Immune Responses on Activation of Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Mice with Depression-Like States

Идова, Г. В.; Yuriev, D. V.; Кузнецова, С.М.

doi:10.1007/s11055-012-9567-1

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“…An important role of pre-and postsynaptic 5-HT 1A receptors in the immune response control has been shown not only in normal, but also in mice and rats displaying either depressive-like behavior or increased aggressiveness [14] [16] [18]- [21]. It has also been reported that activation of 5-HT 2A receptors, localized only postsynaptically, with their preferential agonist DOI resulted in a decrease of the rosette-forming cell numbers and cytotoxic/suppressor CD8 + T lymphocytes in the spleen of mice [15], as well as in the proliferative activity of T lymphocytes in rats [13].…”

Section: Introductionmentioning

confidence: 99%

Role of 5-HT2A Receptors in Immunomodulation in Animal Models of Aggressive Behavior

Идова¹,

Альперина²,

Жукова³

et al. 2016

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Serotonin 5-HT2A receptors are playing an important role in the pathophysiology of aggressive behaviors and in the control of immune function. In the present study, we analyzed the effects of activation and blockade of 5-HT2A receptors with selective ligands on the immune response formation in animals with aggressive behaviors induced by genetic factors (rats selected for the increased aggressiveness toward human) or by chronic social stress (mice of the CBA/Lac strain engaged in 10 days of social confrontations). Activation of 5-HT2A receptors with DOI at 1.0 mg/kg reduced the immune response level both in aggressive rats and mice compared to the corresponding vehicle-treated groups, while DOI administration did not alter the immune reaction in nonaggressive animals. The blockade of 5-HT2A receptors with ketanserin at 1.0 mg/kg resulted in immunostimulation both in mice of the CBA strain not subjected to social stress (the controls) and in nonaggressive rats selected for elimination of aggressiveness. On the other hand, its administration to CBA mice demonstrating offensive aggression enhanced the immune reaction, while the same dose of ketanserin did not modify the immune response level in rats with genetic predisposition to the increased defensive aggression. Thus, our data suggest that the role of 5-HT2A receptors in immunomodulation depends on the specific type of aggression that may be taking into account in the treatment of some neuropsychiatric disorders with the antipsychotic drugs and antidepressants targeting 5-HT2A receptors.

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