Immune responses in lung cancer patients measured by a modified leukocyte adherence inhibition test using serum

Sanner, Tore; Kotlar, Hans Kristian; Eker, Per

doi:10.1016/0304-3835(80)90143-3

Cited by 25 publications

(14 citation statements)

References 7 publications

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“…Although the H-LAI test was essentially performed with the technique of Sanner et al [22], the procedure we used will be detailed because of some important modifications.…”

Section: Methodsmentioning

confidence: 99%

“…Although promising results with the humoral LAI (H-LAI) assay in breast and lung cancer have been published [16,22], histological specificity has not yet been well documented. In this study we examined the problem of whether lung cancers possessed histologic ally specific neoantigens or whether there were com mon organ-related antigens that caused cross reactivities.…”

Section: Introductionmentioning

confidence: 99%

“…Sanner et al [22] have recently de veloped a modified LAI assay in which serum is added in combination with relevant antigens. The immune complexes formed in vitro bind to Fc receptors of the trypsinized leukocytes.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Humoral Leukocyte Adherence Inhibition in the Discrimination among Histologic Types of Lung Cancer

1983

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In an attempt to differentiate among histologic types of lung cancer, a modified humoral leukocyte adherence inhibition (H-LAI) assay was used. All types of lung cancer gave positive H-LAI indices against both homologous and autologous tumor extracts of the relevant histologic types. Positive H-LAI values were obtained even with unrelated tumor extracts. Cross-reactivity suggests that common antigen determinants or antigens of broad specificity play a role in the H-LAI assay.

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“…Although the H-LAI test was essentially performed with the technique of Sanner et al [22], the procedure we used will be detailed because of some important modifications.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Humoral Leukocyte Adherence Inhibition in the Discrimination among Histologic Types of Lung Cancer

1983

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“…Due to this pro perty of cells, the cellular leukocyte adherence inhibi tion (C-LAI) and humoral leukocyte adherence in hibition (H-LA1) tests were developed to study cellmediated or humoral immunoactivity during the ma lignant process [1][2][3]. It seems that the H-LAI tech nique being as effective as the C-LAI possesses further advantages.…”

Section: Introductionmentioning

confidence: 99%

Modified Humoral Leukocyte Adherence Inhibition Test for Detection of Lung Cancer

Kubasova

Horváth²,

Szarvas³

et al. 1989

Oncology

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The freshly separated indicator cells (suspension of leukocytes) used in humoral leukocyte adherence inhibition test were labeled either with ¹⁴C-amino acid mixture or ³H-concanavalin A (³H-ConA). Instead of counting the adherent cells, the amount of ‘adherent’ radioactivity was measured by a liquid scintillation spectrometer. By the modified method, sera from 25 lung-carcinoma-bearing patients as well as serum samples from 21 healthy persons were examined in the presence of crude antigens prepared from ‘normal’ lung tissue or lung tumors of various histologic types. Although the results demonstrated high specificity and reproducibility of both methods, the binding of ³H-ConA to the surface of adherent cells is more expressed and assures higher levels of radioactivity.

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“…The humoral leukocyte adherence inhibition (H-LAI) test described by Sanner et al [3] and modified by us [1] was applied in lung cancer. It proved to be useful with high specificity [2] to differentiate human serum albumin from normal lung tissue and lung tumor tissue antigen.…”

Section: Introductionmentioning

confidence: 99%

The Humoral Leukocyte Adherence Inhibition Test in the Investigation of Lung Cancer Treated by Surgery and Radiotherapy

et al. 1985

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17 operable and 13 inoperable lung cancer patients entered the study. In all patients, the humoral leukocyte adherence inhibition (H-LAI) test was positive before treatment. 7–20 days after surgery the H-LAI values decreased to normal levels in 8/8 cases. On radiotherapy, the same decrease was valid in 7/9 patients. Two exceptions in which no H-LAI reduction could be observed were in correlation with tumor progression.

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Immune responses in lung cancer patients measured by a modified leukocyte adherence inhibition test using serum

Cited by 25 publications

References 7 publications

The Humoral Leukocyte Adherence Inhibition in the Discrimination among Histologic Types of Lung Cancer

The Humoral Leukocyte Adherence Inhibition in the Discrimination among Histologic Types of Lung Cancer

Modified Humoral Leukocyte Adherence Inhibition Test for Detection of Lung Cancer

The Humoral Leukocyte Adherence Inhibition Test in the Investigation of Lung Cancer Treated by Surgery and Radiotherapy

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