] are dominated by the cytophilic subclass IgG1, followed by IgG3 consistent with data obtained from non-pregnant adults and children 14,16,17 . The predominance of IgG1 and IgG3 cytophilic antibody in endemic areas has been associated with either lower parasitaemia 18 or a lower risk of malaria attack 19 .…”

Section: Introductionsupporting

confidence: 75%

“…Thus placental P. falciparum infection has been associated with increased IgG levels against merozoite antigens and parasite isolates from pregnant and non-pregnant hosts 10 . Furthermore antibodies against P. falciparum antigens not specifically associated with pregnancy have also been shown to increase with parity [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

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IgG isotypic antibodies to crude Plasmodium falciparum blood-stage antigen associated with placental malaria infection in parturient Cameroonian women

et al. 2017

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Background: Few studies have reported an association between placental malaria (PM) infection and levels of isotypic antibodies against non-pregnancy associated antigens. Objective: To determine and evaluate IgG isotypic antibody levels to crude P. falciparum blood stage in women with and without PM infection. Methods: Levels of IgG (IgG1-IgG4) and IgM to crude P. falciparum blood stage antigen were measured by ELISA in 271 parturient women. Placental malaria infection was determined by placental blood microscopy and placental histology. Age, parity and intermittent preventive treatment during pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) usage were considered during analysis. Results: P. falciparum-specific IgG1 (96.5%) and IgG3 (96.7%) antibodies were predominant compared with IgG2 (64.6%) and IgG4 (49.1%). Active PM infection was associated with significant increased levels of IgG1, IgG4 and IgM while lower levels of these antibodies were associated with uptake of two or more IPTp-SP doses. PM infection was the only independent factor associated with IgG4 levels. Mean IgG1 + IgG3/IgG2 + IgG4 and IgG1 + IgG2 +IgG3/ IgG4 ratios were higher among the PM-uninfected group while IgG4/IgG2 ratio prevailed in the infected group. Conclusion: PM infection and IPTp-SP dosage influenced P. falciparum-specific isotypic antibody responses to blood stage antigens. An increase in IgG4 levels in response to PM infection is of particular interest.

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supporting

confidence: 91%

Section: Introductionsupporting

confidence: 75%

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IgG isotypic antibodies to crude Plasmodium falciparum blood-stage antigen associated with placental malaria infection in parturient Cameroonian women

et al. 2017

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“…In light of these experimental findings, it has been suggested that VAR2CSA may constitute an attractive target for vaccination against malaria in pregnancy. However, antibodies against P. falciparum antigens not specifically associated with pregnancy have also been shown to increase with parity (12,19,34,38). Moreover, a significant number of women at delivery have antibodies against placental parasites, but their placentas remain infected (22,44), and several studies have failed to show an association between levels of IgGs against CSAbinding IEs and a reduced frequency of adverse consequences of malaria during pregnancy (14,20,48).…”

mentioning

confidence: 99%

Parity and Placental Infection Affect Antibody Responses againstPlasmodium falciparumduring Pregnancy

et al. 2011

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Women are at higher risk of Plasmodium falciparum infection when pregnant. The decreasing risk of malaria with subsequent pregnancies is attributed to parity-dependent acquisition of antibodies against placental parasites expressing variant surface antigens, VAR2CSA, that mediate placental sequestration through adhesion to chondroitin sulfate A (CSA). However, modulation of immunity during pregnancy may also contribute to increase the risk of malaria. We compared antibody responses among 30 Mozambican primigravidae and 60 multigravidae at delivery, 40 men, and 40 children. IgG levels were measured against the surface antigens of erythrocytes infected with P. falciparum isolated from 12 pregnant women (4 placental and 8 peripheral blood isolates) and 26 nonpregnant hosts. We also measured IgG levels against merozoite recombinant antigens and total IgG. Placental P. falciparum infection was associated with increased levels of total IgG as well as IgG levels against merozoite antigens and parasite isolates from pregnant and nonpregnant hosts. We therefore stratified comparisons of antibody levels by placental infection. Compared to multigravidae, uninfected primigravidae had lower total IgG as well as lower levels of IgGs against peripheral blood isolates from both pregnant and nonpregnant hosts. These differences were not explained by use of bed nets, season at delivery, neighborhood of residence, or age. Compared to men, infected primigravidae had higher levels of IgGs against isolates from pregnant women and CSA-binding lines but not against other isolates, supporting the concept of a pregnancyspecific development of immunity to these parasite variants. Results of this study show that parity and placental infection can modulate immune responses during pregnancy against malaria parasites.

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“…Studies of toxoplasmosis and malaria have associated cytokine responses with susceptibility to congenital and placental infection in mice and humans, respectively (11,14,(22)(23)(24). The role of IL-4 in the regulation of congenital protozoal disease is controversial.…”

mentioning

confidence: 99%

Neutralization of Maternal IL-4 Modulates Congenital Protozoal Transmission: Comparison of Innate Versus Acquired Immune Responses

Long

Baszler

2000

The Journal of Immunology

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IL-4 levels were modulated in mice to test the hypothesis that induction of a maternal type 1 response would decrease the frequency of congenital Neospora caninum transmission. This hypothesis tested the relationship between IL-4 and both innate and adaptive immunity utilizing two basic experimental designs. In the first, maternal IL-4 was neutralized with mAb during pregnancy in naive mice concomitant with initial, virulent infection. In the second, maternal IL-4 was neutralized before pregnancy concomitant with a priming inoculation consisting of live, avirulent N. caninum tachyzoites followed by virulent challenge during subsequent gestation. In mice that were naive before pregnancy, neutralization of IL-4 during gestational challenge did not result in decreased congenital transmission as measured by PCR performed on 1-day-old neonatal mice. In mice that were primed and modulated before pregnancy, congenital transmission from gestational challenge was significantly decreased compared with control mice. Reduction in transmission constituted a decrease in the numbers of mice transmitting N. caninum and a lower frequency of transmission by individual dams (p < 0.05). Decreased congenital transmission was associated with significantly lower levels of maternal splenocyte IL-4 secretion, lower IL-4 mRNA levels, and higher levels of IFN-γ secretion. Protected mice had significantly decreased Neospora-specific IgG1 compared with nonmodulated mice. These studies define a relationship between maternal Ag-specific immunity and the frequency of congenital transmission and demonstrate that modulation of type 2 cytokine responses can change the frequency of congenital protozoal transmission.

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Immune response to Plasmodium falciparum antigens in Cameroonian primigravidae: evolution after delivery and during second pregnancy

Cited by 33 publications

References 21 publications

IgG isotypic antibodies to crude <i>Plasmodium falciparum</i> blood-stage antigen associated with placental malaria infection in parturient Cameroonian women

IgG isotypic antibodies to crude <i>Plasmodium falciparum</i> blood-stage antigen associated with placental malaria infection in parturient Cameroonian women

Parity and Placental Infection Affect Antibody Responses againstPlasmodium falciparumduring Pregnancy

Neutralization of Maternal IL-4 Modulates Congenital Protozoal Transmission: Comparison of Innate Versus Acquired Immune Responses

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