Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program

Abstract

A non-controlled longitudinal study was conducted to evaluate the combined vaccine against measles, mumps and rubella (MMR) immunogenicity in 150 children vaccinated in the routine of three health units in the city of Rio de Janeiro, Brazil, 2008-2009, without other vaccines administered during the period from 30 days before to 30 days after vaccination. A previous study conducted in Brazil in 2007, in 1,769 children ranging from 12-15 months of age vaccinated against yellow fever and MMR simultaneously or at intervals of 30 days or more between doses, had shown low seroconversion for mumps regardless of the interval between administration of the two vaccines. The current study showed 89.5% (95% confidence interval: 83.3; 94.0) seroconversion rate for mumps. All children seroconverted for measles and rubella. After revaccination, high antibody titres and seroconversion rates were achieved against mumps. The results of this study and others suggest that two MMR doses confer optimal immunoresponses for all three antigens and the possible need for additional doses should be studied taking into account not only serological, but also epidemiological data, as there is no serological correlate of protection for mumps.

Immunogenicity and safety of the combined vaccine for measles, mumps, and rubella isolated or combined with the varicella component administered at 3-month intervals: randomised study

“…The seroconversion rates for measles and rubella following the MMR vaccine were similar to those reported in previous studies 2 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 A smaller seroconversion for mumps was expected, in relation to measles and rubella, according to similar findings from other studies 2 …”

“…The geometric mean titres of MMR were similar to those of previous studies that used the same methodology to evaluate immunogenicity 2 4 , 9 , 10 , 11 , 13 , 14 , 15 , 16 , 17 , 19 , 20 The magnitude of the increase in the proportion of seropositives and GMT of antibodies for mumps after the second dose was much higher than that for measles and rubella, which is consistent with that observed in previous studies 2 …”

“…Sample size - To calculate the sample size, the results of the immunogenicity used as reference were obtained in previous studies on combined MMR vaccines 2 4 ) For a more conservative sample size calculation, the mean seropositivity for mumps was used as reference, as it was the antigen with the lowest immunogenicity.…”

“…The use of two doses of MMR vaccine, or MMR vaccine followed by MMRV vaccine, increases the levels of antibody titres and enables high seroconversion for MMR, virtually eliminating primary failures and maintaining the levels of antibody titres for a prolonged period of time 2 …”

Produção De Cepas Vacinais Do Vírus Da Caxumba: Uma Revisão De Literatura

“…As vacinas baseadas na cepa Jeryl Lynn são as mais seguras, pois causam menores taxas de meningite asséptica, principal efeito colateral das vacinas contra a caxumba (19,20).…”