Immune responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito bites

Peng, Zhikang; Beckett, Andrew; Engler, Renata J.M.; Hoffman, Donald R.; Ott, Nancy L.; Simons, F. Estelle R.

doi:10.1016/j.jaci.2004.08.014

Cited by 117 publications

(95 citation statements)

References 24 publications

(43 reference statements)

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“…Nevertheless, bullous reactions after contacts with Cimex lectularius bites have been related to specific IgE Ab [26]. In addition, anti-saliva IgE has been implicated in allergic reactions to Aedes albopictus bites [27]. Local phenomena not represented in the peripheral blood may also explain such differences.…”

Section: Discussionmentioning

confidence: 99%

Human anti‐saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis

et al. 2007

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Experiments in animals verified that phlebotomine saliva enhances Leishmania infection, and vaccination with saliva prevents disease. We have shown that individuals from an endemic area of visceral leishmaniasis displayed robust antibody responses to saliva from the vector Lutzomyia longipalpis, which correlated with anti-parasite cellmediated immunity. Here, we explored human anti-saliva responses following exposure to sand flies, using an in vivo bite model in which normal volunteers were exposed four times to 30 laboratory-reared Lu. longipalpis. Following the third exposure, normal volunteers developed diverse dermatological reactions at the site of insect bite. Serum from normal volunteers displayed high levels of anti-salivary gland sonicate IgG1, IgG4 and IgE as well as several salivary gland proteins. Furthermore, following in vitro stimulation with salivary gland sonicate, there was an increased frequency of CD4 + CD25 + and CD8 + CD25 + T cells as well as IFN-c and IL-10 synthesis. Strikingly, 1 year after the first exposure, PBMC from the volunteers displayed recall IFN-c responses that correlated with a significant reduction in infection rates using a macrophage-lymphocyte autologous culture. Together, these data suggest that human immunization against sand fly saliva is feasible and recall responses are obtained even 1 year after exposure, opening perspectives for vaccination in man.

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Section: Discussionmentioning

confidence: 99%

Human anti‐saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis

et al. 2007

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“…The allergic reaction usually develops to allergens in the saliva 11 .There are five stages of the reaction 12 . Initially there is a phase in which there is no reaction (Stage 1).…”

Section: Mechanism Of Papular Urticariamentioning

confidence: 99%

Papular Urticaria: A Known Early Indicator of Atopic Dermatitis

Thomas¹,

Ravi²

2017

ARC Journal of Dermatology

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“…La hematofagia ha evolucionado de manera independiente varias veces en los insectos, lo cual implica que también ha habido variaciones importantes en el secretoma de la saliva como adaptación al proceso de coespeciación con su huésped (7). Sin embargo, a pesar de estas particularidades, también hay moléculas comunes en los insectos con un importante grado de conservación, las cuales causan reacción cruzada.…”

Section: Reacción Cruzadaunclassified

Papular urticaria: A review of causal agents in Colombia

et al. 2016

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López: análisis bioinformático y datos experimentales inéditos Todos los autores contribuyeron en igual medida a la redacción del manuscrito. La urticaria papular es una enfermedad alérgica causada por la picadura de insectos, la cual predomina en el trópico. El objetivo de esta revisión fue profundizar en sus aspectos epidemiológicos e inmunológicos, particularmente con base en datos publicados en Latinoamérica. Se hizo una revisión no sistemática mediante la búsqueda electrónica de artículos sobre la epidemiología de la urticaria papular, las características entomológicas de los agentes causales y los mecanismos inmunológicos asociados. Según los diversos reportes de centros médicos de Latinoamérica la urticaria papular es frecuente; el único estudio de prevalencia publicado indica que afecta a una cuarta parte de los niños escolares de Bogotá. Hay información sobre la relación causal entre la exposición domiciliaria a la pulga, la pobreza y la urticaria papular en Bogotá, una ciudad representativa de las altitudes andinas. No hay estudios que indaguen directamente sobre los insectos causales en zonas cálidas, aunque se sospecha clínicamente de los mosquitos Aedes aegypti y Culex quinquefasciatus. En cuanto a su patogenia, se destaca la participación de mecanismos celulares que involucran las células colaboradoras Th2, lo cual explica que sea una condición de hipersensibilidad retardada. El papel de la inmunoglobulina E (IgE) en la urticaria papular no está tan claro. Se desconocen los antígenos derivados de los insectos que causan la enfermedad, aunque se plantea que existen moléculas comunes de reacción cruzada entre los insectos, tales como el alérgeno Cte f 2 en la pulga, y sus homólogos en los mosquitos. La urticaria papular es una condición frecuente en Latinoamérica que debe investigarse en profundidad. La caracterización inmunológica de los componentes moleculares que causan esta condición puede resolver interrogantes sobre su etiología y su patogenia. Urticaria papular y sus agentes causales en ColombiaPalabras clave: urticaria; insectos; Aedes; Culex; Ctenocephalides; hipersensibilidad. doi: http://dx.doi.org/10.7705/biomedica.v36i4.3258 Papular urticaria: A review of causal agents in ColombiaPapular urticaria is a chronic allergic reaction induced by insect bites, which is common in the tropics. The objective of this review was to deepen on epidemiological and immunological aspects of this disease, focused on data published in Latin American countries. We conducted a non-systematic review of the literature through electronic search on the epidemiology of papular urticaria, the entomological characteristics of the causative agents and associated immunological mechanisms. Several reports from medical centers suggest that papular urticaria is common in Latin America. Only one epidemiological survey designed to estimate prevalence of papular urticaria has been published, reporting that about a quarter of children under six years of age is affected by this condition in Bogotá. There is evidence on the ca...

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Immune responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito bites

Cited by 117 publications

References 24 publications

Human anti‐saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis

Human anti‐saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis

Papular Urticaria: A Known Early Indicator of Atopic Dermatitis

Papular urticaria: A review of causal agents in Colombia

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