Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials

Franz, Sandra; Rammelt, Stefan; Scharnweber, Dieter; Simon, Jan C.

doi:10.1016/j.biomaterials.2011.05.078

Cited by 1,203 publications

(1,138 citation statements)

References 249 publications

Supporting

Mentioning

1,109

Contrasting

Unclassified

Order By: Relevance

“…Biocompatibility of the constructs can be modified by chemical and architectural properties that modulate immune response and macrophage invasion. It has been reported that hydrophilic implants were generally better tolerated by the host [45]. Moreover, fibrous, parallel oriented substrates were shown to reduce pro-inflammatory cytokine production when compared to 2-D films or randomly oriented fibres of the same material [46].…”

Section: Discussionmentioning

confidence: 99%

Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization

et al. 2014

View full text Add to dashboard Cite

Cardiac tissue engineering approaches can deliver large numbers of cells to the damaged myocardium and have thus increasingly been considered as a possible curative treatment to counteract the high prevalence of progressive heart failure after myocardial infarction (MI). Optimal scaffold architecture and mechanical and chemical properties, as well as immune-and bio-compatibility, need to be addressed. We demonstrated that radio-frequency plasma surface functionalized electrospun poly (e-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation. Using a rat model of chronic MI, we showed that MSC-seeded plasma-coated PCL grafts stabilized cardiac function and attenuated dilatation. Significant relative decreases of 13% of the ejection fraction (EF) and 15% of the fractional shortening (FS) were observed in sham treated animals; respective decreases of 20% and 25% were measured 4 weeks after acellular patch implantation, whereas a steadied function was observed 4 weeks after MSC-patch implantation (relative decreases of 6% for both EF and FS).

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization

et al. 2014

View full text Add to dashboard Cite

show abstract

“…A favorable macrophage polarization can create an osteogenic microenvironment that improves osteogenesis, whereas an unfavorable macrophage polarization may exacerbate inflammation and destroy the tissue–biomaterial integration 12, 45. In general, the M2 macrophage phenotype accounts for antiinflammation and tissue regeneration, whereas the M1 macrophage phenotype is proinflammatory and causes tissue destruction.…”

Section: Discussionmentioning

confidence: 99%

Valence State Manipulation of Cerium Oxide Nanoparticles on a Titanium Surface for Modulating Cell Fate and Bone Formation

et al. 2017

View full text Add to dashboard Cite

Understanding cell–biomaterial interactions is critical for the control of cell fate for tissue engineering and regenerative medicine. Here, cerium oxide nanoparticles (CeONPs) are applied at different Ce4+/Ce3+ ratios (i.e., 0.46, 1.23, and 3.23) to titanium substrate surfaces by magnetron sputtering and vacuum annealing. Evaluation of the cytotoxicity of the modified surface to cultured rat bone marrow mesenchymal stem cells (BMSCs) reveals that the cytocompatibility and cell proliferation are proportional to the increases in Ce4+/Ce3+ ratio on titanium surface. The bone formation capability induced by these surface modified titanium alloys is evaluated by implanting various CeONP samples into the intramedullary cavity of rat femur for 8 weeks. New bone formation adjacent to the implant shows a close relationship to the surface Ce4+/Ce3+ ratio; higher Ce4+/Ce3+ ratio achieves better osseointegration. The mechanism of this in vivo outcome is explored by culturing rat BMSCs and RAW264.7 murine macrophages on CeONP samples for different durations. The improvement in osteogenic differentiation capability of BMSCs is directly proportional to the increased Ce4+/Ce3+ ratio on the titanium surface. Increases in the Ce4+/Ce3+ ratio also elevate the polarization of the M2 phenotype of RAW264.7 murine macrophages, particularly with respect to the healing‐associated M2 percentage and anti‐inflammatory cytokine secretion. The manipulation of valence states of CeONPs appears to provide an effective modulation of the osteogenic capability of stem cells and the M2 polarization of macrophages, resulting in favorable outcomes of new bone formation and osseointegration.

show abstract

“…The term "endotoxin" is mostly used synonymously with LPS, which is a potent inducer of inflammation. In combination with the biomaterial, it tends to escalate a fibrotic response or a foreign body reaction, thus leading to bio-incompatibility (Franz, Rammelt, Scharnweber & Simon, 2011). FDA has strict regulations on contamination levels allowed in medical application (USP, 2011a, b).…”

Section: Discussionmentioning

confidence: 99%

Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells

Nordli

Chinga-Carrasco²,

Rokstad

et al. 2016

Carbohydrate Polymers

103

125

View full text Add to dashboard Cite

 Cellulose nanofibril dispersion (50 µg/ml) did not affect the cytotoxicity or metabolic activity of Normal Human Dermal Fibroblasts and Human Epidermal Keratinocytes  Aerogels made of cellulose nanofibrils induced a reduction of metabolic activity by the fibroblasts and keratinocytes, but no significant cell death  Cytokine profiling measuring 27 cytokines revealed that the keratinocytes and fibroblasts did not induce cytokines upon direct exposure to the CNF materials. Due to the nano dimension of the CNFs, the aerogels had a high moisture-holding capacity (~7500%) 3 AbstractWood cellulose nanofibrils have been suggested as a potential wound healing material, but its utilization is limited by FDA requirements regarding endotoxin levels. In this study a method using sodium hydroxide followed by TEMPO mediated oxidation was developed to produce ultrapure cellulose nanofibrils (CNF), with an endotoxin level of 45 endotoxin units/g (EU/g) cellulose. Scanning transmission electron microscopy (S(T)EM) revealed a highly nanofibrillated structure (lateral width of 3.7±1.3 nm).Assessment of cytotoxicity and metabolic activity on Normal Human Dermal Fibroblasts and Human Epidermal Keratinocytes was done. CNF-dispersion of 50 g/ml did not affect the cells. CNF-aerogels induced a reduction of metabolic activity by the fibroblasts and keratinocytes, but no significant cell death. Cytokine profiling revealed no induction of the 27 cytokines tested upon exposure to CNF. The moisture-holding capacity of aerogels was relatively high (~7500%), compared to a commercially available wound dressing (~2500%),indicating that the CNF material is promising as dressing material for management of wounds with a moderate to high amount of exudate.

show abstract

Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials

Cited by 1,203 publications

References 249 publications

Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization

Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization

Valence State Manipulation of Cerium Oxide Nanoparticles on a Titanium Surface for Modulating Cell Fate and Bone Formation

Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells

Contact Info

Product

Resources

About