Immune Responsiveness in the Neonatal Period

Morein, Brør; Blomqvist, Gunilla; Hu, Kefei

doi:10.1016/j.jcpa.2007.04.008

Cited by 80 publications

(67 citation statements)

References 13 publications

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“…However, to our knowledge, the effect of sow vaccination on fetal PCV2 replication in utero has not been investigated to date. Detectable differences in the immune response following vaccination of pregnant animals and differences in immune regulation in the uterus during pregnancy have been reported (22,40). In the current study, sows were vaccinated after confirmation of pregnancy due to the limited availability of PCV2-naïve sows.…”

Section: Discussionmentioning

confidence: 98%

Effect of Porcine Circovirus Type 2 (PCV2) Vaccination of the Dam on PCV2 Replication In Utero

Madson

Patterson

Ramamoorthy

et al. 2009

Clin Vaccine Immunol

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The aims of this study were to determine if porcine circovirus type 2 (PCV2) vaccination of the dam is effective in preventing fetal PCV2 infection and reproductive failure. Twelve pregnant, PCV2-naïve sows were randomly divided into four groups, with three sows in each group. Group 1 sows served as noninoculated, nonvaccinated negative controls, group 2 sows were vaccinated with a commercially available PCV2 vaccine at 28 days of gestation and were not inoculated, group 3 sows were vaccinated at 28 days of gestation and inoculated with PCV2b at 56 days of gestation, and group 4 sows were inoculated with PCV2b but were not vaccinated. Serum samples from all sows were collected weekly throughout the gestation period, and sows were allowed to farrow naturally. At parturition, sow colostrum samples, presuckle serum samples, and tissues from the piglets were collected. Reproductive failure was not observed under the study conditions. PCV2 vaccination induced PCV2-specific immunoglobulin G and serum neutralizing antibodies in sows from groups 2 and 3 and prevented detectable PCV2 viremia in the dams after challenge. In group 3, PCV2 DNA was detected in colostrum samples, fetuses, and live-born pigs; however, microscopic lesions and PCV2-specific antigen were not present in any of the fetuses in this group. The results from this study indicate that vertical transmission of PCV2 can occur in PCV2-vaccinated dams.

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Section: Discussionmentioning

confidence: 98%

Effect of Porcine Circovirus Type 2 (PCV2) Vaccination of the Dam on PCV2 Replication In Utero

Madson

Patterson

Ramamoorthy

et al. 2009

Clin Vaccine Immunol

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“…Therefore, vaccination is one of the most practical measures for protecting calves. Since the presence of maternally-derived antibodies is known to reduce the effectiveness of vaccines [18], it is important to consider the timing of maternal antibody decay when young calves are vaccinated [3]. Although vaccination is ideally carried out in consideration of a previously measured antibody titer, testing all calves on farms is unrealistic due to the cost and time required.…”

mentioning

confidence: 99%

Duration of Maternally Derived Antibodies against Akabane Virus in Calves: Survival Analysis

et al. 2009

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ABSTRACT. To prevent encephalomyelitis caused by Akabane virus, as observed in 2006, vaccination of calves is one of the most effective prophylactic measures. For vaccination of calves, the duration of the maternal antibodies need to be considered because these antibodies are an obstacle to the effectiveness of the vaccine. In order to estimate the age of antibody decay in calves and to find factors influencing the duration of passive immunity, we conducted survival analysis using data from nationwide sentinel surveillance for Akabane disease. The accelerated failure time model based on the presence of interval censored data was used. The best fit model with a log-logistic distribution indicated that the maternal antibodies of beef calves last 1.11 times longer (95% confidence interval [CI]=1.06-1.16) than those of dairy calves. Calves in the western part of Japan and on Kyushu island, Japan, maintained the maternal antibodies 1.17 times (95% CI=1.11-1.23 and 1.10-1.24, respectively) longer than those in the eastern part of Japan. The ages at which beef calves in the eastern part of Japan, western part of Japan and Kyushu loose the antibodies, with 90% probability, were estimated to be 4.1, 4.8 and 4.8 months, respectively, while the ages were 3.7, 4.3 and 4.3 months for dairy calves in the same regions. The duration of maternal immunity to Akabane virus was different for different types of cattle and among different regions. These differences need to be taken into account when a vaccination strategy is adopted for preventing epizootic encephalomyelitis in the future.KEY WORDS: AFT model, akabane virus, maternal antibody, survival analysis.

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“…Sin embargo, dicha proporción puede considerarse elevada con respecto al 19,2% reportado por Beam et al (2009) en fincas lecheras en los Estados Unidos. En ese mismo país, también se ha reportado que alrededor de un 35% de las terneras sufren de FTIP, convirtiéndose en un factor económico importante para los productores de leche (Morein et al, 2007), ya que tienen que invertir importantes cantidades de dinero en el tratamiento de enfermedades causadas por agentes patógenos. Asimismo en otro estudio se reportó una mortalidad en terneras en la etapa de pre-destete promedio de 7,9% y una gran proporción de estas muertes se le atribuyen a una FTIP (NAHMS, 2007).…”

Section: Resultados Y Discusiónunclassified

Caracterización de la transferencia de inmunidad pasiva en terneras de lechería.

Elizondo-Salazar

2015

Agron. Mesoam.

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RESUMENCaracterización de la transferencia de inmunidad pasiva en terneras de lechería. El objetivo del presente trabajo fue determinar la transferencia de inmunidad pasiva en terneras de lechería en Costa Rica. Los datos presentados corresponden a medidas de proteína sérica total (PST) obtenidas en el periodo comprendido entre los años 2010 y 2013, durante los meses de agosto a noviembre en 50 fincas lecheras. Se evaluaron 2500 terneras nacidas de vacas Holstein, Jersey, cruce Holstein×Jersey y otras. Para fines del presente estudio, se consideró una falla en la transferencia de inmunidad pasiva (FTIP) cuando la concentración de PST fue menor a 5,5 g/dl. La concentración de PST varió entre 2,0 y 10,0 g/dl, con un promedio de 5,9 g/ dl. De todos los animales muestreados un 38,8% presentaron FTIP. Los animales provenientes de la raza Jersey y del cruce Holstein×Jersey obtuvieron una concentración de PST significativamente mayor (P<0,05) a los de las razas Holstein y otras. Al considerar el número de parto de la madre, no se encontraron diferencias significativas en la concentración de PST de las crías. Las crías de vacas de primer parto presentaron la menor proporción de animales con FTIP. La concentración de PST varió significativamente (P<0,05) entre las terneras que permanecieron con la madre y las que fueron alimentadas con biberón, y la proporción de animales con FTIP fue mayor cuando estos permanecieron con la madre (44 vs. 33%).Palabras clave: proteína sérica total, calostro, inmunoglobulinas, ganado de leche.

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Immune Responsiveness in the Neonatal Period

Cited by 80 publications

References 13 publications

Effect of Porcine Circovirus Type 2 (PCV2) Vaccination of the Dam on PCV2 Replication In Utero

Effect of Porcine Circovirus Type 2 (PCV2) Vaccination of the Dam on PCV2 Replication In Utero

Duration of Maternally Derived Antibodies against Akabane Virus in Calves: Survival Analysis

Caracterización de la transferencia de inmunidad pasiva en terneras de lechería.

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