1981
DOI: 10.1084/jem.154.3.726
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Immune responsiveness of SM/J mice. Cellular characteristics and genetic analysis of hyperresponsiveness to B cell mitogens.

Abstract: We tested the proliferative responses of splenocytes from a panel of inbred mouse strains to AVIS, a B cell mitogen from Actinomyces viscosus bacteria. The SM/J strain was found to exhibit severalfold higher responsiveness than any of the other strains. SM/J splenocytes were also hyperresponsive to the B cell mitogens lipopolysaccharide, dextran sulfate, and purified protein derivative of tuberculin, but responsiveness to the T cell mitogen phytohemagglutinin was normal. (B6 X SM)F1 and F1 x B6 backcross mice … Show more

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Cited by 10 publications
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“…The SM/J mouse, for example, is exceptional in reduced post‐weanling growth rate 19. In addition, the SM/J mouse is deficient in the enzyme neuraminidase 1 20 and exhibits altered T‐cell and B‐cell responsiveness 21. The latter may reflect the altered transcripts identified in the B‐cell receptor signaling pathway (Supporting Information Fig.…”
Section: Discussionmentioning
confidence: 99%
“…The SM/J mouse, for example, is exceptional in reduced post‐weanling growth rate 19. In addition, the SM/J mouse is deficient in the enzyme neuraminidase 1 20 and exhibits altered T‐cell and B‐cell responsiveness 21. The latter may reflect the altered transcripts identified in the B‐cell receptor signaling pathway (Supporting Information Fig.…”
Section: Discussionmentioning
confidence: 99%