Immune responses to <i><scp>S</scp>chistosoma haematobium</i> infection

Odegaard, Justin I.; Hsieh, Michael H.

doi:10.1111/pim.12084

Cited by 27 publications

(26 citation statements)

References 98 publications

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“…The present study reported different proportions of AEs comparable to those found in other studies involving praziquantel and / or albendazole. However, there are variations that may occur due to the heterogeneous antecedents of the participating individuals, such as age, nutritional and immunological status, socioeconomic conditions, environmental exposure, prevalence and intensity of infection, stage of parasite development, etc [13,18,20,21,[31][32][33][34][35][36][37]. Zwang et al reviewed the efficacy and safety of PZQ (40mg/kg), and report that the main AEs experienced and their incidences are mainly abdominal pain (31.8%), muscle pain (29.2%), joint pain (20.2%), headache (13.6%), diarrhoea (12.9%), fatigue (9.6%), nausea (10.6%), dizziness (11.9%), vomiting (7.9%) and itching (9.8%) [18].…”

Section: Discussionmentioning

confidence: 99%

Schistosomiasis and soil-transmitted helminthiasis preventive chemotherapy: Adverse events in children from 2 to 15 years in Bengo province, Angola

et al. 2020

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Preventive chemotherapy campaigns with praziquantel and albendazole are being implemented in Angola, as a high priority public health intervention. However, there are no published data regarding adverse events associated with these medications. In this context, we analysed adverse events due to co-administration of praziquantel and albendazole in endemic areas of schistosomiasis and soil-transmitted helminths in Bengo, Angola. In the context of a targeted drug administration, between December 2012 and September 2013, we conducted two surveys after co-administrating single oral doses of praziquantel and albendazole tablets to children 2 to 15 years of age. About 24 hours after each treatment, participants answered a questionnaire about adverse events. At baseline, 605 children (55.0% male; mean age: 9.7 years) were treated; 460 were interviewed and 257 (55.9%) reported at least one adverse event, 62.3% (160/257) of children being infected with schistosoma haematobium. After six months of treatment, among 339 children surveyed, 184 (54.3%) reported adverse events, with 49.5% (91/184) of infected children. Adverse events were most common in preschoolaged children, with no significant difference between genders. The most frequent adverse events in the two surveys were abdominal pain (18.5%, 25.7%), headache (20.9%, 23.0%) and dizziness (15.7%, 19.8%). Children aged 12 to 15 years (adjusted OR = 0.40, p = 0.040) and those with mixed infection (adjusted OR = 0.04, p = 0.011) had lower odds of adverse events. After the second treatment, those with heavy infection (adjusted OR = 2.72, p = 0.018) and aged 9-11 years (adjusted OR = 2.01, p = 0.049) had significantly fewer adverse events. About 2.0% of children experienced severe adverse events. This study adds evidence that preventive chemotherapy for schistosomiasis and soil-transmitted helminths control is safe, but cases of adverse events are expected. Standardized methodologies to discriminate drug-related adverse events from the clinical manifestations of the infections are needed.

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Section: Discussionmentioning

confidence: 99%

Schistosomiasis and soil-transmitted helminthiasis preventive chemotherapy: Adverse events in children from 2 to 15 years in Bengo province, Angola

et al. 2020

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“…The trematode Schistosoma haematobium ( S. haematobium ) is an exemplary case of parasite-induced inflammation and cancer, specifically bladder SCC (BSCC) (Odegaard and Hsieh, 2014). Following S. haematobium infection of the urinary tract, primary tumors usually develop in the bladder wall, within the fibrotic granuloma tissue that forms around the parasitic eggs (Odegaard and Hsieh, 2014).…”

Section: Etiology Of Sccsmentioning

confidence: 99%

“…Following S. haematobium infection of the urinary tract, primary tumors usually develop in the bladder wall, within the fibrotic granuloma tissue that forms around the parasitic eggs (Odegaard and Hsieh, 2014). Chronic inflammation is thought to cause metaplasia of the transitional urothelium into squamous tissue before an accumulation of oncogenic mutations that culminate in uncontrolled cell growth.…”

Section: Etiology Of Sccsmentioning

confidence: 99%

Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

2016

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SUMMARY Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and a major cause of cancer mortality. These highly heterogeneous tumors arise from closely interconnected epithelial cell populations with intrinsic self-renewal potential inversely related to the stratified differentiation program. SCCs can also originate from simple or pseudo-stratified epithelia through activation of quiescent cells and/or a switch in cell fate determination. Here, we focus on specific determinants implicated in the development of SCCs by recent large-scale genomic, genetic and epigenetic studies and complementary functional analysis. This evidence indicates that SCCs from various body sites, while clinically treated as separate entities, have common determinants, pointing to a unified perspective of the disease and potential new avenues for prevention and treatment.

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“…In longitudinal studies, antibody responses to specific schistosome antigens have been shown to correlate with resistance to reinfection . Generally, the antibody responses associated with human resistance to reinfection are directed against the schistosome adult worm and not egg antigens . This finding may not be surprising as the immune responses to crude adult worm and egg antigens have been widely studied.…”

Section: Discussionmentioning

confidence: 99%

“…60,61 Generally, the antibody responses associated with human resistance to reinfection are directed against the schistosome adult worm and not egg antigens. 62 This finding may not be surprising as the immune responses to crude adult worm and egg antigens have been widely studied. However, limited work has shown that IgG 32 and IgE 31 antibody responses to larval antigens are associated with resistance to reinfection.…”

Section: Discussionmentioning

confidence: 99%

Antibody responses to Schistosoma mansoni schistosomula antigens

Egesa

Lubyayi

Jones

et al. 2018

Parasite Immunology

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Summary While antigens from Schistosoma schistosomula have been suggested as potential vaccine candidates, the association between antibody responses with schistosomula antigens and infection intensity at reinfection is not well known. Schistosoma mansoni ‐infected individuals were recruited from a schistosomiasis endemic area in Uganda (n = 372), treated with 40 mg/kg praziquantel ( PZQ ) and followed up at five weeks and at one year post‐treatment. Pre‐treatment and five weeks post‐treatment immunoglobulin (Ig) E, IgG1 and IgG4 levels against recombinant schistosomula antigens rSmKK 7, rSmL y6A, rSmL y6B and rSmTSP 7 were measured using ELISA . Factors associated with detectable pre‐treatment or post‐treatment antibody response against the schistosomula antigens and the association between five‐week antibody responses and one year post‐treatment reinfection intensity among antibody responders were examined. Being male was associated with higher pre‐treatment IgG1 to rSmKK 7, rSmL y6a and AWA . Five weeks post‐treatment antibody responses against schistosomula antigens were not associated with one year post‐treatment reinfection intensity among antibody responders’ antibody levels against rSmKK 7, rSmL y6B and rSmTSP 7 dropped, but increased against rSmL y6A, AWA and SEA at five weeks post‐treatment among antibody responders. S. mansoni ‐infected individuals exhibit detectable antibody responses to schistosomula antigens that are affected by treatment. These findings indicate that schistosomula antigens induce highly varied antibody responses and could have implications for vaccine development.

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Immune responses to Schistosoma haematobium infection

Cited by 27 publications

References 98 publications

Schistosomiasis and soil-transmitted helminthiasis preventive chemotherapy: Adverse events in children from 2 to 15 years in Bengo province, Angola

Schistosomiasis and soil-transmitted helminthiasis preventive chemotherapy: Adverse events in children from 2 to 15 years in Bengo province, Angola

Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

Antibody responses to Schistosoma mansoni schistosomula antigens

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