Immune responses in adults to revaccination with a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine 10 years after a previous dose

Halperin, Scott A.; Scheifele, David W.; Serres, Gaston De; Noya, Francisco; Meekison, William; Zickler, Paul; Larrivée, Luc; Langley, Joanne M.; McNeil, Shelly; Dobson, Simon; Jordanov, Emilia; Thakur, Manoj Kumar; Decker, Michael D.; Johnson, David R.

doi:10.1016/j.vaccine.2011.11.035

Cited by 45 publications

(16 citation statements)

References 36 publications

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“…Among other potential causes of this phenomenon, the waning of the immunity conferred by the existing vaccine has been discussed. Indeed, Bordetella pertussis -specific antibodies decline significantly over 5-10 years after vaccination, and data exist showing that booster doses of combined diphtheria-tetanus-pertussis vaccine are very well tolerated and immunogenic when given periodically to adults and to older subjects [47]. …”

Section: Towards a Comprehensive Approach To Vaccination Of The Elderlymentioning

confidence: 99%

Vaccines for the Elderly

Giudice

Weinberger²,

Grubeck‐Loebenstein³

2014

Gerontology

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The aging of the human population is posing serious challenges to research and to public health authorities in order to prevent diseases that more frequently affect the elderly, a portion of the population that will increase more and more in the coming years. While some vaccines exist and are used in the elderly to effectively fight against some infections (e.g. influenza, pneumococci, varicella-zoster virus, diphtheria, and tetanus), still a lot of work remains to be done to better adapt these vaccines and to develop new ones for this age group. The prevention of infectious diseases affecting the elderly can be successful only through a holistic approach. This approach will aim at the following: (1) a deeper understanding of the mechanisms leading to the senescence of the immune system, (2) a better and broader use of vaccines recommended for the elderly, (3) the use of vaccines currently considered only for other age groups and (4) actively priming the population when they are immunological competent, before the physiological waning of immune responsiveness may affect the beneficial effects of vaccination.

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Section: Towards a Comprehensive Approach To Vaccination Of The Elderlymentioning

confidence: 99%

Vaccines for the Elderly

Giudice

Weinberger²,

Grubeck‐Loebenstein³

2014

Gerontology

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“…The Tdap and Tdap-IPV vaccines recommended for HCPs are safe and their reactogenicity profile is similar to that of the dT and dT-IPV vaccines 7,8,9,16,29,100,101,102,103,104,107,108,109,110,111,112,113,114,115,116,117,118,119,120 . Fewer local reactions were reported among Tdap or Tdap-IPV recipients compared with those who received Tdap or Tdap-IPV.…”

Section: The Main Issues Associated With the Tdap And Tdap-ipv Vaccinesmentioning

confidence: 84%

“…Recent studies confirmed that a dTpa vaccine can be given 5 to 10 years after the previous dose in adults immunized with the same product 117,118,119 .…”

Section: The Main Issues Associated With the Tdap And Tdap-ipv Vaccinesmentioning

confidence: 93%

“…It is estimated that protection lasts for 5 to 10 years 110,111,112,113,117,118,119 ; however, until now, only a few countries recommend redosing of these vaccines 31 . Recent studies confirmed that a dTpa vaccine can be given 5 to 10 years after the previous dose in adults immunized with the same product 117,118,119 .…”

Section: The Main Issues Associated With the Tdap And Tdap-ipv Vaccinesmentioning

confidence: 99%

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Should acellular pertussis vaccine be recommended to healthcare professionals?

Moraes¹,

Carvalhanas

Bricks³

2013

Cad. Saúde Pública

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The aim of this study was to describe recent changes in the epidemiology of pertussis and existing policies regarding recommended and mandatory occupational vaccinations for healthcare professionals (HCPs). The authors carried out an extensive review of references on the PubMed and SciELO databases and the official sites of the World Health Organization, Pan American Health Organization, Centers for Disease Control and Prevention, and Brazilian Ministry of Health, using the keywords pertussis, vaccines and healthcare professionals. Vaccination against pertussis is recommended for HCPs in the United States, Canada, nine European countries, Australia, Hong Kong, Singapore, Costa Rica, Argentina and Uruguay, and in some countries it is compulsory. In Brazil, only one publication discussing the risk of pertussis among HCPs was found. Considering the reemergence of pertussis and the great number of associated hospitalizations and deaths registered in 2011, it is necessary to review public policies regarding HCP pertussis vaccination, particularly among workers in frequent contact with young babies.

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“…Limited data are available regarding the safety of repeated Tdap vaccination. In adults and adolescents who had received Tdap as part of Tdap licensure trials, 4 studies did not find an elevated risk of local or systemic reactions to a second dose of Tdap, compared either with Tdap‐naïve subjects or with subjects receiving a dose of tetanus toxoid and reduced diphtheria toxoid (Td) vaccine alone . However, these studies were small (between 82 and 769 subjects) and unable to evaluate rare adverse events.…”

Section: Introductionmentioning

confidence: 99%

Safety of repeated doses of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine in adults and adolescents

Jackson

Nelson

et al. 2018

Pharmacoepidemiology and Drug

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In light of waning immunity to pertussis following receipt of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine, maintaining protection may require repeated Tdap vaccination. We evaluated the safety of repeated doses of tetanus-containing vaccine in 68 915 nonpregnant adolescents and adults in the Vaccine Safety Datalink population who had received an initial dose of Tdap. Compared with 7521 subjects who received a subsequent dose of tetanus toxoid, reduced diphtheria (Td) vaccine, the 61 394 subjects who received a subsequent dose of Tdap did not have significantly elevated risk of medical visits for seizure, cranial nerve disorders, limb swelling, pain in limb, cellulitis, paralytic syndromes, or encephalopathy/encephalitis/meningitis. These results suggest that repeated Tdap vaccination has acceptable safety relative to Tdap vaccination followed by Td vaccination.

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Immune responses in adults to revaccination with a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine 10 years after a previous dose

Cited by 45 publications

References 36 publications

Vaccines for the Elderly

Vaccines for the Elderly

Should acellular pertussis vaccine be recommended to healthcare professionals?

Safety of repeated doses of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine in adults and adolescents

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